Search results for "LB"
showing 10 items of 5653 documents
Lateral Ligament Reconstruction
2019
The lateral collateral ligament complex represents the primary lateral elbow ligament stabilizers. In cases of lateral elbow instability, surgical treatment is recommended. Repair should be anatomical and should restore stability to the elbow in order to permit an early active range of motion. Anatomic repair of soft tissue avulsions from bone can be performed with trans-osseous suture or suture anchors. Reconstruction may be required in severe cases and where primary repair is not possible. This chapter describes the surgical techniques for repair and reconstruction of the lateral collateral ligament of the elbow.
Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis
2007
Abstract The transcription factor STAT4 mediates signals of various proinflammatory cytokines, such as IL-12, IL-15, and IL-23, that initiate and stabilize Th1 cytokine production. Although Th1 cytokine production has been suggested to play a major pathogenic role in rheumatoid arthritis, the role of STAT4 in this disease is poorly understood. In this study, we demonstrate a key functional role of STAT4 in murine collagen-induced arthritis (CIA). In initial studies we found that STAT4 expression is strongly induced in CD4+ T cells and to a lesser extent in CD11b+ APCs during CIA. To analyze the role of STAT4 for arthritis manifestation, we next investigated the outcome of interfering with S…
Fertility in McCune Albright syndrome female: A case study focusing on AMH as a marker of ovarian dysfunction and a literature review.
2021
Abstract Background The molecular basis of McCune Albright syndrome (MAS) is a recurrent GNAS Postzygotic gain of function sporadic mutation, resulting in a mosaic disease. Most of girls present precocious puberty, caused by the development of recurrent ovarian cysts with autonomous Hyperestrogenic stimulation. After menarche, the majority of patients with ovarian GNAS mutation have menstrual disturbances and infertility. Objectives We wanted to focus on the fertility of MAS females and propose an appropriate management, by a detailed case report and an exhaustive review of the literature on fertility and pregnancy in MAS females. Results We present the case of a 29-year-old MAS female, who…
Acute (0-2h) and delayed (2-8D) effects of exercise-induced muscle damage and soreness on elbow target movements.
2011
The aim was to examine the acute and delayed effects of exercise-induced muscle damage and soreness on elbow target movements (TM) performance and control. Ten males performed an exercise of 50 maximal eccentric elbow actions. TMs were performed at three movement ranges. Maximal forces, active stretch reflex and TM were tested, and muscle soreness, creatine kinase and elbow joint stiffness were determined acute (after and 2 h) and delayed (2, 4, 6, 8d) postexercise. Both the long lasting muscle soreness and force drop were observed after the exercise. Joint stiffness was increased at 2 h postexercise. The highest deterioration in flexion-TM performance was found at the time (2 h) and at the…
Maxillary bone lesions in McCune-Albright syndrome:a case report
2011
Abstract Objectives In this study, we report on the clinical maxillary manifestations of a patient affected by McCune-Albright syndrome and the implications for orthodontic therapy. Materials and methods A male, 8-year-old patient was examined at the Department of Orthodontics of the University of L’Aquila for a problem of anterior open-bite. In the clinical examination, a small swelling of the left hemi-maxilla was seen in the area corresponding to the root apex of 16 and under the tooth buds of 14 and 15. In a panoramic radiograph, a radio-opaque area was detected in this zone. From the computer tomography examination, a bone lesion was identified. Results Identification of this bone lesi…
Radial Head Fractures
2014
Radial head fractures are the most common elbow fractures, accounting for 20–30 %. Typically, the fractures evolve from a fall on the outstretched hand with the elbow extended and the forearm in pronation. The role of the radial head as an important stabilizer of the elbow joint has been recognized in the last decade. Sixty percent of the axial load transmitted through the elbow is conducted through the radial head. Furthermore, the radial head is an important stabilizer against valgus stresses. While the medial collateral ligament (MCL) is the primary stabilizer against valgus stress, the role of the radial head emerges when the MCL is torn. These findings have led to a change in treatment…
Biomechanical Analysis of a New Elbow Prosthesis
2019
Total elbow arthroplasty (TEA) is an effective and frequently used treatment for patients with debilitating elbow pathology. Total elbow prostheses have lagged behind those of the knee, hip and shoulder for different reasons, such as the high failure rate of the early designs. Concern remains regarding the longevity of TEA implants, especially in younger patients. The main cause of revision of the implant is usually related to the phenomenon of aseptic loosening mainly due to the cement-bone interface failure. Aim of this work is the biomechanical analysis of a new elbow prosthesis to investigate the mechanical behaviour at the cement-bone interface. For this reason, a musculoskeletal model…
Kinematics of the ulna during pronation and supination in a cadaver study: implications for elbow arthroplasty
2003
Objective. Aim of this study was to exactly describe and quantify kinematics of the ulna during pro- and supination. Design. Biomechanical study in fresh frozen cadavers. Background. A previous MRI study revealed a varus/valgus motion of the ulna averaging 7.1° during pro-/supination. Axial rotation, however, could not be quantified. Methods. Sixteen arms were examined in a new apparatus that fixed the humerus on a template and allowed forearm rotation. Motion of a Kirschner wire placed in the ulna was recorded in steps of 30° by two perpendicularly arranged charge coupled device cameras during pro- and supination. Results. From supination to pronation the ulna showed a semi-lunar evasive m…
Morphomechanics of the humero-ulnar joint: I. Joint space width and contact areas as a function of load and flexion angle
1995
BACKGROUND Previous studies have shown that the trochlear notch is deeper than necessary for an exact fit with the humerus. However, humero-ulnar joint space width and contact areas have so far not been quantified for variations in the load and angle of flexion. METHODS Six fresh cadaveric specimens were investigated at 30 degrees, 60 degrees, 90 degrees, and 120 degrees of flexion and at loads of 25 and 500 N, simulating resisted elbow extension. The joint space width and contact were determined, using polyether casting material. RESULTS At 25 N all joints made contact in the ventral and dorsal aspects of the articular surfaces, whereas in the depth of the trochlear notch the joint space w…
Ultrasound-guided musculoskeletal interventional procedures around the elbow, hand and wrist excluding carpal tunnel procedures.
2021
Ultrasound is a fast, reliable and radiation-free method for the assessment of a wide range of pathological conditions, as well as for the guidance of percutaneous interventional procedures around the elbow, hand and wrist. Intraarticular and periarticular interventional procedures can be easily performed under continuous ultrasound monitoring to ensure correct needle positioning and medication delivery to a specific target. The most common ultrasound-guided procedures performed around the elbow, wrist, and hand are described in this review, excluding carpal tunnel procedures. Specifically, elbow steroid injections are performed in patients with inflammatory disorders, while hyaluronic acid…