Search results for "Italy"

showing 10 items of 2893 documents

Cardiac Injury in COVID-19–Echoing Prognostication∗

2020

Background Myocardial injury is frequent among patients hospitalized with coronavirus disease-2019 (COVID-19) and is associated with a poor prognosis. However, the mechanisms of myocardial injury remain unclear and prior studies have not reported cardiovascular imaging data. Objectives This study sought to characterize the echocardiographic abnormalities associated with myocardial injury and their prognostic impact in patients with COVID-19. Methods We conducted an international, multicenter cohort study including 7 hospitals in New York City and Milan of hospitalized patients with laboratory-confirmed COVID-19 who had undergone transthoracic echocardiographic (TTE) and electrocardiographic…

Malemyocaardial injuryCoronary AngiographyElectrocardiographyPandemicVentricular Dysfunctionechocardiographymyocardial injuryOriginal Investigationechocardiography; inflammation; myocaardial injury; SARS-CoV-2; troponin; COVID-19COVID-19 coronavirus disease-2019biologyViral EpidemiologytroponinHeartMiddle AgedRV right ventriclemyocardial infarctionItalyTTE transthoracic echocardiographyFemaleCardiology and Cardiovascular MedicineCoronavirus InfectionsEditorial Comment2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pneumonia ViralAKI acute kidney injuryECG electrocardiographyBetacoronavirusmedicineHumansPandemicsARDS acute respiratory distress syndromeIQR interquartile rangeAgedRetrospective Studiesbusiness.industrySARS-CoV-2MyocardiumCOVID-19medicine.diseasebiology.organism_classificationVirologyCOVID-19 Drug TreatmentCI confidence intervalOR odds ratioPneumoniaLV left ventricleinflammationACS acute coronary syndromeNew York CitybusinessCoronavirus InfectionsBetacoronavirusBiomarkersJournal of the American College of Cardiology
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Role of abdominal obesity for functional outcomes and complications in men treated with radical prostatectomy for prostate cancer: results of the Mul…

2014

Objective. This study aimed to evaluate the impact of abdominal obesity on preoperative features, complications and functional outcomes of men treated with radical prostatectomy (RP) for prostate cancer. Material and methods. In 2006 a multicentre Italian report on RP evaluated the surgical and functional characteristics of prostate cancer and RP outcomes. Age and waist circumference (WC) were recorded. Abdominal obesity was defined as a WC of at least 102 cm. International Index of Erectile Function (IIEF) score, prostate-specific antigen, prostate volume, tumour characteristics, presence/absence of perioperative complications and the number of blood units transfused were recorded. Preoper…

Maleobesitymedicine.medical_treatmentLogistic regressionsurgeryProstate cancerPostoperative ComplicationsErectile DysfunctionProstateProspective StudiesProspective cohort studyAbdominal obesityProstatectomyMiddle Agedprostate cancerTreatment Outcomemedicine.anatomical_structureItalyNephrologyObesity AbdominalabdominalepidemiologyWaist Circumferencemedicine.symptomHumanmedicine.medical_specialtyWaistcomplicationsUrologyUrologymethodsabdominal obesityincontinenceepidemiology/etiologymedicineHumansAgedProstatectomybusiness.industryfunctional outcomes and complicationProstatic Neoplasmsmethods; abdominal; prospective studies; erectile dysfunction; male; obesity; epidemiology; middle aged; treatment outcome; humans; prostatic neoplasms; epidemiology/etiology; surgery; aged; incontinence; complications; waist circumference; prostatectomy; postoperative complications; prostate cancer; urinary incontinence; italyPerioperativemedicine.diseaseradical prostatectomyMIRRORProspective StudieUrinary IncontinenceProstatic NeoplasmPostoperative ComplicationbusinessComplicationScandinavian Journal of Urology
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Injectable Versus Oral First-Line Disease-Modifying Therapies: Results from the Italian MS Register

2021

AbstractThe current study aims to compare injectable and oral first-line disease-modifying therapies (DMTs) for time to first relapse, time to confirmed disability progression (CDP), and time to discontinuation using a cohort of relapsing remitting multiple sclerosis (RRMS) patients, with data extracted from the Italian MS Register. This multicenter, observational, retrospectively acquired, and propensity-adjusted cohort study utilized RRMS-naïve patients from the Italian MS Register who started either injectable or oral first-line DMTs between January 1, 2010, and December 31, 2017, to evaluate the impact on disability outcomes in patients. Enrolled patients were divided into two groups, n…

