Search results for "Kaposi sarcoma"

showing 3 items of 13 documents

Prevalence of Toscana and Sicilian Phlebovirus Antibodies in Classic Kaposi Sarcoma Case Patients and Control Subjects in Sicily

2011

To assess whether arthropod bites promote Kaposi sarcoma (KS), we determined the seroprevalence of Sicilian (SFSV) and Toscana (TOSV) phlebovirus antibodies in 30 patients with classic KS and 100 controls in Sicily. Nine (6.9%) subjects, all controls, were positive for SFSV, whereas 41 (31.5%) were positive for TOSV. Seroprevalence with immunoglobulin (Ig) M or IgG against either virus was significantly higher in controls (43% vs 13.3% in case patients; P < .01). Adjusted for age, IgG seroprevalence was significantly lower in KS patients compared to controls (adjusted odds ratio, 0.22; 95% confidence interval, .07–.72). Low phlebovirus seroprevalence in patients with KS may reflect incapaci…

MalePhlebovirusphlebovirus classic Kaposi sarcoma SicilyComorbidityBiologyAntibodies ViralSettore MED/42 - Igiene Generale E ApplicataImmunoglobulin GVirusMajor Articles and Brief ReportsSeroepidemiologic StudiesHumansImmunology and AllergySeroprevalenceSarcoma KaposiAgedAged 80 and overClassic Kaposi SarcomaOdds ratioMiddle Agedbiology.organism_classificationVirologyInfectious DiseasesImmunoglobulin MItalyPhlebovirusImmunoglobulin MImmunoglobulin GHerpesvirus 8 HumanImmunologybiology.proteinFemaleAntibodyThe Journal of Infectious Diseases
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Delayed-type hypersensitivity in classic Kaposi sarcoma patients and controls

2011

Background: Immune perturbation likely affects the development of Kaposi sarcoma (KS) among people infected with the KS-associated herpesvirus (KSHV). We tested whether KSHV-seropositive individuals or cases of classic KS (cKS), which typically originates in the leg, had differing delayed-type hypersensitivity (DTH) in the forearm or leg. Methods: Mantoux DTH with three antigens (Candida, tetanus, PPD) was performed on the forearm and leg of 15 cKS cases, 14 KSHV-positives without KS, and 15 KSHV-negative controls. The diameters of induration responses were compared by group and body site. Results: Leg DTH was greater than forearm DTH among controls (mean difference 5.6 mm, P=0.0004), where…

MaleherpesvirusesCancer ResearchAllergyherpesvirusedelayed-type hypersensitivitySettore MED/42 - Igiene Generale E ApplicataForearmAntigenImmunopathologymedicineHumansHypersensitivity DelayedSarcoma KaposiAgedLegClassic Kaposi Sarcomaintegumentary systembusiness.industryKaposi sarcomamedicine.diseasebody regionsTransplantationForearmhuman immunodeficiency virus (HIV)medicine.anatomical_structureOncologyItalyDelayed hypersensitivityHerpesvirus 8 HumanImmunologyClinical StudyFemaleSarcomabusinesstransplantation
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A Multiplex Panel of Plasma Markers of Immunity and Inflammation in Classical Kaposi Sarcoma

2014

Kaposi sarcoma (KS) risk is affected by perturbed immunity. Herein, we compared plasma from 15 human immunodeficiency virus (HIV)–negative classic KS cases to plasma from 29 matched controls, using a multiplex panel of immunity markers. Of 70 markers, CXCL10 (IP-10), sIL-1RII, sIL-2RA, and CCL3 (MIP-1A) were strongly and significantly associated with KS, after adjustment for age and smoking status. These and previous observations are consistent with a tumor-promoting role for these cytokines, particularly CXCL10, but the small sample size and case-control design preclude firm conclusions on KS risk or pathogenesis. Larger, well-designed prospective studies are needed to better assess the as…

Malemedicine.medical_treatmentInflammationBiologySettore MED/42 - Igiene Generale E ApplicataPathogenesisKaposi SarcomaPlasma Markers of InflammationMajor Articles and Brief ReportsImmunitymedicineHumansImmunology and AllergyProspective cohort studySarcoma KaposiInflammationCase-control studyvirus diseasesPlasma Markers of Immunitymedicine.diseaseSquamous intraepithelial lesionInfectious DiseasesCytokineItalyCase-Control StudiesImmunologySarcomamedicine.symptomBiomarkers
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