Search results for "LABOR"

THE RECOVERY-ELISA—A NOVEL ASSAY TECHNIQUE TO MONITOR THERAPY WITH HUMANIZED ANTIBODIES: THE EXAMPLE OF OMALIZUMAB

2013

The therapeutic use of antibodies has grown exponentially, providing new treatment options for various diseases. Monitoring treatment with therapeutic antibodies is a particular challenge because often the target antigen is no longer measurable or the results are unreliable. To overcome this problem, a recovery-ELISA was developed to quantify therapeutic antibody and antigen by a modification of the traditional sandwich immunoassay using omalizumab as an example. Standard serum samples were spiked with IgE and omalizumab in a certain concentration range to create standard curves. After incubation and washout procedures, the reaction was stopped and the plate read with bichromatic absorbance…

Intraoperative transfusion practices and perioperative outcome in the European elderly: A secondary analysis of the observational ETPOS study

2022

PLOS ONE 17(1), e0262110 (2022). doi:10.1371/journal.pone.0262110

Assessing the impact of copy number variants on miRNA genes in autism by Monte Carlo simulation.

2014

Autism Spectrum Disorders (ASDs) are childhood neurodevelopmental disorders with complex genetic origins. Previous studies have investigated the role of de novo Copy Number Variants (CNVs) and microRNAs as important but distinct etiological factors in ASD. We developed a novel computational procedure to assess the potential pathogenic role of microRNA genes overlapping de novo CNVs in ASD patients. Here we show that for chromosomes # 1, 2 and 22 the actual number of miRNA loci affected by de novo CNVs in patients was found significantly higher than that estimated by Monte Carlo simulation of random CNV events. Out of 24 miRNA genes over-represented in CNVs from these three chromosomes only …

Therapeutic Angiogenesis in Surgery and Oncology

1994

The aim of this presentation is to demonstrate the pathological importance of microenvironmental tissue hypoxia and to elucidate a general treatment concept for this situation which we have termed therapeutic angiogenesis 1. Hypoxia not only represents an insufficient oxygen supply for the cells of a given tissue area but is also regarded as an indicator for their metabolic deprivation and the concomitant accumulation of waste products. Therapeutic angiogenesis applied either with clinically established methods or using novel ways, which are the objectives of laboratory research and clinical trials at present, or in so far hypothetical forms, should lead to an expansion of the functional mi…

Crowdboard: An Augmented Whiteboard to Support Large-Scale Co-Design

2013

Co-design efforts attempt to account for many diverse viewpoints. However, design teams lack support for meaningful real-time interaction with a large community of potential stakeholders. We present Crowdboard, a novel whiteboard system that enables many potential stakeholders to provide real-time input during early-stage design activities, such as concept mapping. Local design teams develop ideas on a standard whiteboard, which is augmented with annotations and comments from online participants. The system makes it possible for design teams to solicit real-time opinions and ideas from a community of people intrinsically motivated to shape the product/service.

La investigación en el aula a través de las redes sociales: co-diseño de un blog como herramienta de innovación y mejora de la docencia.

2020

[ES] El nuevo Espacio Europeo de Educación ha supuesto la incorporación de nuevas metodologías y dinámicas digitales en entornos formales como el ámbito universitario, motivando al alumnado a involucrarse en sus procesos de aprendizaje colaborativo dentro del aula. A través de la asignatura Investigación en Sistemas de Bienestar Social del grado de Trabajo Social de la Universitat de València se ha llevado a cabo un proyecto de innovación docente, financiado por dicha universidad, con el objetivo de mejorar la docencia a través del uso de las redes sociales para la construcción e intercambio de conocimiento superior en materia de investigación. Concretamente, se ha co-diseñado junto al alum…

Querytogether : Enabling entity-centric exploration in multi-device collaborative search

2018

Collaborative and co-located information access is becoming increasingly common. However, fairly little attention has been devoted to the design of ubiquitous computing approaches for spontaneous exploration of large information spaces enabling co-located collaboration. We investigate whether an entity-based user interface provides a solution to support co-located search on heterogeneous devices. We present the design and implementation of QueryTogether, a multi-device collaborative search tool through which entities such as people, documents, and keywords can be used to compose queries that can be shared to a public screen or specific users with easy touch enabled interaction. We conducted…

Coagulation and fibrinolysis

2016

Prostitution voluntary or forced. A contribution to the debate

2011

La tesis abolicionista de que nadie puede elegir libremente vender su cuerpo ha sido cuestionada por quienes reclaman el reconocimiento de derechos laborales para los trabajadores del sexo, lo cual ha dado lugar a una encendida polémica sobre el carácter voluntario o forzado de la prostitución. Los testimonios de veintitrés mujeres (incluyendo cinco ex prostitutas), recogidos mediante entrevistas en profundidad, sugieren que todas ellas están situadas en un punto intermedio del continuum que va desde la coerción criminal hasta la opción vocacional. Los pasajes relativos específicamente al itinerario de acceso a este mundo permiten distinguir tres tipos de prostitución en función del grado d…

A cognitive architecture for artificial vision

1997

Abstract A new cognitive architecture for artificial vision is proposed. The architecture, aimed at an autonomous intelligent system, is cognitive in the sense that several cognitive hypotheses have been postulated as guidelines for its design. The first one is the existence of a conceptual representation level between the subsymbolic level, that processes sensory data, and the linguistic level, that describes scenes by means of a high level language. The conceptual level plays the role of the interpretation domain for the symbols at the linguistic levels. A second cognitive hypothesis concerns the active role of a focus of attention mechanism in the link between the conceptual and the ling…