Maleoral DMTsoral DMTAdministration OralDiseaseRelapsing-RemittingCohort Studies0302 clinical medicineImmunologicinjectable DMTPharmacology (medical)030212 general & internal medicineRegistriesSubcutaneousMiddle AgedItalyEDSS score; injectable DMTs; Multiple sclerosis; oral DMTs; real-world setting; Adjuvants Immunologic; Administration Oral; Adult; Cohort Studies; Female; Follow-Up Studies; Glatiramer Acetate; Humans; Immunologic Factors; Injections Subcutaneous; Interferon-beta; Italy; Male; Middle Aged; Multiple Sclerosis Relapsing-Remitting; Retrospective Studies; RegistriesAdministrationCohortSettore MED/26 - NeurologiaOriginal ArticleFemaleNeurosurgeryCohort studyOralAdultmedicine.medical_specialtyEDSS scoreInjections SubcutaneousLower riskInjectionsMultiple sclerosis03 medical and health sciencesMultiple Sclerosis Relapsing-RemittingAdjuvants ImmunologicInternal medicinereal-world settingmedicineHumansImmunologic FactorsMultiple sclerosiAdjuvantsinjectable DMTsRetrospective StudiesPharmacologybusiness.industryMultiple sclerosisGlatiramer AcetateInterferon-betamedicine.diseaseDiscontinuationObservational studyNeurology (clinical)business030217 neurology & neurosurgeryFollow-Up Studies
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Costs and Benefits of Orthographic Inconsistency in Reading: Evidence from a Cross-Linguistic Comparison.

2016

We compared reading acquisition in English and Italian children up to late primary school analyzing RTs and errors as a function of various psycholinguistic variables and changes due to experience. Our results show that reading becomes progressively more reliant on larger processing units with age, but that this is modulated by consistency of the language. In English, an inconsistent orthography, reliance on larger units occurs earlier on and it is demonstrated by faster RTs, a stronger effect of lexical variables and lack of length effect (by fifth grade). However, not all English children are able to master this mode of processing yielding larger inter-individual variability. In Italian, …

Maleorthographic consistencyCost-Benefit AnalysisSocial Scienceslcsh:MedicineAcademic SkillsPsycholinguisticsLiteracyFamilies0302 clinical medicineSociologyReading (process)PsychologyEthnicitiesChildlcsh:ScienceChildrenreading; cross-linguistic; orthographymedia_commonLanguageorthographyMultidisciplinaryPsycholinguisticsSchoolsCost–benefit analysis05 social sciencesOrthographic projectionSyllablescross-linguisticItalian PeopleLanguage developmentEnglandItalyFemalePsychologyCognitive psychologyCross linguisticResearch Articlemedia_common.quotation_subjectPhonologyLanguage Development050105 experimental psychologyEducation03 medical and health sciencesLiteracyReading acquisitionHumans0501 psychology and cognitive scienceslcsh:RCognitive PsychologyBiology and Life SciencesPhonemesReproducibility of ResultsLinguisticsReadingAge Groupscross-linguistic comparisonPeople and PlacesCognitive SciencePopulation Groupingslcsh:Q030217 neurology & neurosurgeryOrthographyNeurosciencePLoS ONE
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Teratoma with a malignant somatic component in pediatric patients: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience

2010

BACKGROUND: Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse. PROCEDURE: The Associazione Italiana Ematologia Oncologia Pediatrica identified 14 cases of TMSC. Clinical files and pathology specimens were reviewed. RESULTS: The series (9 female, 5 male) showed the following disease: testis (2), sacrococcygeal (3), ovary (3), retroperitoneum (3), mediastinum (2), and foot soft tissue (1). Distribution of the somatic component was: carcinoma (4), pancreatic neuroendocrine tumor (1), neuroblastoma (3), rhabdomyosarcoma (3), rhabdomyosarcoma plus liposarcoma, chondrosarcoma, neurogenic sarcoma (1), chondro…

Malepediatric patientsAdolescentTeratoma; pediatric patientsSettore MED/20 - Chirurgia Pediatrica E InfantileInfant NewbornTeratomaInfantgerm cell tumorPrognosisSettore MED/38 - Pediatria Generale E SpecialisticaTreatment OutcomeItalyChild PreschoolSettore MED/20Humansmalignant trasformationFemaleChildchildhoodNeoplasm StagingRetrospective Studies
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Workplace violence among healthcare workers, a multicenter study in Italy

