Search results for "Juva"
showing 9 items of 739 documents
COMPliance and Arthralgia in Clinical Therapy: the COMPACT trial, assessing the incidence of arthralgia, and compliance within the first year of adju…
2014
5 Office-based Professional Association Gynecologic Oncologists e.V. in Germany (BNGO e.V.), Berlin; 6 Background: This prospective study evaluated the relationship between arthralgia and compliance during the first year of adjuvant anastrozole therapy in postmenopausal women with hormone receptor-positive early breast cancer. Patients and methods: COMPliance and Arthralgia in Clinical Therapy (COMPACT) was an open-label, multicenter, noninterventional study conducted in Germany. Patients had started adjuvant anastrozole 3-6 months before the study start. The primary end points were arthralgia, compliance, and the relationship between compliance and arthralgia, assessed at specific time poi…
Chemopreventive and Anticancer Role of Resveratrol against Oral Squamous Cell Carcinoma
2023
Oral squamous cell carcinoma (OSCC) is one of the most prevailing and aggressive head and neck cancers, featuring high morbidity and mortality. The available conventional treatments suffer from several adverse effects and are often inefficient in terms of their survival rates. Thus, seeking novel therapeutic agents and adjuvants is of the utmost importance for modern society. Natural polyphenolic compounds have recently emerged as promising chemopreventive and anticancer agents. Specifically, the natural compound resveratrol (RSV) has recently gained momentum for this purpose. RSV is useful for treating OSCC due to its antiproliferative, antimetastatic, and proapoptotic effects. Additionall…
Destroying the Shield of Cancer Stem Cells: Natural Compounds as Promising Players in Cancer Therapy
2022
In a scenario where eco-sustainability and a reduction in chemotherapeutic drug waste are certainly a prerogative to safeguard the biosphere, the use of natural products (NPs) represents an alternative therapeutic approach to counteract cancer diseases. The presence of a heterogeneous cancer stem cell (CSC) population within a tumor bulk is related to disease recurrence and therapy resistance. For this reason, CSC targeting presents a promising strategy for hampering cancer recurrence. Increasing evidence shows that NPs can inhibit crucial signaling pathways involved in the maintenance of CSC stemness and sensitize CSCs to standard chemotherapeutic treatments. Moreover, their limited toxici…
Adjuvant capecitabine in triple negative breast cancer patients with residual disease after neoadjuvant treatment: real-world evidence from CaRe, a m…
2023
BackgroundIn triple negative breast cancer patients treated with neoadjuvant chemotherapy, residual disease at surgery is the most relevant unfavorable prognostic factor. Current guidelines consider the use of adjuvant capecitabine, based on the results of the randomized CREATE-X study, carried out in Asian patients and including a small subset of triple negative tumors. Thus far, evidence on Caucasian patients is limited, and no real-world data are available.MethodsWe carried out a multicenter, observational study, involving 44 oncologic centres. Triple negative breast cancer patients with residual disease, treated with adjuvant capecitabine from January 2017 through June 2021, were recrui…
Efficacy of one-year maintenance in early adjuvant chemotherapy for intermediate risk non-muscle-invasive bladder cancer. Preliminary results of a ra…
2008
Introduction and Objective: The clinical value of early intravesical adjuvant chemotherapy after TUR of intermediate risk non-muscle-invasive bladder cancer (NMI TCCB) is well established. On the other hand, the optimal schedule regimen and the role of maintenance are still debated. The aim of the present study was to evaluate the effectiveness of one-year maintenance schedule in patients submitted to TUR plus adjuvant early intravesical chemotherapy. Methods: Between May 2002 and August 2003, 577 patients, were recruited. All patients underwent TUR and early (within 6 hours) intravesical chemotherapy with epirubicin at the dose of 80 mg diluted in 60 ml of saline solution. When histology w…
Adherence to oral hormonal anticancer agents in breast cancer.
2022
There is an increasing trend towards using oral antitumoral agents in oncological patients. Compared to parenteral therapy, oral treatment offers convenience for both the patient and the healthcare system, with similar efficacy. However, the benefit deriving from oral drugs will be obtained only if patients adhere strictly to the treatment. Medical oncologists must therefore seek to optimize patient adherence. Breast cancer patients, particularly, are often treated with oral hormonal anticancer agents. In this review, we summarized evidence about adherence of breast cancer patients to oral hormonal anticancer agents and the consequences of poor compliance, the barriers to oral treatment an…
Gremošanas sistēmas akūtās blaknes onkoloģiskiem pacientiem, saņemot neoadjuvanto mērķterapiju
2020
Bakalaura darba tēma ir “Gremošanas sistēmas akūtas blaknes onkoloģiskiem pacientiem, saņemot neoadjuvantu terapiju”. Bakalaura darba mērķis ir novērtēt akūtas gremošanas sistēmas blaknes onkoloģiskiem pacientiem saņemot tikai staru terapiju vai kombinētu neoadjuvantu mēķterapiju ar taisnās zarnas un tūpļa kanāla audzējiem, balstoties uz RTOG skalas. Bakalaura darbs sastāv no teorijas daļas un pētījuma daļas. Darba apjoms ir 43 lpp. Bakalaura darbā izvirzīta hipotēze ir agrīnas staru terapijas blaknes attīstīsies agrāk un būs smagākas pacientiem, kuri vienlaicīgi saņem staru terapiju un ķīmijterapiju. Pētījuma daļā tika pielietota kvalitatīvi prospektīva pētījuma metode, ar kuras palīdzību …
La Reggia di Venaria Reale in Italy and Palacio Real de Aranjuez in Spain: history, restoration and significance, comparative study between Two Royal…
2017
La investigación relaciona dos sitios reales, La Reggia di Venaria Reale en Italia y el Palacio Real de Aranjuez en España, confrontando su desarrollo histórico y arquitectónico, las obras de restauración llevadas a cabo, los criterios para su inclusión en la Lista de Patrimonio Mundial y su uso hoy en día como museos. El estudio comparativo muestra cómo ambos palacios se usaban inicialmente como residencias de caza en lugares con abundancia de agua y pesca. Además, los dos están ubicados cerca de las capitales políticas de su tiempo; esto es, Turín y Madrid. El hecho que el mismo arquitecto – Filippo Juvarra estuviera presente en ambas residencias reales contribuye a las similitudes, y en …
Obesity and survival in operable breast cancer patients treated with adjuvant anthracyclines and taxanes according to pathological subtypes: a pooled…
2013
Obesity is an unfavorable prognostic factor in breast cancer (BC) patients regardless of menopausal status and treatment received. However, the association between obesity and survival outcome by pathological subtype requires further clarification. METHODS: We performed a retrospective analysis including 5,683 operable BC patients enrolled in four randomized clinical trials (GEICAM/9906, GEICAM/9805, GEICAM/2003-02, and BCIRG 001) evaluating anthracyclines and taxanes as adjuvant treatments. Our primary aim was to assess the prognostic effect of body mass index (BMI) on disease recurrence, breast cancer mortality (BCM), and overall mortality (OM). A secondary aim was to detect differences o…