Search results for "LAL"
showing 10 items of 1001 documents
Environment- and sequence-dependent modulation of the double-stranded to single-stranded conformational transition of gramicidin A in membranes.
1998
The role of the membrane lipid composition and the individual Trp residues in the conformational rearrangement of gramicidin A along the folding pathway to its channel conformation has been examined in phospholipid bilayers by means of previously described size-exclusion high-performance liquid chromatography HPLC-based strategy (Bano et al. (1991) Biochemistry 30, 886). It has been demonstrated that the chemical composition of the membrane influences the transition rate of the peptide rearrangement from double-stranded dimers to beta-helical monomers. The chemical modification of Trp residues, or its substitution by the more hydrophobic residues phenylalanine or naphthylalanine, stabilized…
Patología degenerativa del raquis cervical. Revisión
2020
Patología Degenerativa del Raquis Cervical. Revisión La enfermedad degenerativa cervical es frecuente, aunque casi siempre asintomática. Cuando se manifiesta, los síntomas pueden presentarse en forma de dolor cervical axial de radiculopatía o de mielopatía. La compresión crónica del raquis cervical debido a procesos degenerativos, incluyendo la hernia discal, espondilosis, y la hipertrofia ligamentosa o su osificación, ha sido en su conjunto atribuido como mielopatía cervical degenerativa (DCM).
Bioaccessibility and decomposition of cylindrospermopsin in vegetables matrices after the application of an in vitro digestion model.
2018
Research on the human exposure to Cylindrospermopsin (CYN) via consumption of contaminated food is of great interest for risk assessment purposes. The aim of this work is to evaluate for the first time the CYN bioaccessibility in contaminated vegetables (uncooked lettuce and spinach, and boiled spinach) after an in vitro digestion model, including the salivar, gastric and duodenal phases and, colonic fermentation under lactic acid bacteria. The results obtained showed that the digestion processes are able to diminish CYN levels, mainly in the colonic phase, especially in combination with the boiling treatment, decreasing CYN levels in a significant way. Moreover, the potential decomposition…
Hereditary familial polyposis and Gardner’s syndrome: Contribution of the odontostomatology examination in its diagnosis and a case description
2005
La poliposis adenomatosa familiar (PAF) y su variante fenotípica, el síndrome de Gardner, constituyen una infrecuente patología hereditaria autosómica dominante. Se caracterizan por el desarrollo, generalmente durante la segunda y tercera década de la vida, de múltiples pólipos adenomatosos en el colon y en el recto. Estos pólipos tienen un riesgo elevado de transformación maligna subsiguiente, cosa que suele ocurrir en las décadas tercera y cuarta de la vida. Las manifestaciones fenotípicas de la PAF pueden ser muy variadas. Así, además de los pólipos colorrectales, los individuos afectos pueden presentar manifestaciones extracolónicas, entre las que se destacan: pólipos gastroduodenales, …
Oppilaiden kaikupuheen tehtävät kielellisesti epäsymmetrisissä luokkahuonekeskusteluissa
2017
Repeating the words of the conversational partners gives the persons with restricted communicative abilities a possibility for taking an active part in and exerting some control in the conversational interaction. Earlier research has approached the repeats with two different viewpoints: they have been considered either as problematic and meaningless echolalia, or as motivated communication meaningful for speakers themselves. This paper examines the functions for which students with special needs use repetition in their interaction with teachers and the ways in which teachers treat these echolalic responses in classroom talk. The research data consists of the video-recordings of lessons in o…
Performing transnational family with the affordances of mobile apps : a case study of Polish mothers living in Finland
2020
Affordances provided by digital technologies and mobile apps (WhatsApp, Skype, Messenger) help in maintaining familyhood. These mobile apps enable the creation of in-app family groups. They also afford image sharing, which is used for phatic purposes. Digital connectivity provides the illusions of togetherness and belonging, and allows for performing family in a transnational context (emotional transnationalism). However, it also generates the feelings of guilt through infrequent communication. In the auto-driven visual elicitation interviews, the study looks at family constellations and technologically mediated communication from the perspective of five Polish mothers living in Finland. Ap…
Is measurement of the gingival biotype reliable? Agreement among different assessment methods.
2019
Background To determine agreement among the most commonly used methods for assessing the gingival biotype. Material and Methods An electronic survey was sent to a sample of dentists practicing in Spain. The questionnaire was based on the evaluation of 5 cases involving different gingival biotype assessment methods. Dentists were required to classify the cases as having a “thin”, “thick” or “not able to classify” biotype. Each case was assessed using a frontal intraoral photo of the anterior teeth; an enlarged photo of the buccal aspect of the tooth with a periodontal probe inserted inside the sulcus; and the real thickness measured in mm with a calibrated needle. Agreement among the classif…
Synthesis and characterization of vanadyl(IV) complexes of Schiff bases derived from anthranilic acid and salicylaldehyde (or its derivatives) or ace…
1997
Anhydrous, dimeric vanadyl(IV) complexes of Schiff bases derived from [1+1] condensation of salicylaldehyde (or its derivatives) and anthranilic acid, have been synthesized from CH3CN and were characterized by elemental analysis, FTIR, EPR, absorption, TGA, cyclic voltammetry and room temperature magnetic susceptibility measurements. These complexes were found to be oxidized by air in polar solvents like MeOH and DMF to V-V products. The E(1/2) values were found to be around 660 mV indicating that the carboxylate group favours vanadyl(IV) binding when compared to the alkoxo-bound vanadium complexes. Oxidative instability of these complexes are dependent on the substituent on the salicylalde…
Las guías de práctica clínica de manejo de la dislipemia. Una visión transatlántica.Clinical Practice Guidelines for the Management of Dyslipidemia. …
2015
Situación de la dislipemia en España. Las guías de práctica clínica (GPC) se han convertido en un instru- mento fundamental en nuestra actividad asistencial. La revisión deta- llada de la evidencia científica disponible permite la elaboración de documentos de recomendaciones diagnósticas y terapéuticas avala- dos por las principales instituciones científicas. A pesar de que habi- tualmente están basadas en los mismos estudios y, por lo tanto, se redactan a partir de los mismos resultados, pueden existir diferentes interpretaciones y distintos enfoques, como ha sucedido reciente- mente en las principales GPC que abordan el manejo de las dislipe- mias. En el año 2011 la Sociedad Europea de Ca…
Effects of SCA40 on human isolated bronchus and human polymorphonuclear leukocytes: comparison with rolipram, SKF94120 and levcromakalim
1996
1. SCA40 (0.1 nM-0.1 mM) produced concentration-dependent suppression of the spontaneous tone of human isolated bronchus (-log EC50 = 6.85 +/- 0.09; n = 10) and reached a maximal relaxation similar to that of theophylline (3 mM). The potency (-log EC50 values) of SCA40 compared to other relaxants was rolipram (7.44 +/- 0.12; n = 9) > SCA40 > or = levcromakalim (6.49 +/- 0.04; n = 6) > SKF94120 (5.87 +/- 0.10; n = 9). 2. When tested against the activity of the isoenzymes of cyclic nucleotide phosphodiesterase (PDE) isolated from human bronchus, SCA40 proved highly potent against PDE III (-log IC50 = 6.47 +/- 0.16; n = 4). It was markedly less potent against PDE IV (4.82 +/- 0.18; n = 4) and …