Search results for "LAB"
showing 10 items of 7932 documents
The prevention of occupational risks todomestic workers and home carers in spain: The need to ratify ilo conventions 189 and 190
2021
La prevención de los riesgos laborales y de la violencia y acoso en el trabajo es una más de las asignaturas pendientes en el tratamiento y protección del trabajo doméstico y de cuidados en España. Las escasas referencias normativas, así como la ausencia de una decidida política preventiva en este sector, contrastan con las previsiones de dos Convenios de la OIT: el Convenio 189, sobre el trabajo decente para las trabajadoras y los trabajadores domésticos, del año 2011, y el Convenio 190, sobre la violencia y el acoso, de 2019, por lo que la anunciada ratificación de ambos exige una mirada crítica y un cambio hacia una auténtica perspectiva preventiva de los riesgos laborales de las trabaja…
Trafficking and labour exploitation in domestic work and the agricultural sector in Italy
2016
In Italy, as in many European countries, agriculture and domestic work are sectors characterised by high levels of irregular work without contract and with no respect of minimum pay, humane living conditions or access to basic services. Generalised informality however sometimes leads to cases of sever exploitation and outright human trafficking. This report focuses on the conditions that can lead from irregular work to abuse and trafficking in agriculture and domestic work – we question the cultural and economic aspects that make such situations possible. We also review the relevant legislation punishing exploiters and protecting victims with a view of identifying existing gaps and make sug…
Donalda Trampa valoda vietnē “Twitter”. Agresīvas valodas izmantošana prezidentūras laikā
2021
Bakalaura darbs “Donalda Trampa valoda vietnē “Twitter”. Agresīvas valodas izmantošana prezidentūras laikā.” Šī darba ietvaros tiek analizēti agresīvi Donalda Trampa ieraksti vietnē “Twitter”, lai noskaidrotu, vai tie ir vērsti pret jaunās labējās politikas pretiniekiem – medijiem un demokrātiem. Pētījuma mērķis ir noskaidrot Donalda Trampa valodas īpatnības, rakstot “Twitter”, un pētīt, kādu atslēgvārdu lietošana un pret ko vērstie agresīvie ieraksti visbiežāk ieskicē prezidenta agresiju un neapmierinātību. Pētījumā tiek noskaidrotas galēji labējās politikas vērtības, politiskā komunikācija un opozīcija, kas pētījuma gaitā tiek salīdzināta ar Donalda Trampa agresīviem ierakstiem “Twitter”.
CT-Arthrographie der Schulter nach operativer Versorgung ventraler Instabilitäten
1991
25 patients who had undergone a modified Lange repair were examined postoperatively after about four years, both clinically and by CT arthrography. Ventral redislocation was no longer seen postoperatively. As regards residual ventral instability, there was agreement between CT arthrography and the clinical findings in 20/25 patients (90%). Newly developed or residual dorsal instability could be accurately demonstrated by the presence of pathological changes of the dorsal labrum and by the observation of a wide dorsal joint recess. CT arthrography did not provide reliable evidence concerning loss of function and mobility of the treated shoulder. However, the presence of marked capsular foldi…
Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Codeine Phosphate
2014
The present monograph reviews data relevant to applying the biowaiver procedure for the approval of immediate-release multisource solid dosage forms containing codeine phosphate. Both biopharmaceutical and clinical data of codeine were assessed. Solubility studies revealed that codeine meets the "highly soluble" criteria according to World Health Organization (WHO), the European Medicines Agency (EMA), and the United States Food and Drug Administration (US FDA). Codeine's fraction of dose absorbed in humans was reported to be high (>90%) based on cumulative urinary excretion of drug and drug-related material following oral administration. The permeability of codeine was also assessed to be …
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Sitagliptin Phosphate Monohydrate
2021
Sitagliptin is an antihyperglycemic drug used in adults for the treatment of diabetes Type 2. Literature data and in-house experiments were applied in this monograph to assess whether methods based on the Biopharmaceutics Classification System (BCS) could be used to assess the bioequivalence of solid immediate-release (IR) oral dosage forms containing sitagliptin phosphate monohydrate, as an alternative to a pharmacokinetic study in human volunteers. The solubility and permeability characteristics of sitagliptin were reviewed according to the BCS, along with dissolution, therapeutic index, therapeutic applications, pharmacokinetics, pharmacodynamic characteristics, reports of bioequivalence…
Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Ketoprofen
2012
Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing ketoprofen are reviewed. Ketoprofen's solubility and permeability, its therapeutic use and therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions, and reported BE/bioavailability (BA)/dissolution data were taken into consideration. The available data suggest that according to the current Biopharmaceutics Classification System (BCS) and all current guidances, ketoprofen is a weak acid that would be assigned to BCS Class II. The extent of ketoprofen abso…
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Levetiracetam.
2015
Literature and experimental data relevant for the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing levetiracetam are reviewed. Data on solubility and permeability suggest that levetiracetam belongs to class I of the biopharmaceutical classification system (BCS). Levetiracetam's therapeutic use, its wide therapeutic index, and its favorable pharmacokinetic properties make levetiracetam a valid candidate for the BCS-based biowaiver approach. Further, no BE studies with levetiracetam IR formulations in which the test formulation failed to show BE with the comparator have been reported in the open lit…
In-Work Benefits for Married Couples: An Ex-Ante Evaluation of EITC and WTC Policies in Italy
2012
This paper investigates labor supply and redistributive effects of in-work benefits for Italian married couples using a tax-benefit microsimulation model and a multi-sectoral discrete choice model of labor supply. We consider in-work benefits based on the Earned Income Tax Credit (EITC) and the Working Tax Credit (WTC) existing in the US and the UK, respectively. The standard design of these income support mechanisms is however augmented with a premium for two-earner households to avoid potential disincentive effects on secondary earners. Revenue neutral policy simulations show that our reforms may greatly improve the current Italian tax-benefit system in terms of both incentive and redistr…
Comparison of heart rate monitoring with indirect calorimetry for energy expenditure evaluation
2012
Abstract Purpose The purpose of this study was to compare established methods with newly-developed methods for estimating the total energy expenditure (TEE). Methods The study subjects comprised 46 individuals, including 16 middle-aged men (mean age 51.4 years), 14 middle-aged women (mean age 49.9 years) and 16 young women (mean age 19.1 years). The TEE was estimated from 24-h heart rate (HR) data using newly-developed software (MoveSense HRAnalyzer 2011a, RC1, Suunto Oy, Vantaa, Finland), and was compared against the TEE determined using doubly labeled water (DLW). Agreement between the two methods was analyzed using Bland and Altman plots. Results The HR method yielded similar TEE values …