Search results for "L3"
showing 10 items of 80 documents
Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans
2013
Brotherton, Paul et al.-- The Genographic Consortium
Meta-Analysis of Mitochondrial DNA Reveals Several Population Bottlenecks during Worldwide Migrations of Cattle
2014
Several studies have investigated the differentiation of mitochondrial DNA in Eurasian, African and American cattle as well as archaeological bovine material. A global survey of these studies shows that haplogroup distributions are more stable in time than in space. All major migrations of cattle have shifted the haplogroup distributions considerably with a reduction of the number of haplogroups and/or an expansion of haplotypes that are rare or absent in the ancestral populations. The most extreme case is the almost exclusive colonization of Africa by the T1 haplogroup, which is rare in Southwest Asian cattle. In contrast, ancient samples invariably show continuity with present-day cattle …
Esosomi ingegnerizzati per il trattamento della leucemia mieloide cronica
2016
La presente invenzione si riferisce al settore delle biotecnologie e più in particolare a quello dell’ingegneria genetica in quanto fornisce vescicole esosomiali ingegnerizzate affinché esprimano una specifica proteina di fusione che li rende adatti come veicolanti, sito e cellula specifici, di principi attivi nei confronti delle cellule il cui processo proliferativo risulta alterato e che sono coinvolte nella patogenesi della leucemia mieloide cronica.
Rationally integrable vector fields and rational additive group actions
2016
International audience; We characterize rational actions of the additive group on algebraic varieties defined over a field of characteristic zero in terms of a suitable integrability property of their associated velocity vector fields. This extends the classical correspondence between regular actions of the additive group on affine algebraic varieties and the so-called locally nilpotent derivations of their coordinate rings. Our results lead in particular to a complete characterization of regular additive group actions on semi-affine varieties in terms of their associated vector fields. Among other applications, we review properties of the rational counterpart of the Makar-Limanov invariant…
Multilingual Students´ Self-reported Use of their Language Repertoires when Writing in English
2015
Recent research suggests that multilingual students tend to use their complete language repertoires, particularly their L1, when writing in a non-native language (e.g. Cenoz & Gorter 2011; Wang 2003). While there is some international research on the L2 and L3 writing process among bilinguals, the L2/L3 writing process of bilingual and multilingual individuals in the Swedish context remains unexplored (Tholin 2012). This study, carried out in a Swedish secondary school, focuses on 131 bi- and multilingual students’ (age 15-16) self-reported languages of thought while writing an essay in English, which is a non-native language. Drawing on the translanguaging framework (Blackledge & Creese 20…
The J-invariant, Tits algebras and Triality
2012
In the present paper we set up a connection between the indices of the Tits algebras of a simple linear algebraic group $G$ and the degree one parameters of its motivic $J$-invariant. Our main technical tool are the second Chern class map and Grothendieck's $\gamma$-filtration. As an application we recover some known results on the $J$-invariant of quadratic forms of small dimension; we describe all possible values of the $J$-invariant of an algebra with orthogonal involution up to degree 8 and give explicit examples; we establish several relations between the $J$-invariant of an algebra $A$ with orthogonal involution and the $J$-invariant of the corresponding quadratic form over the functi…
The landscape of epilepsy-related GATOR1 variants
2019
Purpose:\ud \ud To define the phenotypic and mutational spectrum of epilepsies related to DEPDC5, NPRL2 and NPRL3 genes encoding the GATOR1 complex, a negative regulator of the mTORC1 pathway.\ud \ud Methods:\ud \ud We analyzed clinical and genetic data of 73 novel probands (familial and sporadic) with epilepsy-related variants in GATOR1-encoding genes and proposed new guidelines for clinical interpretation of GATOR1 variants.\ud \ud Results:\ud \ud The GATOR1 seizure phenotype consisted mostly in focal seizures (e.g., hypermotor or frontal lobe seizures in 50%), with a mean age at onset of 4.4 years, often sleep-related and drug-resistant (54%), and associated with focal cortical dysplasia…
Interleukin-36α axis is modulated in patients with primary Sjögren's syndrome.
2015
Summary The aim of this study was to investigate the expression of the interleukin (IL)-36 axis in patients with primary Sjögren's syndrome (pSS). Blood and minor labial salivary glands (MSG) biopsies were obtained from 35 pSS and 20 non-Sjögren's syndrome patients (nSS) patients. Serum IL-36α was assayed by enzyme-linked immunosorbent assay (ELISA). IL-36α, IL-36R, IL-36RA, IL-38, IL-22, IL-17, IL-23p19 and expression in MSGs was assessed by reverse transcription–polymerase chain reaction (RT–PCR), and tissue IL-36α and IL-38 expression was also investigated by immunohistochemistry (IHC). αβ and γδ T cells and CD68+ cells isolated from MSGs were also studied by flow cytometry and confocal …
CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration.
2007
Objective—Angiotensin II (Ang-II) and mononuclear leukocytes are involved in atherosclerosis. This study reports the inhibition of Ang-II–induced mononuclear cell recruitment by CXCR2 antagonism and the mechanisms involved.Methods and Results—Ang-II (1 nmol/L, i.p. in rats) induced CXC and CC chemokines, followed by neutrophil and mononuclear cell recruitment. Administration of the CXCR2 antagonist, SB-517785-M, inhibited the infiltration of both neutrophils (98%) and mononuclear cells (60%). SB-517785-M had no effect on the increase in CXC chemokine levels but reduced MCP-1, RANTES, and MIP-1α release by 66%, 63%, and 80%, respectively. Intravital microscopy showed that pretreatment with S…
Market valuation and acquiring firm performance in the short and long term: Out-of-sample evidence from Spain
2019
We investigate bidder’s short- and long-term performance in periods of high and low valuation market in response to announcements of acquisitions carried out by Spanish listed firms over the period 1991–2016. We find that acquirers of unlisted targets fully react at the announcement date in high valuation periods, meanwhile the underreaction of listed target bidders at the moment of the announcement in low valuation markets is the result of return continuations. In addition, we find that the market reaction do not depend on recent merger history. Therefore, we provide evidence that bidder reaction to acquisitions is not consistent with the predictions of market sentiment (optimism) after c…