Search results for "Keratin-14"

showing 3 items of 3 documents

Ectopic expression of desmin in the epidermis of transgenic mice permits development of a normal epidermis.

2002

Cell architecture is largely based on the interaction of cytoskeletal proteins, which include intermediate filaments (IF), microfilaments, microtubules, as well as their type-specific membrane-attachment structures and associated proteins. In order to further our understanding of IF proteins and to address the fundamental issue whether different IF perform unique functions in different tissues, we expressed a desmin transgene in the basal epidermis of mice. Ectopic expression of desmin led to the formation of an additional, keratin-independent IF cytoskeleton and did not interfere with the keratin-desmosome interaction. We show that ectopic expression of a type III IF protein in basal kerat…

KeratinocytesCancer ResearchCellular differentiationMice Transgenicmacromolecular substancesBiologyDesminMiceKeratinmedicineAnimalsHumansIntermediate filamentCytoskeletonMolecular Biologychemistry.chemical_classificationEpidermis (botany)Keratin-14Cell BiologyImmunohistochemistryCell biologyDisease Models Animalmedicine.anatomical_structurePhenotypechemistryEpidermolysis Bullosa SimplexImmunologyKeratinsEctopic expressionDesminEpidermisKeratinocyteDevelopmental BiologyDifferentiation; research in biological diversity
researchProduct

Determination of cytokeratins 1, 13 and 14 in oral lichen planus

2014

Cytokeratins (CK) are molecules of the cytoskeleton that contribute to the cellular differenciation. We studied the expression of CK1, CK13 and CK14 in thirty-three patients with OLP. The biopsied lesions were located in the dorsal surface of the tongue, the palatal keratinized mucosa and the nonkeratinized buccal mucosa. Objectives: This study aimed to determine the expression of CK1, CK13 and CK14 in oral lichen planus (OLP) and its relations with: clinical patterns, prognosis, drugs and tobacco intake and histopathological features. Study Design: Immunohistochemical analysis, retrospective, descriptive, observational and no randomized study. Results: No significant difference was observe…

MalePathologyMedicina ClínicaBasal (phylogenetics)//purl.org/becyt/ford/3.2 [https]Aged 80 and overMiddle Aged:CIENCIAS MÉDICAS [UNESCO]ImmunohistochemistryCiencias de la saludmedicine.anatomical_structureUNESCO::CIENCIAS MÉDICASORAL LICHEN PLANUS//purl.org/becyt/ford/3 [https]FemaleAdultmedicine.medical_specialtyCIENCIAS MÉDICAS Y DE LA SALUDCK1CYTOKERATINOdontologíaBASAL CELL VACUOLIZATIONOdontología Medicina y Cirugía OralCytokeratinstomatognathic systemTongueOral and maxillofacial pathologymedicineHumansGeneral DentistryAgedRetrospective StudiesCK13Oral Medicine and Pathologybusiness.industryCK14ResearchKeratin-13Keratin-14medicine.diseaseOrthokeratosisEpitheliumLYMPHOCYTIC EXOCYTOSISstomatognathic diseasesOtorhinolaryngologyVacuolizationSurgeryOral lichen planusbusinessKeratin-1Lichen Planus Oral
researchProduct

Focal adhesions are hotspots for keratin filament precursor formation

2006

Recent studies showed that keratin filament (KF) formation originates primarily from sites close to the actin-rich cell cortex. To further characterize these sites, we performed multicolor fluorescence imaging of living cells and found drastically increased KF assembly in regions of elevated actin turnover, i.e., in lamellipodia. Abundant KF precursors (KFPs) appeared within these areas at the distal tips of actin stress fibers, moving alongside the stress fibers until their integration into the peripheral KF network. The earliest KFPs were detected next to actin-anchoring focal adhesions (FAs) and were only seen after the establishment of FAs in emerging lamellipodia. Tight spatiotemporal …

TalinKeratin 14Intermediate Filamentsmacromolecular substancesBiologyTransfectionKeratin 18Cell LineFocal adhesionMiceReportStress FibersCell cortexMetalloproteinsAnimalsHumansRNA AntisensePseudopodiaCytoskeletonActinResearch ArticlesCell Line TransformedFocal AdhesionsKeratin FilamentKeratin-18Keratin-14Cell BiologyBridged Bicyclo Compounds HeterocyclicActinsZyxinCell biologyProtein TransportThiazolesBiochemistryEpidermolysis Bullosa SimplexMutationKeratinsThiazolidinesMarine ToxinsLamellipodiumPaxillinThe Journal of Cell Biology
researchProduct