Search results for "LB"

showing 10 items of 5653 documents

Fixed Points for Multivalued Convex Contractions on Nadler Sense Types in a Geodesic Metric Space

2019

In 1969, based on the concept of the Hausdorff metric, Nadler Jr. introduced the notion of multivalued contractions. He demonstrated that, in a complete metric space, a multivalued contraction possesses a fixed point. Later on, Nadler&rsquo

<b>54H25</b>Physics and Astronomy (miscellaneous)GeodesicGeneral MathematicsMathematics::General TopologyFixed-point theorem02 engineering and technologyFixed point01 natural sciencesComplete metric spacegeodesic metric spaceCombinatoricsregular golbal-inf function0202 electrical engineering electronic engineering information engineeringComputer Science (miscellaneous)0101 mathematicsMathematicsStatistics::Applicationslcsh:Mathematics010102 general mathematicsRegular polygonconvex multivalued left A-contractionlcsh:QA1-939Metric spaceHausdorff distancefixed point<b>47H10</b>Chemistry (miscellaneous)<title>MSC</title>020201 artificial intelligence & image processingright A-contractionSymmetry
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Clinicopathological Significance of Syndecan-1 in Cholangiocarcinoma: A Study Based on Immunohistochemistry and Public Sequencing Data

2021

Background: Syndecan-1 (CD138

<i>SDC1</i>Pathologymedicine.medical_specialtyanimal structuresArticleSyndecan 1SDC103 medical and health sciences0302 clinical medicinemedicineLymph nodeIntrahepatic Cholangiocarcinoma030304 developmental biology0303 health sciencesbusiness.industryGallbladderRCancersyndecan-1General Medicinemedicine.diseasecarbohydrates (lipids)medicine.anatomical_structure030220 oncology & carcinogenesisBiliary Intraepithelial NeoplasiaMedicineImmunohistochemistrybiomarkerPancreasbusinesscholangiocarcinomaJournal of Clinical Medicine
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Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

ABCC1 ATP binding cassette subfamily C member 1IC50 half maximal inhibitory concentrationMultidrug resistancePharmacologyNADPH reduced nicotinamide adenine dinucleotide phosphateF bioavailabilitychemistry.chemical_compoundPCR polymerase chain reaction0302 clinical medicineMDR multidrug resistanceECL electrochemiluminescencet1/2 elimination half-lifeLC–MS liquid chromatography coupled with mass spectrometryN.D. not detectedGeneral Pharmacology Toxicology and PharmaceuticsBBB blood–brain barriermedia_commonATF3 activating transcription factor 30303 health sciencesChemistryABC ATP-binding cassetteNMPA National Medical Products AdministrationPXR pregnane X receptorSDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresisHBSS Hankʹs balanced salt solutionABCB1Combination chemotherapyProdrugMarsdenia tenacissimaCmax peak concentrationPaclitaxelGAPDH glyceraldehyde-3-phosphate dehydrogenase030220 oncology & carcinogenesisBHI brain heart infusionOriginal ArticleAUC0–∞ area under plasma concentration vs. time curveMRT mean residence timeDrugmedia_common.quotation_subjectRM1-950Vd volume of distributionABCB1 ATP binding cassette subfamily B member 1UIC-2 mouse monoclonal ABCB1 antibodyABCG2 ATP binding cassette subfamily G member 2Combination chemotherapyCYP cytochrome P450 isozymePI propidium iodideTEER transepithelial electrical resistance03 medical and health sciencesPBS phosphate buffer salineFBS fetal bovine serumDox doxorubicinIn vivoPOP polyoxypregnanemedicine030304 developmental biologyEVOM epithelial tissue voltohmmeterTmax time for peak concentrationCancerLBE lowest binding energyPE phycoerythrinmedicine.diseaseMultiple drug resistancePolyoxypregnanePapp apparent permeabilityN.A. not applicableCancer cellH&E hematoxylin and eosinMDR1a multidrug resistance protein 1aTherapeutics. PharmacologyqPCR quantitative PCRM. tenacissima Marsdenia tenacissimaCL clearanceSD standard derivationActa Pharmaceutica Sinica B
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Positive effects of an extracellular matrix hydrogel on rat anterior cruciate ligament fibroblast proliferation and collagen mRNA expression

2015

Summary Background/Objective We have previously shown that an extracellular matrix (ECM) bioscaffold derived from porcine small intestine submucosa (SIS) enhanced the healing of a gap injury of the medial collateral ligament as well as the central third defect of the patellar tendon. With the addition of a hydrogel form of SIS, we found that a transected goat anterior cruciate ligament (ACL) could also be healed. The result begs the research question of whether SIS hydrogel has positive effects on ACL fibroblasts (ACLFs) and thus facilitates ACL healing. Methods In the study, ECM-SIS hydrogel was fabricated from the digestion of decellularised and sterilised sheets of SIS derived from αGal-…

ACL fibroblasts; Fibre morphology; Growth factors; Hydrogel; Porcine small intestine submucosa; Orthopedics and Sports Medicinelcsh:Diseases of the musculoskeletal systemfibre morphologyAnterior cruciate ligamentExtracellular matrixchemistry.chemical_compoundgrowth factorsmedicineOrthopedics and Sports MedicineBovine serum albuminFibroblastporcine small intestine submucosabiologyCell growthAnatomyGrowth factorACL fibroblastsACL fibroblastMolecular biologymedicine.anatomical_structurechemistrySelf-healing hydrogelsbiology.proteinOriginal Articlelcsh:RC925-935hydrogelBromodeoxyuridineExplant cultureJournal of Orthopaedic Translation
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Lavtemperatur brenselceller

