Search results for "Issues"
showing 10 items of 669 documents
Perfiles de familias con factores de riesgo y problemas comportamentales en niños con déficit de atención con hiperactividad
2019
Introducción. La literatura evidencia que las familias de niños con déficit de atención e hiperactividad (TDAH) experimentan factores de riesgo relacionados con niveles elevados de estrés, menor apoyo social, o menor capacidad de afrontamiento. Estos factores familiares contextuales pueden verse agravados por la presencia de problemas comportamentales y sociales en niños con TDAH. Objetivos. El presente estudio se planteó los siguientes objetivos: 1) Identificar perfiles de familias de niños con TDAH en edad escolar de acuerdo con indicadores contextuales y variables socioemocionales como el nivel de estrés, las estrategias de afrontamiento y el apoyo social. 2) Evaluar las diferencias entr…
Dystrophin and metalloproteinase 9 in myocardial ischemia: A post-mortem immunohistochemical study
2021
The presented study evaluated the expression of dystrophin and MMP-9 in cases of sudden cardiac death (SCD) due to coronary atherosclerotic disease (CAD) in order to analyze the characteristics and the chronology of their expression, providing evidence on the possible role in post-mortem diagnosis of myocardial ischemia. The expression of these proteins was also compared to C5b-9 complex and fibronectin expression to evaluate any differences. Two groups of CAD-related SCD, respectively group 1 with gross and/or histological evidence and group 2 with no specific histological signs of myocardial ischemia, were used. A third group formed by cases of acute mechanical asphyxiation was used as a …
Models of Biobanking and Tissue Preservation: RNA Quality in Archival Samples in Pathology Laboratories and “In Vivo Biobanking” by Tumor Xenografts …
2011
Tissue banks represent essential resources and platforms for biomedical research serving basic, translational, and clinical research projects. In this article, we describe 2 models of biobanking and tissue preservation with different approaches and aims. Archive tissue biobanking is described here as a resource of residual pathology tissues for translational research, which represents the huge clinical heterogeneity. In this context, managing of tissues and RNA quality in archive tissue are discussed. The other model of tissue biobanking is referred to as xenograft tissue banking, which represents an alternative method for obtaining large amounts of tissue, over an indefinite period, in so …
Cardiac tissue engineering: a reflection after a decade of hurry
2014
The heart is a perfect machine whose mass is mainly composed of cardiomyocytes, but also fibroblasts, endothelial, smooth muscle, nervous, and immune cells are represented. One thousand million cardiomyocytes are estimated to be lost after myocardial infarction, their loss being responsible for the impairment in heart contractile function (Laflamme and Murry, 2005). The potential success of cardiac cell therapy relies almost completely on the ability of the implanted cells to differentiate toward mature cardiomyocytes. These cells must be able to reinforce the pumping activity of the injured heart in the absence of life-threatening arrhythmias due to electrophysiological incompatibility. Th…
Key challenges for Latvian teachers in mainstream schools: a basis for preparing teachers for inclusion
2010
This paper analyses current research in Latvia to identify key issues related to inclusive education, special education and social pedagogy. A review of Latvian literature since 2004 was undertaken to determine what is known about special and inclusive education, how it is reflected in various research papers and how it related to the current situation in schools. Key findings suggest that teachers need to be better informed about the potential of inclusion. They need to be prepared to teach children with diverse educational needs in a changing educational landscape. Teacher education for inclusion is identified as a 21st-century priority in Latvia.
In vitro and in vivo investigations of osteogenic differentiation ability of dental pulp stem cells (DPSCs) and gingival mesenchymal stem cells (GMSC…
2020
Thanks to the use of human mesenchymal stem cells (hMSCs), smart biomaterials and active biomolecules, Regenerative Medicine (RM) and Bone Tissue Engineering (BTE) can restore structure and function of injured tissues. Among the different sources of hMSCs, the oro-facial hMSCs have promising in vitro and in vivo regeneration potential; in particular, dental pulp and gingiva are valuable sources of autologous hMSCs. The aim of this PhD thesis is testing the in vitro and in vivo bone regeneration ability of hMSCs isolated from dental pulp and inflamed gingiva of periodontally-compromised teeth, up to now considered biological waste tissues and discarded during surgical procedures, on two comm…
Why should We Bother? Ethical and Social Issues in Individualized Medicine
2006
Individualized medicine, methodologically rooted in pharmacogenetics and pharmacogenomics, is now venturing into clinical application. Prescribing the right drug in the right dose to the right patient according to specific health needs and individual characteristics is a core mission of individualized medicine. The intrinsic values of this mission are so self-evident that--at first glance--the ethical and social issues raised by individualized medicine seem to be negligible. However, the translation of pharmacogenetics and pharmacogenomics into clinical routine not only requires the collection and evaluation of large amounts of individual genetic data, but also heralds the need for further …
Gene therapy and editing in the treatment of hereditary blood disorders: Medical and ethical aspects
2021
Gene therapy and gene editing are revolutionising the treatment of genetic diseases, most notably haematological disorders. This paper evaluates the use of both techniques in hereditary blood disorders. Many studies have been conducted in this field, especially with gene therapy, with very promising results in diseases such as haemophilia, certain haemoglobinopathies and Fanconi anaemia. The application of these techniques in clinical practice and the foreseeable development of these approaches in the coming years suggest that it might be useful to evaluate the results achieved thus far. It is also essential to reflect on the possible bioethical concerns raised by the use of both technique…
Gestational surrogacy. Ethical aspects / Maternità surrogata. Questioni etiche
2018
Gestational surrogacy is the practice that takes place when a woman becomes pregnant with a foetus with which she is not genetically related, and the eggs used to produce it come from a donor or the contracting mother, to whom the baby will be handed over after the birth. The woman acting as surrogate may be contracted commercially and remunerated for her service, or the surrogacy may be altruistic, a circumstance that arises when, generally, a member of the family or friend selflessly volunteers. The ethical debate lies in which should prevail: the hypothetical right of the parents to have a child, the reproductive rights of the woman, or even the good of the child itself. At the heart of …
Maternal-foetal immunity: an admirable design in favour of life
2014
La modulazione della risposta immunitaria materno-fetale, volta a beneficiare la gestazione di un individuo il cui materiale genetico e estraneo a quello della madre (poiche il 50% e di origine paterna), e un processo biologico, unico, molto complesso, che coinvolge il padre, la madre e il bambino. I primi segnali emessi dal liquido seminale sono gia in grado di promuovere l’inizio di un adattamento immunitario, in cui gli antigeni espressi successivamente dal feto e la sequenza di meccanismi umorali e cellulari dei quali la madre sara responsabile nell’ultimo trimestre, formeranno un ambiente di equilibrio omeostatico, in cui i processi di tolleranza immunitaria volti a tutelare la nuova v…