Search results for "KNOWLEDGE"
showing 10 items of 3108 documents
Development and Validation of the OSA-CPAP Perceived Competence Evaluation Interview
2021
Continuous positive airway pressure (CPAP) is one of the most common therapies for Obstructive Sleep Apnea (OSA). We present a brief, patient-reported outcome measure used to assess patients' levels of adherence with CPAP treatment.A questionnaire was developed based on academic literature. We qualitatively tested a pool of 18 items. It was tested in a sample of 174 patients from the Hospital La Princesa. Next, 1021 patients from Catalonia were evaluated.5 items were removed. Nominal groups referred to three areas: general knowledge about OSA and its risks; CPAP treatment information and expectations; CPAP use, monitoring, and confidence with its use. The 13 retained items maintained the sa…
An Algebraic Approach to Knowledge Representation
1999
This paper is an attempt to apply domain-theoretic ideas to a new area, viz. knowledge representation. We present an algebraic model of a belief system. The model consists of an information domain of special kind (belief algebra) and a binary relation on it (entailment). It is shown by examples that several natural belief algebras are, essentially, algebras of flat records. With an eye on this, we characterise those domains and belief algebras that are isomorphic to domains or algebras of records. For illustration, we suggest a system of axioms for revision in such a model and describe an explicit construction of what could be called a maxichoise revision.
A Context-Aware System for Ambient Assisted Living
2017
In the near future, the world's population will be characterized by an increasing average age, and consequently, the number of people requiring for a special household assistance will dramatically rise. In this scenario, smart homes will significantly help users to increase their quality of life, while maintaining a great level of autonomy. This paper presents a system for Ambient Assisted Living (AAL) capable of understanding context and user's behavior by exploiting data gathered by a pervasive sensor network. The knowledge inferred by adopting a Bayesian knowledge extraction approach is exploited to disambiguate the collected observations, making the AAL system able to detect and predict…
Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspecti…
2021
International audience; Extracellular vesicles (EV) are emergent therapeutic effectors that have reached clinical trial investigation. To translate EV-based therapeutic to clinic, the challenge is to demonstrate quality, safety, and efficacy, as required for any medicinal product. EV research translation into medicinal products is an exciting and challenging perspective. Recent papers, provide important guidance on regulatory aspects of pharmaceutical development, defining EVs for therapeutic applications and critical considerations for the development of potency tests. In addition, the ISEV Task Force on Regulatory Affairs and Clinical Use of EV-based Therapeutics as well as the Exosomes C…
The correlation between intellectual property management and quality management in the modern knowledge-based economy
2018
The aim of this research paper is to highlight the intellectual property place and role within an industrial knowledge-based organization which performs design activities. The research begins by presenting the importance of integrating intellectual property policy implementation with quality policy. The research is based on the setting of objectives in the intellectual property field. This research also establishes some intellectual property strategies, and improvement measures for intellectual property protection management. The basis for these activities is correlation of the quality policy with an intellectual property policy, as well as the point of strength identified in the studied or…
An AMI System for User Daily Routine Recognition and Prediction
2014
Ambient Intelligence (AmI) defines a scenario involving people living in a smart environment enriched by pervasive sensory devices with the goal of assisting them in a proactive way to satisfy their needs. In a home scenario, an AmI system controls the environment according to a user’s lifestyle and daily routine. To achieve this goal, one fundamental task is to recognize the user’s activities in order to generate his daily activities profile. In this chapter, we present a simple AMI system for a home scenario to recognize and predict users’ activities. With this predictive capability, it is possible to anticipate their actions and improve their quality of life. Our approach uses a Hidden M…
Molecular topology as a novel approach for drug discovery
2012
Molecular topology (MT) has emerged in recent years as a powerful approach for the in silico generation of new drugs. One key part of MT is that, in the process of drug design/discovery, there is no need for an explicit knowledge of a drug's mechanism of action unlike other drug discovery methods.In this review, the authors introduce the topic by explaining briefly the most common methodology used today in drug design/discovery and address the most important concepts of MT and the methodology followed (QSAR equations, LDA, etc.). Furthermore, the significant results achieved, from this approach, are outlined and discussed.The results outlined herein can be explained by considering that MT r…
Assessing the Impact of DMAIC-Knowledge Management Methodology on Six Sigma Projects: An Evaluation through Participant’s Perception
2014
As an emerging concept, Knowledge Management (KM) has a great impact on organization and organizational performance. On the other hand, DMAIC is a well known methodology, used for solving organizational problems through Six Sigma projects.The main purpose of this study is to assess the impact of newly proposed DMAIC-KM integrated methodology in executing Six Sigma projects. For assessment, four Six Sigma projects have been executed using DMAIC-KM methodology within an airbag manufacturing unit. Afterward, the Opinion and Perception have been collected from the Project participant’s through conducting a quantitative survey regarding the Organizational benefits achieved after executing the DM…
Application of latent class analysis in assessing the awareness, attitude, practice and satisfaction of paediatricians on sleep disorder management i…
2020
Aim To identify subgroups regarding paediatricians’ awareness, attitude, practice and satisfaction about management of Sleep-Disordered Breathing (SDB) in Italy using Latent Class Analysis (LCA). Methods A cross-sectional study was conducted on a large sample of Italian paediatricians. Using a self-administered questionnaire, the study collected information on 420 Paediatric Hospital Paediatricians (PHPs) and 594 Family Care Paediatricians (FCPs). LCA was used to discover underlying response patterns, thus allowing identification of respondent groups with similar awareness, attitude, practice and satisfaction. A logistic regression model was used to investigate which independent variables i…
Knowledge, opinions and attitudes of Italian mothers towards HPV vaccination and Pap test
2015
Aim This study evaluated the knowledge and attitudes of Italian mothers – whose daughters had been vaccinated in 2012 – towards primary (anti-HPV vaccination) and secondary (Pap test screening) cervical cancer prevention, as well as sources of information and mother-daughter communication on health issues. Methods The survey – part of a multicenter study carried out in 4 Italian cities (Ferrara, Rome, Cassino and Palermo) – was conducted through self-administered questionnaires. The first univariate analysis evaluated differences between mothers of under-18s and over-18s relative to knowledge and attitudes on HPV vaccination and Pap test. The second univariate analysis evaluated differences…