Search results for "LAB"
showing 10 items of 7932 documents
Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)
2020
According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored al…
Structure and function of the vacuolar Ccc1/VIT1 family of iron transporters and its regulation in fungi
2020
Iron is an essential micronutrient for most living beings since it participates as a redox active cofactor in many biological processes including cellular respiration, lipid biosynthesis, DNA replication and repair, and ribosome biogenesis and recycling. However, when present in excess, iron can participate in Fenton reactions and generate reactive oxygen species that damage cells at the level of proteins, lipids and nucleic acids. Organisms have developed different molecular strategies to protect themselves against the harmful effects of high concentrations of iron. In the case of fungi and plants, detoxification mainly occurs by importing cytosolic iron into the vacuole through the Ccc1/V…
Technical and health governance aspects of the External Quality Assessment Scheme for the SARS-CoV-2 molecular tests: institutional experience perfor…
2022
Abstract Objectives Since December 2019, the worldwide public health has been threatened by a severe acute respiratory syndrome caused by Coronavirus-2. From the beginning, a turning point has been the identification of new cases of infection, in order to minimize the virus spreading among the population. For this reason, it was necessary introducing a panel of tests able to identify positive cases, which became crucial for all countries. Methods As a Regional Reference Centre, the CRQ Laboratory (Regional Laboratory for the Quality Control) developed and conducted an External Quality Assessment (EQA) panel of assay, so as to evaluate the quality of real-time reverse transcription polymeras…
Du Zodiaque et des hommes. Temps, espace, éternité dans les édifices de culte entre le IV e et le XIII e siècle
2017
This dissertation deals with the iconography of the Zodiac between Antiquity and Middle Age, in particular in churches between the XIth and the XIIIth century. The heart of the dissertation is the analysis of a corpus of 260 items. These items concern the figuration of the signs of the Zodiac and the Labors of the months, whether or not combinated, within ecclesial ornamentation between the XIth and the XIIIth century. This period corresponds to the “renaissance” and to the growth of the figuration of the Zodiac in this context. The study is divided into three parts. The first section deals with historiography and with the presentation of the corpus. Then, the origins, re-appropriations and…
A Stigmergic Guiding System to Facilitate the Group Decision Process
2012
The paper presents a stigmergic approach to engineer a guiding system to facilitate the complex problem of designing the group decision processes. The system aims to provide contextual, actionable recommendations based on the knowledge and past experience of its users as recorded in a collaborative working environment implemented around the concept of stigmergic systems. Through an agent-based socio-simulation experiment we have demonstrated already the feasibility of this approach. The paper illustrates how the simulation results are transferred into a guiding system that facilitates the group decision process design through iterative queries reformulations for the identification, represen…
Oxygen consumption of F0 and F1 larval and juvenile European seabass Dicentrarchus labrax in resonse to ocean acidification and warming
2022
Ongoing climate change is leading to warmer and more acidic oceans. The future distribution of fish within the oceans depends on their capacity to adapt to these new environments. Only few studies have examined the effects of ocean acidification (OA) and warming (OW) on the metabolism of long-lived fish over successive generations. We therefore aimed to investigate the effect of OA on larval and juvenile growth and metabolism on two successive generations of European sea bass (Dicentrarchus labrax L.) as well as the effect of OAW on larval and juvenile growth and metabolism of the second generation. European sea bass is a large economically important fish species with a long generation time…
La configuración formal de las palabras idiomáticas originadas por acortamiento en locuciones en español: los casos de amén, estampía, mor y ton
2022
En el presente artículo pretendemos analizar la configuración formal con la que han quedado fijadas cuatro palabras idiomáticas (amén, estampía, mor y ton) que se han formado mediante aféresis, síncopa y apócope, es decir, procesos de acortamiento o eliminación de un fragmento respecto a una base originaria. Nos centraremos en fenómenos habituales que presentan este tipo de voces así formadas, como la estructura silábica, la acentuación paroxítona o la dislocación acentual respecto a sus bases. Reservamos para estudios futuros un análisis fraseológico centrado en los sintagmas y funciones de las cinco locuciones que estas conforman. The aim of this paper is to analyze the morphology of four…
Alma Mater: 2011/Ziema
2012
Centri storici manomessi: “antichi” come nuovi!
2012
The chapter presents the results of urban planning in Italy since 1950 and introduces the theories developed by Muratori and Caniggia for the restoration of historical centers. The paper critically shows some examples of typological restoration and introduces the debate that has developed around the outcomes of interventions.
Il collocamento dell’animale d’affezione nella crisi familiare: dalla “relazione” proprietaria alla responsabilità “padronale”
2022
The essay represents a reflection on the problem of assigning the pet in the case of separation or divorce. The author, after an analysis which took into consideration the multilevel legislation on the subject, which appears still incomplete, as well as the jurisprudence and the doctrine, elaborate a hermeneutical approach with the aim to allow the “custody” of the pet on the grounds of the protection of its well-being, with a prospect of a new category, called “responsabilità padronale”.