Search results for "JOINT"
showing 10 items of 1472 documents
Summary and recommendations of the OARSI FDA osteoarthritis Assessment of Structural Change Working Group
2011
Import JabRef | WosArea Orthopedics; Rheumatology; International audience; Objective: The Osteoarthritis Research Society International initiated a number of working groups to address a call from the US Food and Drug Administration (FDA) on updating draft guidance on conduct of osteoarthritis (OA) clinical trials. The development of disease-modifying osteoarthritis drugs (DMOADs) remains challenging. The Assessment of Structural Change (ASC) Working Group aimed to provide a state-of-the-art critical update on imaging tools for OA clinical trials. Methods: The Group focussed on the performance metrics of conventional radiographs (CR) and magnetic resonance imaging (MRI), performing systemati…
Comparative evaluation of three semi-quantitative radiographic grading techniques for knee osteoarthritis in terms of validity and reproducibility in…
2008
OBJECTIVE: The objective of this work was to compare the measurement properties of three categorical X-ray scoring methods of knee osteoarthritis (OA), both on semiflexed and extended views. METHODS: In data obtained from trials and cohorts, X-rays were graded using Kellgren and Lawrence (KL), the OA Research Society International (OARSI) joint space narrowing score, and measurement of joint space width (JSW). JSW was analyzed as a categorical variable. Construct validity was assessed through logistic regression between X-ray stages and Western Ontario and McMaster Universities OA Index. Inter-observer reliability was assessed in 50 subjects for extended views by weighted kappa. Intra-obser…
Performance of a historical cantilever reinforced concrete bridge with half-joint degradation
2022
The lack of maintenance of roadway concrete bridges built from the Second World War until the 70 s of the 20th century has led in recent years to an ever-increasing request for safety assessments. When bridge performance in terms of Serviceability Limit State (SLS) and Ultimate Limit State (ULS) has to be evaluated, in-situ visual inspections and load tests for safety and maintenance assessment have to be coupled with structural analysis. In order to identify a sound bridge structural model and to assess the actual conservation state, more refined models than those usually considered for section and reinforcement design should be used to reproduce the results of load tests and perform globa…
A probabilistic rainfall model to estimate the leading-edge lifetime of wind turbine blade coating system
2021
Rain-induced leading-edge erosion of wind turbine blades is associated with high repair and maintenance costs. For efficient operation and maintenance, erosion models are required that provide estimates of blade coating lifetime at a real scale. In this study, a statistical rainfall model is established that describes probabilistic distributions of rain parameters that are critical for site-specific leading-edge erosion assessment. A new droplet size distribution (DSD) is determined based on two years’ onshore rainfall data of an inland site in the Netherlands and the obtained DSD is compared with those from the literature. Joint probability distribution functions of rain intensities and dr…
Prosthetic modelling and simulation
2020
Abstract Modelling of physical systems can be divided into two categories: physical and mathematical modelling. Physical modelling is a process in which we construct tangible scale models that look very much like the real system. In the past century, consider the animal models that have significantly influenced the development of disease treatment and artificial joints. However, scale models require a great deal of time and resources to develop and there are limits to what can be learned from them. Mathematical or behavioural modelling is a more abstract system used for studying a research question that does not necessarily lend itself to physical modelling. In these models, the system is s…
The Influence of Context-Based Complexity on Decision Processes
2011
In this chapter, we present an empirical study which investigates the influence of context-based complexity on decision processes.1 To determine context-based complexity accurately, we measure each subject’s preferences individually with two advanced techniques from marketing research: choice-based conjoint analysis (CBC, Haaijer and Wedel 2007) and pairwise-comparison-based preference measurement (PCPM, Scholz et al. 2010), rather than relying on less precise estimates of preferences. Furthermore, we use eye tracking to trace the process of information acquisition precisely. Our results show that low context-based complexity leads to less information acquisition and more alternative-wise s…
Academic and Administrative Tandems in European Projects
2017
International audience; Building and maintaining the sustainability of European projects requires advanced communication and team investment, shared working methods, common decisions and symbiosis in key items such as selection requirement and process, terms of mobility between consortium members or teaching content. It requires jointness in various perspectives, aspects and scales, with their own conditions and challenges. This abstract describes this prerequisite of jointness through the local campus of Le Creusot (University of Burgundy) for our International Programme in Computer Vision and Robotics (VIBOT). The main challenge can be summarized in one single question: How to maintain an…
Requirements elicitation methods based on interviews in comparison: A family of experiments
2020
Abstract Context There are several methods to elicit requirements through interviews between an end-user and a team of software developers. The choice of the best method in this context is usually on subjective developers’ preferences instead of objective reasons. There is a lack of empirical evaluations of methods to elicit requirements that help developers to choose the most suitable one. Objective This paper designs and conducts a family of experiments to compare three methods to elicit requirements: Unstructured Interviews, where there is no specific protocol or artifacts; Joint Application Design (JAD), where each member of the development team has a specific role; Paper Prototyping, w…
Dealing with Product Similarity in Conjoint Simulations
2001
One of the reasons conjoint analysis has been so popular as a management decision tool has been the availability of a choice simulator. These simulators often arrive in the form of a software or spreadsheet program accompanying the output of a conjoint study. These simulators enable managers to perform ‘what if’ questions about their market—estimating market shares under various assumptions about competition and their own offerings. As examples, simulators can predict the market share of a new offering; they can estimate the direct and cross elasticity of price changes within a market, or they can form the logical guide to strategic simulations that anticipate short- and long-term competiti…
Joint Attention and Its Relationship with Autism Risk Markers at 18 Months of Age
2022
(1) Joint attention is the ability to coordinate attention to share a point of reference with another person. It has an early onset and is a clear indicator of understanding the representations of others, and it is essential in the development of symbolic thought and the acquisition of language. Deficiencies in this prelinguistic early communication skill are strong markers of the risk of autism spectrum disorder (ASD); (2) this longitudinal study aimed to evaluate joint attention skills in a group of 32 infants at two developmental moments (8 and 12 months) in order to explore whether their performance on this skill was related to the presence of early signs of ASD at 18 months. Logistic m…