Search results for "Javelin"
showing 6 items of 6 documents
Maintenance therapy with avelumab (MSB0010718C; anti-PD-L1) vs continuation of first-line chemotherapy in patients with unresectable, locally advance…
2016
TPS4134Background: Programmed death-1 receptor ligand (PD-L1) is a key therapeutic target in the reactivation of the immune response against multiple cancers. Avelumab* is a fully human anti-PD-L1 ...
Results of the JAVELIN Gastric 100 phase 3 trial: avelumab maintenance following first-line (1L) chemotherapy (CTx) vs continuation of CTx for HER2-a…
2020
278 Background: We report the primary analysis of JAVELIN Gastric 100, which compared avelumab (anti–PD-L1) maintenance after 1L CTx vs continued CTx in patients (pts) with GC/GEJC. Methods: In this global, open-label, phase 3 trial (NCT02625610), eligible pts had previously untreated, unresectable, locally advanced/metastatic (LA/M) HER2− GC/GEJC. Pts without progressive disease (PD) after 12 weeks of 1L oxaliplatin/fluoropyrimidine induction were randomized 1:1 to avelumab 10 mg/kg Q2W switch maintenance or continued CTx, stratified by region (Asia vs non-Asia). Primary endpoint was overall survival (OS) post induction in all randomized or PD-L1+ (≥1% of tumor cells, 73-10 assay) pts. Re…
Food Habits of the Javelin Sand Boa Eryx jaculus (Linnaeus 1758; Serpentes, Erycidae) in Sicily, Italy
2021
The Javelin Sand Boa, Eryx jaculus, is reported to be a predator of mammals, lizards and their eggs, and occasionally of birds and invertebrates, but data on its diet are scarce and fragmentary. Here we describe some aspects of the feeding behavior of E. jaculus on the Mediterranean island of Sicily. A total of 132 individual snakes were examined. Prey remains were found in 43% of them, both in their feces (82.5%) and gut contents (17.5%). The number of snakes observed and their feeding rate decreased in August, probably as a result of the relatively higher temperatures. Feeding rate increases were observed in adult females in September, perhaps to enhance body reserves before hibernation. …
Nuovi dati sulla presenza di Eryx jaculus (Linnaeus, 1758) in Sicilia
2017
The javelin sand boa {Eryx jaculus) is a snake belonging to the Erycidae family, distributed in North Africa, southern Balkans and the Middle East. Recently its presence was confirmed in Italy, in a small area along the coast of south-central Sicily, in the territories of Licata (province of Agrigento). This paper reports the current distribution area, of about 52 km2, obtained by the Minimum Convex Polygon method, using recent bibliographical ob-servations and three new observations carried out between 15 August 2014 and 30 Aprii 2016. The new findings are located east of the known Sicilian distribution area and indicate for the first time the presence of the javelin sand boa in the provin…
Phase III Trial of Avelumab Maintenance After First-Line Induction Chemotherapy Versus Continuation of Chemotherapy in Patients With Gastric Cancers:…
2021
PURPOSE The role of maintenance therapy for gastric (GC) or gastroesophageal junction cancer (GEJC) is unclear. We investigated avelumab (anti–programmed death ligand-1 [PD-L1]) maintenance after first-line induction chemotherapy for GC/GEJC. PATIENTS AND METHODS JAVELIN Gastric 100 was a global, open-label, phase III trial. Eligible patients had untreated, unresectable, human epidermal growth factor receptor 2–negative, locally advanced or metastatic GC or GEJC. Patients without progressive disease after 12 weeks of first-line chemotherapy with oxaliplatin plus a fluoropyrimidine were randomly assigned 1:1 to avelumab 10 mg/kg every 2 weeks or continued chemotherapy, stratified by region (…
2020
Although the individuality of whole-body movements has been suspected for years, the scientific proof and systematic investigation that individuals possess unique movement patterns did not manifest until the introduction of the criteria of uniqueness and persistence from the field of forensic science. Applying the criteria of uniqueness and persistence to the individuality of motor learning processes requires complex strategies due to the problem of persistence in the learning processes. One approach is to examine the learning process of different movements. For this purpose, it is necessary to differentiate between two components of movement patterns: the individual-specific component and …