Search results for "LABOR"
showing 10 items of 3876 documents
Considerare i cittadini i primi alleati
2016
L’approvazione in molti Comuni italiani di «Regolamenti per l’amministrazione condivisa» sta dando luogo a molteplici «Patti» di collaborazione rispetto alla cura e rigenerazione dei beni comuni urbani. Si tratta di sperimentazioni in cui i diversi attori in gioco – Enti locali, abitanti, gruppi informali, soggetti privati e del privato sociale – provano a uscire da sterili polarizzazioni e a valorizzare le energie costruttive di tutti nel perseguire dei beni effettivamente comuni. Se è presto per fare il punto su processi ancora «giovani» (il primo Regolamento è del 2014), è tuttavia importante riflettere su come si stanno evolvendo le «regole del gioco» tra cittadini e amministrazioni loc…
Assessment of oxidative damage to proteins and DNA in urine of newborn infants by a validated UPLC-MS/MS approach
2014
The assessment of oxidative stress is highly relevant in clinical Perinatology as it is associated to adverse outcomes in newborn infants. This study summarizes results from the validation of an Ultra Performance Liquid Chromatography-tandem Mass Spectrometry (UPLC-MS/MS) method for the simultaneous quantification of the urinary concentrations of a set of endogenous biomarkers, capable to provide a valid snapshot of the oxidative stress status applicable in human clinical trials, especially in the field of Perinatology. The set of analytes included are phenylalanine (Phe), para-tyrosine (p-Tyr), ortho-tyrosine (o-Tyr), meta-tyrosine (m-Tyr), 3-NO2-tyrosine (3NO(2)-Tyr), 3-Cl-tyrosine (3Cl-T…
Data from: Parallel diversifications of Cremastosperma and Mosannona (Annonaceae), tropical rainforest trees tracking Neogene upheaval of South Ameri…
2017
Much of the immense present day biological diversity of Neotropical rainforests originated from the Miocene onwards, a period of geological and ecological upheaval in South America. We assess the impact of the Andean orogeny, drainage of lake Pebas, and closure of the Panama Isthmus on two clades of tropical trees (Cremastosperma, c. 31 spp.; and Mosannona, c. 14 spp.; both Annonaceae). Phylogenetic inference revealed similar patterns of geographically restricted clades and molecular dating showed diversifications in the different areas occurred in parallel, with timing consistent with Andean vicariance and Central American geodispersal. Ecological niche modelling approaches show phylogenet…
Mycotoxin contamination in laboratory rat feeds and their implications in animal research
2016
Compound feed is particularly vulnerable to multi-mycotoxin contamination. A method for the determination of 12 mycotoxins; enniatins A, A1, B, B1; aflatoxins B1, B2, G1, G2; OTA; ZEA; T-2 and HT-2 by liquid chromatography-tandem mass spectrometry has been developed and applied for the analysis of laboratory rat commercial feeds. The method trueness was checked by recovery assays at three different spiked levels (n = 9). Recoveries ranged from 73% to 112%, and the intra-day and inter-day precision were lower than 9% and 13%, respectively. Limits of quantitation were lower than 15 μg/kg. Twenty-seven laboratory rats feed samples showed multi-contamination by at least three up to six differen…
Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals
2011
Abstract Allergic contact dermatitis is induced by repeated skin contact with an allergen. Assessment of the skin sensitizing potential of chemicals, agrochemicals, and especially cosmetic ingredients is currently performed with the use of animals. Animal welfare and EU legislation demand animal-free alternatives reflected in a testing and marketing ban for cosmetic ingredients beginning in 2013. The underlying mechanisms of induction and elicitation of skin sensitization are complex and a chemical needs to comply several properties being skin sensitizing. To account for the multitude of events in the induction of skin sensitization an in vitro test system will consist of a battery of vario…
Human Hepatic Cell Cultures: In Vitro and In Vivo Drug Metabolism
2003
Drug metabolism is the major determinant of drug clearance, and the factor most frequently responsible for inter-individual differences in drug pharmacokinetics. The expression of drug metabolising enzymes shows significant interspecies differences, and variability among human individuals (polymorphic or inducible enzymes) makes the accurate prediction of the metabolism of a new compound in humans difficult. Several key issues need to be addressed at the early stages of drug development to improve drug candidate selection: a) how fast the compound will be metabolised; b) what metabolites will be formed (metabolic profile); c) which enzymes are involved and to what extent; and d) whether dr…
Diversity and Evolution of the Phenazine Biosynthesis Pathway
2010
ABSTRACT Phenazines are versatile secondary metabolites of bacterial origin that function in biological control of plant pathogens and contribute to the ecological fitness and pathogenicity of the producing strains. In this study, we employed a collection of 94 strains having various geographic, environmental, and clinical origins to study the distribution and evolution of phenazine genes in members of the genera Pseudomonas , Burkholderia , Pectobacterium , Brevibacterium , and Streptomyces . Our results confirmed the diversity of phenazine producers and revealed that most of them appear to be soil-dwelling and/or plant-associated species. Genome analyses and comparisons of phylogenies inf…
El análisis cuantitativo de trayectorias laborales. Un estado del arte
2022
La metodología cuantitativa aplicada al estudio de las trayectorias laborales ha experimentado un rápido auge que se ha extendido más allá del tradicional análisis de secuencias. El presente artículo es un estado del arte del desarrollo de nuevas técnicas estadísticas que pueden aplicarse o ya se aplican al estudio de trayectorias laborales. Además, incluimos sugerencias de software estadístico para la aplicación de cada una de las técnicas descritas. A lo largo de todo el texto, podrá observarse que la descripción de cada técnica se ha realizado desde un punto de vista conceptual, con el objetivo de llegar a un público amplio, que no necesite poseer una fuerte formación estadística. Es med…
Contributo para o estudo psicométrico da versão portuguesa do Cuestionario de Satisfacción Laboral S20/23
2010
Job satisfaction is understood through its dual role on organization productivity and employees achievement (Smith, 1998). The use of instruments to measure it in Portugal, has been the subject of several studies, such as the adaptation of the Cuestionario de Satisfacción Laboral S20/23 (Meliá & Peiró, 1989) to Portuguese population carried out by Pocinho and García (2008). This study is a further contribution to the study of the psychometric qualities of this instrument. The results on a sample of 136 Portuguese employees show that the questionnaire presents the adequate requirements of internal consistency (.95), test-retest reliability, and convergent validity (correlation of .84 with th…
Early results of a low-profile stent-graft for thoracic endovascular aortic repair
2020
Purpose To assess outcomes of a low-profile thoracic stent-graft in the treatment of thoracic aortic pathologies. Methods A retrospective analysis of all consecutive patients with aortic thoracic pathologies treated with the RelayPro device in two university hospitals between October 2018 and July 2019. Results 23 patients (65% men; mean age 63.4 ± 15 years) were treated. Pathologies included aortic dissections (n = 10), 5 residual type A (22%) and 5 type B (22%), 6 degenerative aortic aneurysms (26%), 4 penetrating aortic ulcers (17%), and aortic erosion, intramural hematoma and aortic rupture (n = 1 and 4% in each case). Two cases (9%) were emergent and two urgent. Proximal landing was a…