Search results for "Item"
showing 10 items of 363 documents
Nouvelle approche pour l'estimation du rythme respiratoire basée sur la photopléthysmographie sans contact
2021
Respiratory rhythm is important information in medical context.Its assessment allows to predict some medical complications that could lead to death.However, it is often neglected by the medical staff due to a bad comprehension of its importance, or a lack of time.Automated measurement methods allow to improve this by continuously giving respiratory rate.Most of these methods needs a contact with the patient to efficiently measure the breathing rate.Unfortunately it leads to some issues which could forbid measurement or make it unconfortable for continuous monitoring.The continuous, every-day monitoring especially needs to be as discrete as possible to be forgotten by the patient.To deal wit…
Functional characterisation of the first HSP110 inhibitors.
2023
Heat shock proteins are molecular chaperones highly expressed in haematological malignancies. My laboratory has shown that the heat shock protein HSP110 is a new and important therapeutic target In colorectal cancer and in non-Hodgkin's lymphoma. As there were no existing inhibitors of HSP110, a screening strategy of a chemical library was carried out and allowed the identification of two molecules capable of specifically inhibiting the chaperone activity of HSP110. My thesis objective was to characterise and functionally validate these newly identified molecules in diffuse large cell B lymphomas. I have shown that one of these molecules limits the interaction of HSP110 with the SYK signall…
Aspetti emoreologici nella iperviscosità policitemica e sierica
2015
I fattori strutturali in grado di modificare la viscosità ematica sono la massa cellulare, le frazioni proteiche plasmatiche e la deformabilità del globulo rosso. In base alla presenza di uno di questi fattori si distinguono le diverse condizioni primarie di iperviscosità. Mentre l'iperviscosità policitemica è possibile riscontrarla in molti quadri clinici caratterizzati dall'aumento della massa cellulare (policitemia vera, eritrocitosi, leucocitosi iperleucocitiche, trombocitemia), l'iperviscosità sierica è probabile evidenziarla in quadri clinici diversi quali mieloma, malattia di Waldenstrom, crioglobulinemia, disfibrinogenemie, malattie del connettivo, e l'iperviscosità sclerocitemica è…
“Out of Sight, Out of Mind?”: The Role of Physical Stressors, Cognitive Appraisal, and Positive Emotions in Employees’ Health
2017
This study analyzes the mediating role of the appraisal of environmental stressors in the relationship between physical characteristics in the offices and health symptoms. It also studies the moderating role of positive emotions in the relationship between physical characteristics and the appraisal of environmental stressors using a diary study on 59 office workers ( n = 432 time points) and sensor data. The results show that the appraisal of environmental stressors mediates the relationship between physical office characteristics and health symptoms, emphasizing the important link of stress appraisal in the stressors–strain relationship. The results also show that positive emotions modera…
El enaltecimiento del terrorismo: desde el caso de Juana Chaos a César Strawberry. La recepción de la doctrina constitucional en la jurisprudencia de…
2020
The paper deals with the impact of the first ruling of the Constitutional Court on glorification of terrorism (112/2016) in the interpretation of this offence by the Supreme Court, which demands hermeneutically requirements absent from the literality of art. 578 of the Criminal Code and that the Constitutional Court required in its previous case law on hate speech, recently reiterated in the ruling 35/2020 of the Constitutional Court. Firstly, the text addresses the initial description of the elements of this criminal figure by the Supreme Court and its characterization as public defence without incitement, as opposed to the definition of the crime of public provocation to terrorism in the …
A measurement-based channel model for vehicular communications in tunnels
2014
Wireless Communications and Networking Conference (WCNC), 2014 IEEE, Istanbul, TURQUIE, 06-/04/2014 - 09/04/2014; In this paper, we present a new version of the iterative nonlinear least square approximation (INLSA) algorithm for the design of measurement-based channel simulators. The proposed method aims to match the time-variant impulse response (TVIR) of the simulation model to that of the measured channel. The propagation delays are discerned directly from the measurements, whereas the gains, the Doppler frequencies, and the phases are computed iteratively by minimizing a matching error norm. We evaluate the performance of the proposed method in terms of the approximation of the transfe…
Water and temperature contribution to the structuration of starch matrices in the presence of flavour
2015
The effect of hydrothermal treatments and flavours addition on starch structure and its physical properties were studied. Native wheat starch was treated at 2 different hydrations (water-starch ratios: 50/50 and 80/20 g w/w) and temperatures (65 and 85 °C) in the presence of flavours (ethyl hexanoate and 2-hexanone). The freshly prepared samples were subjected to DSC and flavour analysis. Flavour inclusion complex could not be detected by DSC, however the result of flavour analysis proved that there were flavours interactions with starch. Both ethyl hexanoate and 2-hexanone interacted with starch at similar rates. The highest flavour loss was found in the samples at high hydration and heate…
Estimating person parameters via item response model and simple sum score in small samples with few polytomous items: A simulation study
2018
Background The Item Response Theory (IRT) is becoming increasingly popular for item analysis. Theoretical considerations and simulation studies suggest that parameter estimates will become precise only by utilizing many items in large samples. Method A simulation study focusing on a single scale was performed on data with (a) n = 40, 60, 80, 120, 200, 300, 500, and 900 cases utilizing (b) 4, 8, 16, or 32 items. The items were (c) symmetrically distributed vs. skew (skewness 0, 1, and 2). Item loadings were (d) homogeneous vs. heterogeneous. Item loadings were (e) low vs. high. Half of the items had (f) a correlated error or not. The number of answering categories (g) was four vs. five. A to…
Ranking Scientific Journals Via Latent Class Models for Polytomous Item Response Data
2015
Summary We propose a model-based strategy for ranking scientific journals starting from a set of observed bibliometric indicators that represent imperfect measures of the unobserved ‘value’ of a journal. After discretizing the available indicators, we estimate an extended latent class model for polytomous item response data and use the estimated model to cluster journals. We illustrate our approach by using the data from the Italian research evaluation exercise that was carried out for the period 2004–2010, focusing on the set of journals that are considered relevant for the subarea statistics and financial mathematics. Using four bibliometric indicators (IF, IF5, AIS and the h-index), some…
Generalized Symmetry Models for Hypercubic Concordance Tables
2000
Summary Frequency data obtained classifying a sample of 'units' by the same categorical variable repeatedly over 'components', can be arranged in a hypercubic concordance table (h.c.t.). This kind of data naturally arises in a number of different areas such as longitudinal studies, studies using matched and clustered data, item-response analysis, agreement analysis. In spite of the substantial diversity of the mechanisms that can generate them, data arranged in a h.c.t. can all be analyzed via models of symmetry and quasi-symmetry, which exploit the special structure of the h.c.t. The paper extends the definition of such models to any dimension, introducing the class of generalized symmetry…