2005

Dokumentet er en del av en eksamensoppgave i MEF4200 Energimaterialer ved UiO høsten 2004. Som del av eksamen i emnet MEF4200 Energimaterialer ved Universitetet i Oslo (UiO) høsten 2004 var oppgaven å skrive en populærvitenskapelig artikkel for avgangselever i videregående skole. Artikkelen presenteres her og omhandler lavtemperatur brenselceller. De brenselcelletypene som beskrives er alkaliske brenselceller, PEM-brenselceller og metanolbrenselceller, alle med en driftstemperatur på normalt under 100 °C, og deres bruksområder.

AFCAlkaliske brenselcellerPEM-brenselcellerPEMFCMetanolbrenselcellerDMFCVDP::Matematikk og naturvitenskap: 400
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STRESS E SODDISFAZIONE LAVORATIVA DEL PERSONALE FRONTLINE NELLE ORGANIZZAZIONI ALBERGHIERE

2011

ALBERGHIERESettore M-PSI/06 - Psicologia Del Lavoro E Delle OrganizzazioniPERSONALE FRONTLINE
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ALBERTO CALZA BINI ARCHITETTO (1881-1957)

2011

ALBERTO CALZA BINIARCHITETTOSettore ICAR/18 - Storia Dell'Architettura
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Time-Varying mHAP-III Is the Most Accurate Predictor of Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization

2021

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; The prognosis of patients undergoing transarterial chemoembolization (TACE) is extremely variable, and a confounding factor is that TACE is often repeated several times. We retrospectively evaluated the accuracy of different prognostic scores and staging systems in estimating overall survival (OS) in patients with hepatocellular carcinoma (HCC). &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; An analysis considering prognostic models as time-varying variables was performed, calculating OS from the time of TACE to the time of the subsequent treatment. Total follow-up time for each patient was therefore split into several observation times ac…

ALBI grade; Barcelona Clinic Liver Cancer; Cancer of the Liver Italian Program; ITALICA staging system; MESIAHmedicine.medical_specialtylcsh:RC254-282GastroenterologyALBI gradeBarcelona Clinic Liver CancerInternal medicineMedicineIn patientCancer of the Liver Italian ProgramITALICA staging systemRadiologic ResponseSettore MED/12 - GastroenterologiaOriginal PaperHepatologybusiness.industryProportional hazards modelConfoundingHazard ratiolcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseaseMESIAHOncologyHepatocellular carcinomaAkaike information criterionbusinessLiver cancer
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Leon Battista Alberti archeologo

2007

Il Convegno rientra nelle celebrazioni ufficiali per il VI centenario della nascita del grande umanista del Quattrocento italiano. Il contributo, unico nel panorama della critica albertiana, mira a mettere a fuoco le propensioni antiquarie e archeologiche dell'Alberti, inquadrando questi interessi nel vasto panorama della cultura antiquaria del Quattrocento italiano. Ne rivela anche aspetti significativi nel suo concreto operare come architetto e ne ricostruisce le pratiche della ricerca sui monumenti antichi di Roma e di molte altre parti dell'Italia.

ANTIQUARIALEON BATTISTA ALBERTIARCHITETTURAUMANESIMOSTORIA DELL'ARCHEOLOGIASettore L-ANT/07 - Archeologia ClassicaLeon Battista Alberti storia dell'archeologia storia dell'architettura
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Flexibility in otherwise consistent non-breeding movements of a long-distance migratory seabird, the long-tailed skua

2017

Quantifying within- and between-individual variation in animal migration strategies is a first step towards our understanding of the ability of migrants to adjust to changes in the en - vironment. We studied consistency (or, conversely, flexibility) in movement patterns at large (>1000 km) to meso-scales (100−1000 km) during the non-breeding season of the long-tailed skua Stercorarius longicaudus, a long-distance migratory Arctic seabird, using light-based geolocation. We obtained 97 annual tracks of 38 individuals and quantified similarity between routes. Overall, tracks of the same individual were generally within about 200 to 300 km of their previous year’s route, and more similar than t…

ATLANTIC0106 biological sciencesEnvironmental changeIndividual consistency · Repeatability · Stercorarius longicaudus · Seabirds · Tracking · Non-breeding movements · Flexibility:Zoology and botany: 480 [VDP]CONSERVATIONMODELSTRANS-EQUATORIAL MIGRATIONAquatic Science010603 evolutionary biology01 natural sciencesSkuaStercorarius longicaudusOnderzoeksformatieOCEANALBATROSSESindividual consistencyDISPERSALbiology.animalRepeatability:Zoologiske og botaniske fag: 480 [VDP]Ecology Evolution Behavior and SystematicsEcologybiologyEcology[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]010604 marine biology & hydrobiologyFlexibility (personality)trackingbiology.organism_classificationTERNS STERNA-PARADISAEASeabirdsGeolocation[ SDV.BID.EVO ] Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]GeographyArcticWildlife Ecology and ConservationStercorarius longicaudusNAVIGATIONWIASnon-breeding movementsBiological dispersalSeabirdFlexibilityBEHAVIOR
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