Search results for "Key"
showing 10 items of 1962 documents
Sampled Fictitious Play on Networks
2019
We formulate and solve the problem of optimizing the structure of an information propagation network between multiple agents. In a given space of interests (e.g., information on certain targets), each agent is defined by a vector of their desirable information, called filter, and a vector of available information, called source. The agents seek to build a directed network that maximizes the value of the desirable source-information that reaches each agent having been filtered en route, less the expense that each agent incurs in filtering any information of no interest to them. We frame this optimization problem as a game of common interest, where the Nash equilibria can be attained as limit…
Conceptual Key Competency Model for Smart Factories in Production Processes
2020
Abstract Background and Purpose: The aim of the study is to develop a conceptual key competency model for smart factories in production processes, focused on the automotive industry, as innovation and continuous development in this industry are at the forefront and represent the key to its long-term success. Methodology: For the purpose of the research, we used a semi-structured interview as a method of data collection. Participants were segmented into three homogeneous groups, which are industry experts, university professors and secondary education teachers, and government experts. In order to analyse the qualitative data, we used the method of content analysis. Results: Based on the anal…
The Integration of the Supply Chain as a Dynamic Capability for Sustainability: The Case of an Innovative Organic Company
2018
Numerous research projects have demonstrated that a firm’s ability to integrate, build, and reconfigure internal and external competencies to adapt to changes in its environment is a key capability for its competitiveness. However, in the case of developing the capabilities needed to implement innovation, we have found that the ability to integrate knowledge into the supply chain is also crucial since it is an essential requirement for bringing in technological change and product innovation. The purpose of this chapter is to understand the role of supplier integration in the implementation of radical innovation. First, we propose a theoretical model to connect supplier integration as a dyna…
Two novel subjective logic-based in-network data processing schemes in wireless sensor networks
2016
Wireless sensor networks (WSNs) consist of connected low-cost and small-size sensor nodes. The sensor nodes are characterized by various limitations, such as energy availability, processing power, and storage capacity. Typically, nodes collect data from an environment and transmit the raw or processed data to a sink. However, the collected data contains often redundant information. An in-network processing scheme attempts to eliminate or reduce such redundancy in sensed data. In this paper, we propose two in-network data processing schemes for WSNs, which are built based on a lightweight algebra for data processing. The schemes bring also benefits like decreased network traffic load and inc…
Local expert experiences and perceptions of environmentally induced migration from Bangladesh to India
2017
This study investigates local expert perceptions of the role of environmental factors, especially in terms of contemporary climate change, in population movements from Bangladesh to India. The aim is to delve into locally held understandings of the phenomenon and to gain a better understanding of these migration processes, which are actively intertwined with local experiences. Both Indian and Bangladeshi experts were interviewed using semi-structured, in-depth interviews in order to explore insights from locally held perceptions and understandings of contextual factors. In total, 10 Bangladeshi and 15 Indian experts were interviewed, covering different disciplines, sectors, regions and job …
Effect of different solutions in reversing the damage caused by radiotherapy in dentin structure
2020
Background Previous studies have shown that radiotherapy of the head and neck region can cause direct changes in dental structure. This study evaluated the effect of different solutions on the dentin chemical composition and collagen structure of irradiated dentin. Material and Methods Sixty maxillary canines were distributed in 2 groups (n=30): non-irradiated and irradiated (radiotherapy: X-rays of 6 MV in 30 cycles of 2 Gy to 60 Gy). The teeth were sectioned, sanded, and polished to obtain 3x3x2 mm fragments, which were redistributed in 3 subgroups (n=10) according to the treatment employed: chlorhexidine 2% (CL), chitosan 0.2% (QT), and 0.5 M carbodiimide (EDC). The samples were analyzed…
Transferability of PCR-based diagnostic protocols: An international collaborative case study assessing protocols targeting the quarantine pine pathog…
2019
Producción Científica
Maternal and fetal genetic contribution to gestational weight gain
2018
Background: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG. Participants and methods: A genome-wide association study was used to identify maternal and fetal variants contributing to GWG in up to 10 543 mothers and 16 317 offspri…
Preclinical models for precision oncology
2018
Precision medicine approaches have revolutionized oncology. Personalized treatments require not only identification of the driving molecular alterations, but also development of targeted therapies and diagnostic tests to identify the appropriate patient populations for clinical trials and subsequent therapeutic implementation. Preclinical in vitro and in vivo models are widely used to predict efficacy of newly developed treatments. Here we discuss whether, and to what extent, preclinical models including cell lines, organoids and tumorgrafts recapitulate key features of human tumors. The potential of preclinical models to anticipate treatment efficacy and clinical benefit is also presented,…
The Functional Crosstalk between Myeloid-Derived Suppressor Cells and Regulatory T Cells within the Immunosuppressive Tumor Microenvironment
2021
Simple Summary Immunotherapy improved the therapeutic landscape for patients with advanced cancer diseases. However, many patients do not benefit from immunotherapy. The bidirectional crosstalk between myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) contributes to immune evasion, limiting the success of immunotherapy by checkpoint inhibitors. This review aims to outline the current knowledge of the role and the immunosuppressive properties of MDSC and Treg within the tumor microenvironment (TME). Furthermore, we will discuss the importance of the functional crosstalk between MDSC and Treg for immunosuppression, issuing particularly the role of cell adhesion molecules. …