Search results for "LAB"
showing 10 items of 7932 documents
Random Slicing: Efficient and Scalable Data Placement for Large-Scale Storage Systems
2014
The ever-growing amount of data requires highly scalable storage solutions. The most flexible approach is to use storage pools that can be expanded and scaled down by adding or removing storage devices. To make this approach usable, it is necessary to provide a solution to locate data items in such a dynamic environment. This article presents and evaluates the Random Slicing strategy, which incorporates lessons learned from table-based, rule-based, and pseudo-randomized hashing strategies and is able to provide a simple and efficient strategy that scales up to handle exascale data. Random Slicing keeps a small table with information about previous storage system insert and remove operations…
Pulsed EPR determination of water accessibility to spin-labeled amino acid residues in LHCIIb.
2009
Membrane proteins reside in a structured environment in which some of their residues are accessible to water, some are in contact with alkyl chains of lipid molecules, and some are buried in the protein. Water accessibility of residues may change during folding or function-related structural dynamics. Several techniques based on the combination of pulsed electron paramagnetic resonance (EPR) with site-directed spin labeling can be used to quantify such water accessibility. Accessibility parameters for different residues in major plant light-harvesting complex IIb are determined by electron spin echo envelope modulation spectroscopy in the presence of deuterated water, deuterium contrast in …
Modeling and Simulation of Network-on-Chip Systems with DEVS and DEUS
2013
Networks on-chip (NoCs) provide enhanced performance, scalability, modularity, and design productivity as compared with previous communication architectures for VLSI systems on-chip (SoCs), such as buses and dedicated signal wires. Since the NoC design space is very large and high dimensional, evaluation methodologies rely heavily on analytical modeling and simulation. Unfortunately, there is no standard modeling framework. In this paper we illustrate how to design and evaluate NoCs by integrating the Discrete Event System Specification (DEVS) modeling framework and the simulation environment called DEUS. The advantage of such an approach is that both DEVS and DEUS support modularity—the fo…
TOURISM POLICY IN LATVIA - FROM A TOP-DOWN TO A COLLABORATIVE APPROACH
2020
In 2019, Latvia drafted a National Development Plan [NDP 2027] for the next period, which also comprises actions for the development of the tourism sector. Unlike previous practices, approaches to drafting a common plan and developing and implementing tourism policy have changed significantly. The aim of the research is to describe the process of developing a tourism development plan, analyse the use of the latest planning and policy implementation approaches and evaluate the framework of the plan. A qualitative research strategy - a case study was used. The main research methods are document analysis, in-depth interviews and participatory observations. The process of drafting a new tourism…
Il ruolo dell'informazione contestuale e delle componenti sillabico-accentuali nella decodifica del testo scritto: un confronto tra dislessici evolut…
2010
L'esperimento qui presentato si propone di valutare l'importanza che assume, per un dislessico evolutivo rispetto ad un normolettore, la presenza di indizi che suggeriscano il significato del testo scritto (informazioni contestuali), nonché l'influenza di determinate caratteristiche sillabico-accentuali nelle prestazioni di lettura. Lo studio è stato condotto attraverso la somministrazione di frasi in ognuna delle quali è stata inserita una parola target secondo criteri relativi alla posizione (dislocazione a sinistra e dislocazione a destra) al fine di valutare l'influenza esercitata dall'informazione contestuale durante la decifrazione del testo. Le parole selezionate sono state accuratam…
Devianze sessuali
2021
La sessualità è una delle dimensioni umane che hanno ricevuto maggiori forme di controllo, regolamentazione e normalizzazione. In particolare, essa è divenuta argomento di studio tramite approcci essenzialisti riconducibili al concetto di scientia sexualis, che proponeva una sessualità monolitica, ancorata ai concetti di giusto e sbagliato, morale e immorale, normale e anormale. dipendentemente dalle culture e organizzazioni di riferimento. Ancora oggi, nonostante le riflessioni in chiave simbolico-interazionista offerta da autori quali Garfinkel, Goffman e Simon e Gagnon, la sessualità appare regolamentata dal discorso medico e legata a doppio nodo dalla dimensione morale. Anche le discipl…
Hybrid Chelator-Based PSMA Radiopharmaceuticals: Translational Approach
2021
(1) Background: Prostate-specific membrane antigen (PSMA) has been extensively studied in the last decade. It became a promising biological target in the diagnosis and therapy of PSMA-expressing cancer diseases. Although there are several radiolabeled PSMA inhibitors available, the search for new compounds with improved pharmacokinetic properties and simplified synthesis is still ongoing. In this study, we developed PSMA ligands with two different hybrid chelators and a modified linker. Both compounds have displayed a promising pharmacokinetic profile. (2) Methods: DATA5m.SA.KuE and AAZTA5.SA.KuE were synthesized. DATA5m.SA.KuE was labeled with gallium-68 and radiochemical yields of various…
In vivo comparison of DOTA based 68Ga-labelled bisphosphonates for bone imaging in non-tumour models.
2013
Bone metastases are a class of cancerous metastases that result from the invasion of a tumor into bone. The solid mass which forms inside the bone is often associated with a constant dull ache and severe spikes in pain, which greatly reduce the quality of life of the patient. Numerous (99m)Tc-labeled bisphosphonate functionalised complexes are well established tracers for bone metastases imaging. The objective of this research was to evaluate the pharmacokinetics and behaviour of three DOTA based bisphosphonate functionalised ligands (BPAMD, BPAPD and BPPED), using both (68)Ga μ-PET in vivo imaging and ex vivo biodistribution studies in healthy Wistar rats. The compounds were labelled with …
Taenia asiatica: the Most Neglected Human Taenia and the Possibility of Cysticercosis
2013
Not only Taenia solium and Taenia saginata, but also Taenia asiatica infects humans. The last species is not included in the evaluation of the specificity of the immunodiagnostic techniques for taeniasis/cysticercosis. There is currently no specific immunodiagnostic method for T. asiatica available. Therefore, due to the fact that molecular techniques (the only tool to distinguish the 3 Taenia species) are normally not employed in routine diagnostic methods, the 2 questions concerning T. asiatica (its definite geographic distribution and its ability to cause human cysticercosis), remain open, turning T. asiatica into the most neglected agent of human taeniasis-cysticercosis.
Chronic Diarrhea in a 5-Year-Old Girl: Pitfall in Routine Laboratory Testing with Potentially Severe Consequences
2009
A 5-year-old girl was referred because of recurrent watery diarrhea, abdominal pain, and flatulence. She was the second of 3 children. Her 10-year-old sister was normally developed and healthy. Her younger brother has meningomyelocele and hydrocephalus. At 1 year of age, the patient was admitted to the hospital for recurrent bronchitis, otitis media, food refusal, mild diarrhea, and abdominal distension since weaning. A sweat chloride analysis excluded cystic fibrosis. At that time, the patient’s laboratory results showed increased C-reactive protein (139 mg/L; reference interval, <5 mg/L) and moderate leukocytosis (14.6 × 109/L; reference interval, 4.5–13.5 × 109/L). Values for all other v…