2022

Objectives: The purpose of this study is to assess the prevalence and determinants of workplace violence and the sociodemographic risk factors associated. Study design: This was a multicenter cross-sectional study. Methods: The study was performed using self-compiled Italian version of the World Health Organization's questionnaire on workplace violence online by filling in a Google form. The survey was opened from May 2018 to March 2020 and lasted 5-10 min. Results: The sample consists of 3659 healthcare workers, of which 2525 (69%) are females, 1446 (39.5%) are nurses, and 2029 (55.5%) are health workers from northern Italy. The most frequent age group of the sample is 50-54 years (16.7%).…

Malephysical aggressionHealth PersonnelprevalencePublic Health Environmental and Occupational HealthPhysical aggression Prevalence Risk factor Verbal abuse Workplace violenceGeneral MedicineMiddle AgedAggressionverbal abuseCross-Sectional StudiesItalyrisk factorSurveys and Questionnairesworkplace violenceHumansFemalephysical aggression; prevalence; risk factor; verbal abuse; workplace violenceWorkplace
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The prevalence of musculoskeletal disorders and low back pain among Italian nurses. An observationalstudy

2020

Background and aim of the work: Musculoskeletal disorders and low back pain have negative impact amongst Italian nurses who work in hospital. Nursing staff are known to be at risk of developing back disorders, where low back pain has a prevalence from 16% to 60% in the world. This study aims to determine the prevalence of musculoskeletal disorders and low back pain among nurses who working in a Roman hospital. Methods: Cross sectional study was carried out in an Italian hospital and the Nordic Musculoskeletal Questionnaire-IRSST was administered to 256 registered nurses. Logistic regression analyses were performed to understand risk factors associated with pain. Results: Nurses reported dif…

MaleprevalencenurseNursesOriginal Article: Healthcare Professionals: Physical and Psychological ConditionsSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatricheOccupational DiseasesCross-Sectional StudiesnursingSurveys and QuestionnairesitalyHumansrisk factorsFemaleitaly; low back pain; musculoskeletal disorder; nurse; prevalence; risk factorsmusculoskeletal disorderMusculoskeletal Diseaseslow back pain
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Efficacy of switching between tumor necrosis factor-alfa inhibitors in psoriasis: results from the Italian Psocare registry

2014

Background: Some studies have shown that switching patients from one tumor necrosis factor (TNF)-alfa inhibitor to another may be beneficial when they have an inadequate response or an adverse event. Objective: We sought to assess the variables predicting the efficacy of the second TNF-alfa inhibitor in patients discontinuing the first TNF-alfa inhibitor. Methods: Data from all 5423 consecutive patients starting TNF-alfa inhibitor therapy for psoriasis between September 2005 and September 2010 who were included in the Italian Psocare registry were analyzed. Results: In 105 patients who switched to a second TNF-alfa inhibitor who had complete follow-up data, 75% improvement in the Psoriasis …

Maleprimary inefficacy75% improvement in the Psoriasis Area Severity Index score; PASI; PASI 75; Psoriasis Area Severity Index; TNF; biologics; efficacy; primary inefficacy; psoriasis; secondary loss of efficacy; switching; tumor necrosis factor; tumor necrosis factor-alfa inhibitors; Adult; Analysis of Variance; Antibodies Monoclonal; Antibodies Monoclonal Humanized; Cohort Studies; Confidence Intervals; Dose-Response Relationship Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Immunoglobulin G; Italy; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Proportional Hazards Models; Psoriasis; Receptors Tumor Necrosis Factor; Registries; Retrospective Studies; Risk Assessment; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Young AdultSWITHCESefficacyTNFpsoriasis; psoriasis arthritis; pharmachological treatmentPASI 75Severity of Illness IndexReceptors Tumor Necrosis FactorEtanerceptCohort StudiesMonoclonalReceptorsSettore MED/35 - Malattie Cutanee E VenereeRegistriesHumanizedtumor necrosis factor-alfa inhibitors.switchingHazard ratioAntibodies MonoclonalMiddle AgedTreatment OutcomeItalyPredictive value of tests75% improvement in the Psoriasis Area Severity Index scoreFemaleDrugPsoriasis Area Severity IndexbiologicTNF-alphaAdultmedicine.medical_specialtytumor necrosis factorDermatology75% improvement in the Psoriasis Area Severity Index score; PASI; PASI 75; Psoriasis Area Severity Index; TNF; biologics; efficacy; primary inefficacy; psoriasis; secondary loss of efficacy; switching; tumor necrosis factor; tumor necrosis factor-alfa inhibitorsAntibodies Monoclonal Humanizedsecondary loss of efficacyRisk AssessmentAntibodiestumor necrosis factor-alfa inhibitorsDrug Administration ScheduleDose-Response RelationshipYoung AdultSettore MED/35Predictive Value of TestsInternal medicinePsoriasisSeverity of illnessmedicineConfidence IntervalsHumansPsoriasisbiologicsAdverse effectPsoriasis; TNF-alphaProportional Hazards ModelsRetrospective Studiespsoriasibiologics; efficacy; primary inefficacy; psoriasis; secondary loss of efficacy; switching; tumor necrosis factor-alfa inhibitors; Adalimumab; Adult; Analysis of Variance; Antibodies Monoclonal; Antibodies Monoclonal Humanized; Cohort Studies; Confidence Intervals; Dose-Response Relationship Drug; Drug Administration Schedule; Etanercept; Female; Follow-Up Studies; Humans; Immunoglobulin G; Infliximab; Italy; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Proportional Hazards Models; Psoriasis; Receptors Tumor Necrosis Factor; Registries; Retrospective Studies; Risk Assessment; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult; 2708Analysis of Variancepharmachological treatmentDose-Response Relationship DrugProportional hazards modelbusiness.industrytumor necrosis factor-alfa inhibitorTumor Necrosis Factor-alphaPASIAdalimumabRetrospective cohort studypsoriasis arthritismedicine.diseaseConfidence intervalInfliximabSurgeryImmunoglobulin GMultivariate AnalysisANTI-TNFAbusiness2708Follow-Up Studies
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Acute rheumatic fever prophylaxis in high-income countries: clinical observations from an Italian multicentre, retrospective study.

