Search results for "JAK"

Role of JAK/STAT in Interstitial Lung Diseases; Molecular and Cellular Mechanisms

2021

Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway is activated under the interaction of a broad number of profibrotic/pro-inflammatory cytokines, such as IL-6, IL-11, and IL-13, among others, which are increased in different ILDs. Similarly, several growth factors over-expressed in ILDs, such as platelet-derived growth factor (PDGF), transforming growth factor β1 (TGF-β1), and fibroblast growth factor (FGF) activate JAK/STAT by canonical or non-canonical pathways, which indicates a predominant role of JAK/STAT in ILDs. Between the different JAK/STAT iso…

The adoption of photovoltaic micro production systems in Finland

2016

A sustainable supply of energy is one of the most important requirements in order to achieve sustainable development. By using renewable resources society is not dependent on depleting reserves, but instead can have an inexhaustible source of clean energy. The rapid development of photovoltaics has led to lowered prices and increased efficiency making them more attractive alternative as a source of household electricity. Although governments play a key role in setting the constraints of how renewable energy is adopted, the wide-spread adoption of distributed electricity production ultimately depends on consumer decisions to buy them. This study examined the adoption process of photovoltaic …

“Your ride has arrived” – Exploring the nexus between subjective well-being, socio-cultural beliefs, COVID-19, and the sharing economy

2021

This study aimed to identify and explain different facets of the sharing economy and to differentiate between micro- and macro-mobility services. We also aimed to examine the correlation between the sharing economy and subjective well-being, cultural beliefs, and COVID-19. An exploratory research technique with face-to-face semi-structured interviews was used to collect data from a sample of 22 rideshare app users in a developing country between January and May 2020 and in July 2020. The data were analyzed using the NVivo 12 application. The major findings suggest that, considering their scope and use, sharing economy technology and services can be divided into four major domains: (1) hospi…

Ankkalinna - portti kahden ulottuvuuden välillä fantastisten maailmojen ilmeneminen Don Rosan Disney-sarjakuvissa

2009

Kohti uutta Japania : Meiji-restauraatiota ympäröivän aikakauden 1853-1878 historiakuva Rurouni Kenshin-mangassa

2011

Tässä tutkimuksessa käsittelen japanilaisen Rurouni Kenshin –mangan tapaa käsitellä historiallisia tapahtumia ja henkilöitä, jotka liittyvät vuonna 1868 tapahtuneeseen Meiji-restauraatioon. Restauraation yhteydessä poliittinen valta palautettiin shogunilta keisarille vuosisatojen shogunaatin hallinnon jälkeen. Ajallisesti tutkimukseni käsittelee vuosia 1853–1878, aloittaen Japanin avautumisesta pitkän eristyskautensa jälkeen lopettaen vuoteen 1878. Vaikka sarjakuva ei ole perinteinen historian tutkimuslähde, sen kautta on mahdollista tutkia vallitsevia käsityksiä populaarikulttuurin välittämästä historiakuvasta. Tutkin myös, miten ja kuinka monipuolisesti Watsuki käsittelee aikakauden erila…

D'altro canto

2020

In occasione della ripubblicazione del volume "Lo sviluppo della semiotica" di R. Jakobson, curato da U. Eco, una riscostruzione storica e una revisione concettuale del rapporto tra linguistica e semiotica.

Switching Behaviour in Smart Phone Messaging Services : It’s a Question of Context, Content, and Features of the Service

2021

This paper studies switching behaviour in smart phone messaging services. This study aims to add knowledge about the factors affecting switching behaviour in smart phone messaging services. The empirical study is qualitative, and the data was collected with interviews using the laddering method. This study was carried out to find out the reasons behind customer decisions when choosing between smart phone messaging services. Using the Push-Pull Mooring framework, the findings of this study indicate that the switching decision regarding smart phone messaging service is influenced by three factors: the context of the message, the content of the message, and the features of the service.

Critica del Diritto Penale del Nemico e Tutela dei Diritti Umani

2010

La contrapposizione fra libertà e sicurezza ha assunto una rilevanza fondamentale per la trattazione della tutela universale dei diritti umani. Una delle teorie filosofico-penalistiche più controverse è il diritto penale del nemico, promossa da Günther Jakobs, avente ad oggetto lo stravolgimento della predominanza della tutela giuridica dell’individuo in quanto tale, qualora la vita dello Stato sia messa in pericolo da soggetti non considerati come cittadini, ma regrediti alla condizione di “nemici”. Il conflitto con i diritti umani è inevitabile, in quanto si legittimerebbe un sistema normativo volto alla selezione soggettiva dei criminali, distinguendo categorie di criminali-cittadini e c…

What drives customer satisfaction and well-being in ridesharing? : A developing country perspective

2019

This study examines ridesharing services from the customer perspective in a developing country context and investigates two significant post-adoption and marketing consequences: satisfaction and well-being. Using a purposeful sampling technique, six semi-structured in-depth interviews were conducted in Sindh province, Pakistan. Among the major findings are that customers’ awareness of the services and how to use the mobile application, convenience of use, high perceived value, the quality of information available in the ridesharing mobile app, real-time location services, and an effective complaint resolution mechanism promote customer satisfaction and well-being. This study includes implic…

Parental Burnout Across the Globe During the COVID-19 Pandemic

2022

Abstract. The COVID-19 pandemic has affected all societies worldwide. The heightened levels of stress that accompanied the crisis were also expected to affect parenting in many families. Since it is known that high levels of stress in the parenting domain can lead to a condition that has severe consequences for health and well-being, we examined whether the prevalence of parental burnout in 26 countries (9,923 parents; 75% mothers; mean age 40) increased during COVID-19 compared to few years before the pandemic. In most (but not all) countries, analyses showed a significant increase in the prevalence of parental burnout during the pandemic. The results further revealed that next to governm…