Search results for "Italy"
showing 10 items of 2893 documents
Effectiveness of adalimumab for ulcerative colitis: A multicentre, retrospective study of clinical practice in Italy.
2022
Abstract Background Adalimumab is used to treat ulcerative colitis, but additional effectiveness and safety data are needed. Patients and methods This retrospective study considered adults with ulcerative colitis treated with adalimumab at 19 hospitals. Clinical data were collected from the start of treatment, after 2, 6 and 12 months, and at the last visit. Outcome measures of effectiveness were treatment duration, reasons for discontinuation and colectomy. Results We studied 381 patients treated with adalimumab for a median of 12.1 months. Disease activity at the start of treatment was moderate to severe in 262 cases (68.8%) and endoscopic activity was moderate to severe in 339 cases (89.…
Analysis of HLA-DRB1,DQA1,DQB1 haplotypes in Sardinian centenarians
2008
Some genetic determinants of longevity might reside in those polymorphisms for the immune system genes that regulate immune responses. Many longevity association studies focused their attention on HLA (the human MHC) polymorphisms, but discordant results have been obtained. Sardinians are a relatively isolate population and represent a suitable population for association studies. Some HLA-DR and DQ alleles form very stable haplotypes with a strong linkage disequilibrium. In a previous study on Sardinian centenarians we have suggested that HLA-DRB1 *15 allele might be marginally associated to longevity. HLA-DR,DQ haplotypes are in strong linkage disequilibrium and well conserved playing a ro…
Presence of Serum Antinuclear Antibodies Does Not Impact Long-Term Outcomes in Nonalcoholic Fatty Liver Disease
2020
Introduction We investigated the longitudinal impact of antinuclear antibody (ANA) on clinical outcomes and survival in nonalcoholic fatty liver disease (NAFLD). Methods ANA were found in 16.9% of 923 biopsy-proven NAFLD patients, but none of them had histologic autoimmune hepatitis (AIH) or developed AIH after a mean follow-up of 106±50 months. Results Although ANA-positive cases had a higher prevalence of nonalcoholic steatohepatitis at baseline, the occurrence of liver-related events, hepatocellula carcinoma, cardiovascular events, extrahepatic malignancy, and overall survival were similar to ANA-negative. Discussion Once AIH has been ruled out, the long-term outcomes and survival are un…
A real life comparison of the effectiveness of adalimumab and golimumab in moderate-to-severe ulcerative colitis, supported by propensity score analy…
2018
Abstract Background Adalimumab and golimumab are effective in the treatment of moderate to severe ulcerative colitis. Aims We reported the comparative effectiveness of adalimumab and golimumab in ulcerative colitis. Methods 118 patients treated with adalimumab and 79 treated with golimumab were included and evaluated at 8 weeks and at the end of follow up. Results Overall clinical benefit was 72.6% at 8 weeks and 58.9% at the end of follow up. Patients with longer disease duration and those treated with adalimumab had a better outcome. Clinical benefit was 78.8% in adalimumab patients and 63.3% in golimumab patients (p = 0.026) after 8 weeks; it was 66.9% in adalimumab patients and 46.8% in…
Intra-articular corticosteroids versus intra-articular corticosteroids plus methotrexate in oligoarticular juvenile idiopathic arthritis: a multicent…
2017
Summary Background Little evidence-based information is available to guide the treatment of oligoarticular juvenile idiopathic arthritis. We aimed to investigate whether oral methotrexate increases the efficacy of intra-articular corticosteroid therapy. Methods We did this prospective, open-label, randomised trial at ten hospitals in Italy. Using a concealed computer-generated list, children younger than 18 years with oligoarticular-onset disease were randomly assigned (1:1) to intra-articular corticosteroids alone or in combination with oral methotrexate (15 mg/m 2 ; maximum 20 mg). Corticosteroids used were triamcinolone hexacetonide (shoulder, elbow, wrist, knee, and tibiotalar joints) o…
The rise of music historiography in Italy in the second half of the 19th century: Between positivism and evolutionism
2009
Alla tradizione della storia pensata e scritta dai filosofi, i quali deducevano il reale dall’universale secondo logiche aprioristiche, reagirono con forza i musicologi italiani L. Torchi e O. Chilesotti nella seconda metà del diciannovesimo secolo. La soggezione spontanea ai dettami del positivismo e dell’evoluzionismo permise a questi studiosi di affrontare qualsiasi tipo di linguaggio musicale, di rifiutare l’estetica romantica del sentimento associato ai simboli sonori e di dedicarsi alla raccolta dei reperti avanzando confronti sagaci sul piano delle forme e dei generi. Scopo del loro metodo, influenzato dalla coeva scuola degli studi storici della letteratura italiana, era dimostrare …
National identity, national music and popular music in the Italian Music Press during the long 19th century
2011
Discusses the notions of national identity, national music and popular music as they emerged in Italian music periodicals during the years 1840–1890, in relation to the process of Italy’s political unification and the dissemination of foreign operas such as French grands opéras in the years 1840–1870 and Wagner’s Musikdramen from 1871 on. Essays and articles by relevant critics and musicians, such as Abramo Basevi and Francesco D’Arcais are discussed. Articles by lesser known journalists such as Pietro Cominazzi and Mattia Cipollone are also taken into account. The use of words like “national” and “popular” is analysed when referring to Italian opera, to its history and to the operas by for…
New species of Deinogalerix (Mammalia, Eulipotyphla) from the late Miocene of Scontrone (Abruzzo, central Italy)
2017
Deinogalerix is a typical component of the late Miocene insular fauna of Gargano (south-eastern Italy). Remains of this taxon had also been found over the last 20 years at the early Tortonian site of Scontrone (Abruzzo, central Italy), but they had never been described in detail. Two new species are introduced. One of them, D. samniticus sp. nov., is larger sized and better documented, and received a formal description. The other entity is clearly distinct from D. samniticus sp. nov., but it is merely represented by a single mandible. It is therefore presented here as a different, but undetermined species, Deinogalerix sp. Comparative analyses show that the new species have exclusive dental…
European Modernity and the Passionate South
2023
En el largo siglo XIX, los estereotipos dominantes mostraban a las personas del sur mediterráneo como particularmente apasionadas e ingobernables y, por tanto, incapaces de adaptarse a los deberes morales y políticos impuestos por la civilización y la modernidad europeas. Este libro estudia, por primera vez en perspectiva comparada, la dimensión de género de un proceso que legitimó jerarquías internas entre el Norte y el Sur del continente. También analiza cómo se respondió a este fenómeno desde España e Italia, señalando las similitudes y diferencias entre ambos países. Empleando como fuentes de estudio los relatos de viajes, sátiras, obras filosóficas, novelas, obras de teatro, la ópera y…
Etiological factors of chronic hepatitis in Italy: a 2014 national survey.
2017
Background The last Italian prevalence survey on chronic hepatitis (CH) conducted in 2001 showed that the hepatitis C virus (HCV) was the main agent associated with CH. Aim The aim of this study was to evaluate epidemiological changes in CH occurring after 13 years. Patients and methods Enrollment of 1392 CH consecutive patients referred to 16 Italian liver units in 2014 scattered all over the country (four in the North, four in the Center, four in the South, and four in the Islands) was performed. Results The mean age of the patients was 58.3 years, with a sex ratio (male/female) of 1.5. HCV infection (also with other etiologies) continues to be the most prevalent etiology (58.1%). However…