2019

Objective-The aim of the study is to evaluate the compliance rate to secondary prophylaxis and the presence of Rheumatic Heart Disease (RHD) in a cohort of Italian patients with Acute Rheumatic Fever (ARF). Methods-This is a multicentre retrospective study. Patients were divided into two groups according to the presence or absence at last follow-up of RHD. Clinical features, ARF recurrences and the rate of compliance to secondary prophylaxis were evaluated. Results-wo hundred and ninety patients were enrolled (137 females, 153 males). Carditis at onset was present in 244 patients (84.7%). At the end of follow-up, 173 patients showed RHD. Adherence to secondary prophylaxis was low in 26% of …

MaleprophylaxiDeveloped CountriesRheumatic Heart Diseaseacute rheumatic fever; prophylaxis; rheumatic heart diseaseCarditirheumatic heart diseaseAcute rheumatic feveracute rheumatic feverSettore MED/38 - Pediatria Generale E SpecialisticaItalyHumansFemaleprophylaxisProphylaxiRheumatic FeverAcute rheumatic fever Carditis Compliance Prophylaxis Rheumatic heart diseaseComplianceRetrospective StudiesClinical and experimental rheumatology
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Prognostic factors in a large multi-institutional series of papillary renal cell carcinoma.

2011

OBJECTIVES To investigate cancer-related outcomes and prognostic factors of papillary renal cell carcinoma (pRCC) in a large multicentre data set. Oncological outcome and prognostic factors of pRCC have been limitedly evaluated in comparison with the most common RCC subtype, clear cell RCC. PATIENTS AND METHODS From a multicentre retrospective database, including 5463 patients who were surgically treated for RCC at 16 Italian academic centres between 1995 and 2007, 577 patients with pRCC were identified. Univariable and multivariable Cox regression models were performed to identify prognostic factors predictive of recurrence-free survival (RFS) and cancer-specific survival (CSS) after surge…

Malerenal cell carcinomaTime FactorsPapillary renal cell carcinoma; Prognostic factorsPrognosiFEATURESkidney cancer; papillaryrenal cell carcinoma; papillary adenocarcinoma; prognostic factorspapillary renal cell carcinomaNephrectomyCLASSIFICATIONFollow-Up Studiecancer-specific survivalpapillaryRisk FactorsRetrospective StudieCause of DeathPrevalenceHumansrecurrence-free survivalprognostic factorCarcinoma Renal CellTYPE-1Proportional Hazards ModelsRetrospective StudiesNeoplasm StagingAcademic Medical Centerspapillary adenocarcinomaRisk Factorkidney cancerKidney Neoplasmprognostic factorsMiddle AgedPrognosisTUMORSKidney NeoplasmsHISTOLOGIC SUBTYPESPrognostic factors in a large multi-institutional series of papillary renal cell carcinoma.Survival RateAcademic Medical CenterItalySURVIVALProportional Hazards ModelFemaleprognostic factors; papillary renal cell carcinoma; recurrence-free survival; cancer-specific survivalFollow-Up StudiesHuman
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