Search results for "LAB"
showing 10 items of 7932 documents
A Bayesian unified framework for risk estimation and cluster identification in small area health data analysis.
2020
Many statistical models have been proposed to analyse small area disease data with the aim of describing spatial variation in disease risk. In this paper, we propose a Bayesian hierarchical model that simultaneously allows for risk estimation and cluster identification. Our model formulation assumes that there is an unknown number of risk classes and small areas are assigned to a risk class by means of independent allocation variables. Therefore, areas within each cluster are assumed to share a common risk but they may be geographically separated. The posterior distribution of the parameter representing the number of risk classes is estimated using a novel procedure that combines its prior …
IntentStreams
2015
The user's understanding of information needs and the information available in the data collection can evolve during an exploratory search session. Search systems tailored for well-defined narrow search tasks may be suboptimal for exploratory search where the user can sequentially refine the expressions of her information needs and explore alternative search directions. A major challenge for exploratory search systems design is how to support such behavior and expose the user to relevant yet novel information that can be difficult to discover by using conventional query formulation techniques. We introduce IntentStreams, a system for exploratory search that provides interactive query refine…
GROMEX: A Scalable and Versatile Fast Multipole Method for Biomolecular Simulation
2020
Atomistic simulations of large biomolecular systems with chemical variability such as constant pH dynamic protonation offer multiple challenges in high performance computing. One of them is the correct treatment of the involved electrostatics in an efficient and highly scalable way. Here we review and assess two of the main building blocks that will permit such simulations: (1) An electrostatics library based on the Fast Multipole Method (FMM) that treats local alternative charge distributions with minimal overhead, and (2) A $λ$-dynamics module working in tandem with the FMM that enables various types of chemical transitions during the simulation. Our $λ$-dynamics and FMM implementations d…
Modelling and Control of a 2-DOF Robot Arm with Elastic Joints for Safe Human-Robot Interaction
2021
Collaborative robots (or cobots) are robots that can safely work together or interact with humans in a common space. They gradually become noticeable nowadays. Compliant actuators are very relevant for the design of cobots. This type of actuation scheme mitigates the damage caused by unexpected collision. Therefore, elastic joints are considered to outperform rigid joints when operating in a dynamic environment. However, most of the available elastic robots are relatively costly or difficult to construct. To give researchers a solution that is inexpensive, easily customisable, and fast to fabricate, a newly-designed low-cost, and open-source design of an elastic joint is presented in this w…
Semi-automatic Brain Lesion Segmentation in Gamma Knife Treatments Using an Unsupervised Fuzzy C-Means Clustering Technique
2016
MR Imaging is being increasingly used in radiation treatment planning as well as for staging and assessing tumor response. Leksell Gamma Knife (R) is a device for stereotactic neuro-radiosurgery to deal with inaccessible or insufficiently treated lesions with traditional surgery or radiotherapy. The target to be treated with radiation beams is currently contoured through slice-by-slice manual segmentation on MR images. This procedure is time consuming and operator-dependent. Segmentation result repeatability may be ensured only by using automatic/semi-automatic methods with the clinicians supporting the planning phase. In this paper a semi-automatic segmentation method, based on an unsuperv…
ADME Prediction with KNIME: Development and Validation of a Publicly Available Workflow for the Prediction of Human Oral Bioavailability.
2020
In silico prediction of human oral bioavailability is a relevant tool for the selection of potential drug candidates and for the rejection of those molecules with less probability of success during the early stages of drug discovery and development. However, the high variability and complexity of oral bioavailability and the limited experimental data in the public domain have mainly restricted the development of reliable in silico models to predict this property from the chemical structure. In this study we present a KNIME automated workflow to predict human oral bioavailability of new drug and drug-like molecules based on five machine learning approaches combined into an ensemble model. Th…
Deep Learning-Based Methods for Prostate Segmentation in Magnetic Resonance Imaging
2021
Magnetic Resonance Imaging-based prostate segmentation is an essential task for adaptive radiotherapy and for radiomics studies whose purpose is to identify associations between imaging features and patient outcomes. Because manual delineation is a time-consuming task, we present three deep-learning (DL) approaches, namely UNet, efficient neural network (ENet), and efficient residual factorized convNet (ERFNet), whose aim is to tackle the fully-automated, real-time, and 3D delineation process of the prostate gland on T2-weighted MRI. While UNet is used in many biomedical image delineation applications, ENet and ERFNet are mainly applied in self-driving cars to compensate for limited hardwar…
Bias artifact suppression on MR volumes.
2007
RF-Inhomogeneity correction is a relevant research topic in the field of Magnetic Resonance Imaging (MRI). A volume corrupted by this artifact exhibits nonuni- form illumination both inside a single slice and between adjacent ones. In this work a bias correction technique is presented, which suppresses this artifact on MR vol- umes scanned from different body parts without any a-priori hypothesis on the artifact model. Theoretical foundations of the method are reported together with experimental results and a comparison is presented with both the 2D version of the algorithm and other techniques that are widely used in MRI literature.
A new Adaptive and Progressive Image Transmission Approach using Function Superpositions
2010
International audience; We present a novel approach to adaptive and progressive image transmission, based on the decomposition of an image into compositions and superpositions of monovariate functions. The monovariate functions are iteratively constructed and transmitted, one after the other, to progressively reconstruct the original image: the progressive transmission is performed directly in the 1D space of the monovariate functions and independently of any statistical properties of the image. Each monovariate function contains only a fraction of the pixels of the image. Each new transmitted monovariate function adds data to the previously transmitted monovariate functions. After each tra…
WSN Design and Verification Using On-Board Executable Specifications
2019
The gap between informal functional specifications and the resulting implementation in the chosen programming language is notably a source of errors in embedded systems design. In this paper, we discuss a methodology and a software platform aimed at coping with this issue in programming resource-constrained wireless sensor network nodes (WSNs). Whereas the typical development model for the WSNs is based on cross compilation, the proposed approach supports high-level symbolic coding of abstract models and distributed applications, as well as their test and their execution, directly on the target hardware. As a working example, we discuss the application of our methodology to specify the func…