Search results for "Kara"
showing 10 items of 164 documents
Efficient Delivery of Human Cytomegalovirus T Cell Antigens by Attenuated Sendai Virus Vectors.
2018
ABSTRACT Human cytomegalovirus (HCMV) represents a major cause of clinical complications during pregnancy as well as immunosuppression, and the licensing of a protective HCMV vaccine remains an unmet global need. Here, we designed and validated novel Sendai virus (SeV) vectors delivering the T cell immunogens IE-1 and pp65. To enhance vector safety, we used a replication-deficient strain (rdSeV) that infects target cells in a nonproductive manner while retaining viral gene expression. In this study, we explored the impact that transduction with rdSeV has on human dendritic cells (DCs) by comparing it to the parental, replication-competent Sendai virus strain (rcSeV) as well as the poxvirus …
Managing adult patients with infectious diseases in emergency departments: international ID-IRI study.
2021
We aimed to explore factors for optimizing antimicrobial treatment in emergency departments. A single-day point prevalence survey was conducted on January 18, 2020, in 53 referral/tertiary hospitals in 22 countries. 1957 (17%) of 11557 patients presenting to EDs had infections. The mean qSOFA score was 0.37 +/- 0.74. Sepsis (qSOFA >= 2) was recorded in 218 (11.1%) patients. The mean qSOFA score was significantly higher in low-middle (1.48 +/- 0.963) compared to upper-middle (0.17 +/- 0.482) and high-income (0.36 +/- 0.714) countries ( P < 0.001). Eight (3.7%) patients with sepsis were treated as outpatients. The most common diagnoses were upper-respiratory (n = 877, 43.3%), lower-respirator…
Trichomonicidal and parasite membrane damaging activity of bidesmosic saponins from Manilkara rufula.
2017
The infection caused by Trichomonas vaginalis is the most common but overlooked non-viral sexually transmitted disease worldwide. Treatment relies on one class of drugs, the 5-nitroimidazoles, but resistance is widespread. New drugs are urgently needed. We reported the effect of crude and purified saponin fractions of Manilkara rufula against Trichomonas vaginalis. The compound responsible for antitrichomonal activity was isolated and identified as an uncommon bidesmosic saponin, Mi-saponin C. This saponin eliminated parasite viability without toxicity against the human vaginal epithelial line (HMVII). In addition, the isolated saponin fraction improved the metronidazole effect against a me…
Flying-Related Concerns among Airline Customers in Finland and Sweden during COVID-19
2022
COVID-19 hit the global economy hard in early 2020, and airline industry was among the biggest commercial victims. Governments closed borders, the virus scared off travelers and the aircraft stayed on the ground to a large extent. The forecasted record year turned out to be the worst in the history of aviation. This study focused on the concerns of airline customers and analyzed the differences between the customer behavior in two focus markets, Finland and Sweden. The article is based on a questionnaire and the answers of 2004 airline customers. The results show that even though the overall COVID-19 strategy was very different between the focus markets, the same concerns still arose. The m…
Latvijas Vēstures Institūta Žurnāls. 2015, Nr. 1 (94)
2015
Valsts kultūrkapitāla fonds
Latvijas Vēstures Institūta Žurnāls. 2009, Nr. 2 (71)
2009
Latvijas Vēstures Institūta Žurnāls. 2021, Nr. 1 (113)
2021
LU Latvijas vēstures institūta LU ilgtermiņa saistību izpilde 2020.-2022. g. ("Latvijas Vēstures Institūta Žurnāls")
Azerbaidžānas tiesības pielietot pašaizsardzību Kalnu Karabahas kontekstā
2021
Pašaizsardzības tiesību izmantošana ilgstoši okupētas teritorijas atgūšanai ir pievērsusi starptautisko tiesību zinātnieku interesi jo īpaši pēc tam, kad 2020. gada septembrī atsākās karadarbība Kalnu Karabahas reģionā. Bakalaura darba mērķis ir noskaidrot, vai Azerbaidžānai bija tiesības īstenot pašaizsardzību 2020. gada septembra konfliktā, lai atgūtu okupētās teritorijas. Līdz ar to autore vispusīgi iepazīsies ar zinātnisko literatūru, kurā skaidroti Statūtu 2. panta ceturtās daļas un 51. panta tvērumi, tāpat tiks aplūkota arī ANO Starptautiskās Tiesas prakse, lai darba noslēgumā sniegtu atbildi par šādu Azerbaidžānas tiesību pastāvēšanu.
Capacity assessment for provision of quality sexual reproductive health and HIV-integrated services in Karamoja, Uganda
2020
Introduction: Sexual and reproductive health (SRH) and Human Immunodeficiency Virus (HIV) are crucial global health issues. Uganda continues to sustain a huge burden of HIV and AIDS.
 Methods: A cross-sectional health facility-based assessment was performed in November and December 2016 in Karamoja Region, northern Uganda. All the 126 health facilities (HFs) in Karamoja, including 5 hospitals and 121 Health Centers (HCs), covering 51 sub-counties of the 7 districts were assessed. We assessed the capacity of a) leadership and governance, b) human resource, c) service delivery, d) SRH and HIV service integration and e) users satisfaction and perceptions.
 Results: 64% of the establi…
Latviešu Afganistānas kara veterānu dzīvesstāsti: mutvārdu vēstures interviju un atmiņu analīze
2018
Bakalaura darba „Latviešu Afganistānas kara veterānu dzīvesstāsti: mutvārdu vēstures interviju un atmiņu analīze” mērķis ir pētīt Afganistānas kara veterānu atmiņu mutvārdu vēstures liecībās un komunikācijā par karā piedzīvoto un tā ietekmi uz turpmāko dzīvi. Izmantojot daļēji strukturētas intervijas, tika iegūtas mutvārdu vēstures liecības par piecu latviešu kararvīru pieredzi Afganistānas karā. Tāpat tika veikts novērojums. Lai analizētu iegūto informāciju, bakalaura darbā izmantota kvalitatīvā kontentanalīze. Darbā teorētisko pamatu veido kolektīvās atmiņas un kultūras traumas teorijas. Veicot pētījumu, tika secināts, ka Afganistānas karu veterāni atminas kā iespēju iekļauties sava laika…