Search results for "Keywords"

Cardiovascular complications in COVID-19:A systematic review and meta-analysis

2020

Drug Resistance in Salmonella enterica ser. Typhimurium Bloodstream Infection, Malawi

2014

To the Editor: Salmonella enterica serotype Typhimurium is one of the most common causes of bloodstream infection in sub-Saharan Africa (1). Among adults, the principal risk factor for invasive nontyphoidal Salmonella (iNTS) disease is advanced HIV infection; up to 44% of HIV-infected patients experience bacteremic recurrence through recrudescence of the original infection (2,3). Epidemics of iNTS disease in sub-Saharan Africa have been associated with a novel genotype of S. enterica ser. Typhimurium of multilocus sequence type (ST) 313 that is rarely seen outside the region and is associated with multidrug resistance (MDR) to chloramphenicol, cotrimoxazole, and ampicillin (4,5). As a conse…

Surgical Antimicrobial Prophylaxis in Pediatric Patients Undergoing Plastic Surgery: A RAND/UCLA Appropriateness Method Consensus Study

2022

For many years, it was clearly shown that surgical procedures might be associated with surgical site infection (SSI). Many scientific institutions prepared guidelines to use in surgery to reduce abuse and misuse of antibiotics. However, in the general guidelines for surgical antibiotic prophylaxis, plastic surgical procedures are not addressed or are only marginally discussed, and children were almost systematically excluded. The main aim of this Consensus document is to provide clinicians with recommendations on antimicrobial prophylaxis for pediatric patients undergoing plastic surgery. The following scenarios were considered: clean plastic surgery in elective procedures with an exclusive…

Ontology-based cooperation of information systems : contributions to database-to-ontology mapping and XML-to-ontology mapping

2010

This thesis treats the area of ontology-based cooperation of information systems. We propose a global architecture called OWSCIS that is based on ontologies and web-services for the cooperation of distributed heterogeneous information systems. In this thesis, we focus on the problem of connecting the local information sources to the local ontologies within OWSCIS architecture. This problem is articulated by three main axes: 1) the creation of the local ontology from the local information sources, 2) the mapping of local information sources to an existing local ontology, and 3) the translation of queries over the local ontologies into queries over local information sources.

Carthage's military installations of the First Punic War on Monte Pellegrino (Palermo)

2019

The excavation in the park of Villa Belmonte (Monte Pellegrino, Palermo) has brought to light several warehouses, made with a “pseudo-frame” technique, probably with a straw roof, used for the storage of foodstuffs, given the large quantity of Punic-type amphorae found in situ, datable to around the middle of the third century BC. In addition, a section of road - about 3 m wide that proceeds in the direction of WNW- ESE, consisting of two layers of use - has been intercepted. We believe to have tracked down part of a strategic/military station used by the Carthaginian army during the crucial years of the First Punic War.

Spatial coherence and potential predictability of intraseasonal descriptors of the rainy season in Soudano-Sahelian Africa : application to the pearl…

2010

The aim of this thesis is twofold : (i) fill a lack of knowledge about the spatial coherence and seasonal predictability of the intraseasonal characteristics (ISC) of the soudano-sahelian rainy season. These ISC are the seasonal rainfall amount (S), the daily rainfall frequency > 1 mm (O), the daily rainfall mean intensity (I), the dates of the onset and withdrawal of the rainy season, the mean length of the dry (LDS) and/or wet spells (LWS) ; (ii) document the climate-agriculture relationship over the Niamey area based on the millet crop example.From FRIEND-AOC daily rainfall records (1950-2000) for a 136 stations-network located in Senegal, Mali, Burkina-Faso and Niger, the spatial cohere…

Eresus kollari (Araneae: Eresidae) calls for heathland management

2011

Northwest Europe’s largest heather-dominated sandy habitats are located in the nature reserve Lu¨neburgerHeide, Germany. Yet, even these appear to be losing their ability to support some of their stenotopic species such as theladybird spider, Eresus kollari Rossi 1846, and are thus becoming increasingly important for the preservation of thesespecies. The habitat requirements of this endangered spider species were investigated in order to obtain data that will helpstabilize the last remnants of the species’ population in northwest Germany. Several heathland habitats were surveyed bypitfall trapping during the mate-search period of the males. Two statistical methods were applied: logistic reg…

Comparison of HapMap and 1000 genomes reference panels in a large-scale genome-wide association study

2017

An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when compared to HapMap imputation. In order to assess the improvement of 1000G over HapMap imputation in identifying associated loci, we compared the results of GWA studies of circulating fibrinogen based on the two reference panels. Using both HapMap and 1000G imputation we performed a meta-analysis of 22 studies comprising the same 91,953 individuals. We identified six additional signals using 1000G imputation, while 29 loci were ass…

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

2018

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generat…

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

2011

Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene–environment interactions for circulating lipids has been reported. We screened for variants that modify the relationship between known epidemiological risk factors and circulating lipid levels in a meta-analysis of genome-wide association (GWA) data from 18 population-based cohorts with European ancestry (maximum N = 32,225). We collected 8 further cohorts (N = 17,102) for replication, and rs6448771 on 4p15 demonstrated genome-wide significant interaction with waist-to-hip-ratio (WHR) on …