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showing 10 items of 404 documents
Light Dark Matter Search with Ionization Signals in XENON1T
2019
We report constraints on light dark matter (DM) models using ionization signals in the XENON1T experiment. We mitigate backgrounds with strong event selections, rather than requiring a scintillation signal, leaving an effective exposure of (22±3) tonne day. Above ∼0.4 keVee, we observe <1 event/(tonne day keVee), which is more than 1000 times lower than in similar searches with other detectors. Despite observing a higher rate at lower energies, no DM or CEvNS detection may be claimed because we cannot model all of our backgrounds. We thus exclude new regions in the parameter spaces for DM-nucleus scattering for DM masses mχ within 3–6 GeV/c2, DM-electron scattering for mχ>30 MeV/c2, a…
The Attributive/Referential Distinction, Pragmatics, Modularity of Mind and Modularization
2011
In this paper I deal with the attributive/referential distinction. After reviewing the literature on the issue, I adopt Jaszczolt's view based on default semantics. I relate her view to Sperber and Wilson's Principle of Relevance. I argue in favour of the modularity hypothesis in connection with pragmatic interpretations. I also discuss the issue of modularization a la Karmiloff-Smith in connection with default inferences and, in particular, referential readings of NPs. I reply to some considerations by Cummings and use data from referential/attributive uses of NPs to show that the modularity hypothesis is defensible.
How an idea germinates into a projext or the intransitive resultative construction with Entity-Specific change-of-state verbs
2014
[EN] This study discusses how seven of Levin’s (1993) entity-specific change-of-state verbs (i.e. bloom, blossom, flower, germinate, sprout, swell, and blister) are subsumed into the intransitive resultative construction by highlighting and making use of the external and internal constraints proposed by the Lexical Constructional Model (LCM; Ruiz de Mendoza and Mairal 2007). External constraints refer to cognitive mechanisms such as high-level metaphor and/or metonymy whereas internal constraints are concerned with the encyclopedic and event structure makeup of verbs. The Internal Variable Conditioning constraint is at work when the information encapsulated by a predicate determines the cho…
Oppimiskontekstin vaikutus oppijanpragmatiikkaan : astemääritteet leksikaalisina nallekarhuina
2015
Artikkelissa käsitellään oppimisympäristön vaikutusta astemääritteiden käyttöön. Astemääritteet ovat jonkin ominaisuuden asteen suurta, kohtalaista tai vähäistä määrää ilmaisevia, pragmaattista merkitystä kantavia adverbeja (esim. melko, hyvin, tosi). Oppimisympäristön vaikutusta käsitellään artikkelissa korpusten avulla. Vaikka tällä hetkellä käytössä olevat oppijansuomen aineistot eivät ole täysin vertailukelpoisia keskenään esimerkiksi tekstien tehtävänantojen suhteen, voidaan niiden avulla tehdä alustavia havaintoja oppimiskontekstin vaikutuksesta ja edelleen hypoteeseja tulevia tutkimuksia varten. Oppimiskontekstilla tarkoitetaan tässä tutkimuksessa sitä ympäristöä, jossa kieltä opitaa…
Congenital emphysematous lung disease associated with a novel Filamin A mutation. Case report and literature review
2019
Abstract Background Progressive lung involvement in Filamin A (FLNA)-related cerebral periventricular nodular heterotopia (PVNH) has been reported in a limited number of cases. Case presentation We report a new pathogenic FLNA gene variant (c.7391_7403del; p.Val2464Alafs*5) in a male infant who developed progressive lung disease with emphysematous lesions and interstitial involvement. Following lobar resection, chronic respiratory failure ensued necessitating continuous mechanical ventilation and tracheostomy. Cerebral periventricular nodular heterotopia was also present. Conclusions We report a novel variant of the FLNA gene, associated with a severe lung disorder and PNVH. The lung disord…
Telomere Length in Circulating Leukocytes is Associated with Lung Function and Disease
2014
Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and s…
Genome-wide associations for birth weight and correlations with adult disease
2016
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. These life-course associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10(-8)). Overall, approximately 15% of variance in BW was captured by assays of fetal genetic variation. Using genet…
Multiclass HCV resistance to direct-acting antiviral failure in real-life patients advocates for tailored second-line therapies
2017
Background & Aims: Despite the excellent efficacy of direct-acting antivirals (DAA) reported in clinical trials, virological failures can occur, often associated with the development of resistance-associated substitutions (RASs). This study aimed to characterize the presence of clinically relevant RASs to all classes in real-life DAA failures. Methods: Of the 200 virological failures that were analyzed in 197 DAA-treated patients, 89 with pegylated-interferon+ribavirin (PegIFN+RBV) and 111 without (HCV-1a/1b/1g/2/3/4=58/83/1/6/24/25; 56.8% treatment experienced; 65.5% cirrhotic) were observed. Sanger sequencing of NS3/NS5A/NS5B was performed by home-made protocols, at failure (N= 200) and w…
No association between the cystatin C gene polymorphism and Alzheimer's disease: a case-control study in an Italian population.
2005
Cystatin C is an amyloidogenic protein found together with beta-amyloid in cerebral arteriolar walls of both patients with Alzheimer's Disease (AD) and conghopilic amyloid angiopathy. Several findings implicate cystatin C in the pathogenesis of vascular diseases. Recent genetic association studies proposed cystatin C gene (CST3) as a susceptibility factor for AD, although other reports did not replicate this finding. We conducted a case-control study including 192 probable AD cases and 192 age- and sex-matched controls to test the association between CST3 and AD. Possible interaction between CST3 and age at onset of AD or apolipoprotein E (APOE) was also examined. No significant differences…
The potential link between episodes of diverticulitis or hemorrhoidal proctitis and diets with selected plant foods : a case-control study
2021
Diverticulitis and hemorrhoidal proctitis in the population are significant public health problems. We studied the potential association between the intake of certain plant foods and diverticulitis or hemorrhoidal episodes through a case–control study including 410 cases and 401 controls. We used a semiquantitative food frequency questionnaire. The intake was additionally quantified according to a 24 h recall. The plant foods or derived food products were categorized by their main chemical components into ethanol, caffeine/theine/theobromine, capsaicin, alliin, acids, eugenol, and miscellaneous foods such as curcumin. The mean score for overall intake of plant foods under consideration was …