Search results for "KIF4A"

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Aneuploid IMR90 cells induced by depletion of pRB, DNMT1 and MAD2 show a common gene expression signature

2019

Chromosome segregation defects lead to aneuploidy which is a major feature of solid tumors. How diploid cells face chromosome mis-segregation and how aneuploidy is tolerated in tumor cells are not completely defined yet. Thus, an important goal of cancer genetics is to identify gene networks that underlie aneuploidy and are involved in its tolerance. To this aim, we induced aneuploidy in IMR90 human primary cells by depleting pRB, DNMT1 and MAD2 and analyzed their gene expression profiles by microarray analysis. Bioinformatic analysis revealed a common gene expression profile of IMR90 cells that became aneuploid. Gene Set Enrichment Analysis (GSEA) also revealed gene-sets/pathways that are …

DNA (Cytosine-5-)-Methyltransferase 1AneuploidyBiologyMicroarrayReal-Time Polymerase Chain ReactionRetinoblastoma ProteinCell LineRNA interferenceGene expressionProtein Interaction MappingGeneticsmedicineHumansGeneOligonucleotide Array Sequence AnalysisMicroarray analysis techniquesGene Expression ProfilingBioinformatics analysiChromosomeFibroblastsmedicine.diseaseAneuploidyGene Expression RegulationRNAiMad2 ProteinsDNMT1Cancer researchKIF4ARNA InterferenceTranscriptomeIMR90 human fibroblast
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