Search results for "LBE"

showing 10 items of 1617 documents

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

ABCC1 ATP binding cassette subfamily C member 1IC50 half maximal inhibitory concentrationMultidrug resistancePharmacologyNADPH reduced nicotinamide adenine dinucleotide phosphateF bioavailabilitychemistry.chemical_compoundPCR polymerase chain reaction0302 clinical medicineMDR multidrug resistanceECL electrochemiluminescencet1/2 elimination half-lifeLC–MS liquid chromatography coupled with mass spectrometryN.D. not detectedGeneral Pharmacology Toxicology and PharmaceuticsBBB blood–brain barriermedia_commonATF3 activating transcription factor 30303 health sciencesChemistryABC ATP-binding cassetteNMPA National Medical Products AdministrationPXR pregnane X receptorSDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresisHBSS Hankʹs balanced salt solutionABCB1Combination chemotherapyProdrugMarsdenia tenacissimaCmax peak concentrationPaclitaxelGAPDH glyceraldehyde-3-phosphate dehydrogenase030220 oncology & carcinogenesisBHI brain heart infusionOriginal ArticleAUC0–∞ area under plasma concentration vs. time curveMRT mean residence timeDrugmedia_common.quotation_subjectRM1-950Vd volume of distributionABCB1 ATP binding cassette subfamily B member 1UIC-2 mouse monoclonal ABCB1 antibodyABCG2 ATP binding cassette subfamily G member 2Combination chemotherapyCYP cytochrome P450 isozymePI propidium iodideTEER transepithelial electrical resistance03 medical and health sciencesPBS phosphate buffer salineFBS fetal bovine serumDox doxorubicinIn vivoPOP polyoxypregnanemedicine030304 developmental biologyEVOM epithelial tissue voltohmmeterTmax time for peak concentrationCancerLBE lowest binding energyPE phycoerythrinmedicine.diseaseMultiple drug resistancePolyoxypregnanePapp apparent permeabilityN.A. not applicableCancer cellH&E hematoxylin and eosinMDR1a multidrug resistance protein 1aTherapeutics. PharmacologyqPCR quantitative PCRM. tenacissima Marsdenia tenacissimaCL clearanceSD standard derivationActa Pharmaceutica Sinica B
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STRESS E SODDISFAZIONE LAVORATIVA DEL PERSONALE FRONTLINE NELLE ORGANIZZAZIONI ALBERGHIERE

2011

ALBERGHIERESettore M-PSI/06 - Psicologia Del Lavoro E Delle OrganizzazioniPERSONALE FRONTLINE
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ALBERTO CALZA BINI ARCHITETTO (1881-1957)

2011

ALBERTO CALZA BINIARCHITETTOSettore ICAR/18 - Storia Dell'Architettura
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Leon Battista Alberti archeologo

2007

Il Convegno rientra nelle celebrazioni ufficiali per il VI centenario della nascita del grande umanista del Quattrocento italiano. Il contributo, unico nel panorama della critica albertiana, mira a mettere a fuoco le propensioni antiquarie e archeologiche dell'Alberti, inquadrando questi interessi nel vasto panorama della cultura antiquaria del Quattrocento italiano. Ne rivela anche aspetti significativi nel suo concreto operare come architetto e ne ricostruisce le pratiche della ricerca sui monumenti antichi di Roma e di molte altre parti dell'Italia.

ANTIQUARIALEON BATTISTA ALBERTIARCHITETTURAUMANESIMOSTORIA DELL'ARCHEOLOGIASettore L-ANT/07 - Archeologia ClassicaLeon Battista Alberti storia dell'archeologia storia dell'architettura
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The large trans-Neptunian object 2002 TC 302 from combined stellar occultation, photometry, and astrometry data

2020

All authors: Ortiz, J. L.; Santos-Sanz, P.; Sicardy, B.; Benedetti-Rossi, G.; Duffard, R.; Morales, N.; Braga-Ribas, F.; Fernández-Valenzuela, E.; Nascimbeni, V.; Nardiello, D.; Carbognani, A.; Buzzi, L.; Aletti, A.; Bacci, P.; Maestripieri, M.; Mazzei, L.; Mikuz, H.; Skvarc, J.; Ciabattari, F.; Lavalade, F. Scarfi, G.; Mari, J. M.; Conjat, M.; Sposetti, S.; Bachini, M.; Succi, G.; Mancini, F.; Alighieri, M.; Dal Canto, E.; Masucci, M.; Vara-Lubiano, M.; Gutiérrez, P. J.; Desmars, J.; Lecacheux, J.; Vieira-Martins, R.; Camargo, J. I. B.; Assafin, M.; Colas, F.; Beisker, W.; Behrend, R.; Mueller, T. G.; Meza, E.; Gomes-Junior, A. R.; Roques, F.; Vachier, F.; Mottola, S.; Hellmich, S.; Campo …

Absolute magnitude010504 meteorology & atmospheric sciencesFOS: Physical sciencesAstrophysicsKuiper belt objects: individual: 2002 TC30201 natural sciencesOccultationlaw.inventionTelescopePhotometry (optics)lawGeometric albedoFísica Aplicada0103 physical sciencesTrans-Neptunian object010303 astronomy & astrophysicsComputingMilieux_MISCELLANEOUS0105 earth and related environmental sciencesPhysics[PHYS]Physics [physics]Earth and Planetary Astrophysics (astro-ph.EP)photometric [Techniques]Astronomy and Astrophysicsgeneral [Kuiper belt]Astrometryindividual: 2002 TC302 [Kuiper belt objects]AstrometryAstrometry; Kuiper belt objects: individual: 2002 TC302; Kuiper belt: general; Occultations; Techniques: photometricLight curveSpace and Planetary Science[SDU]Sciences of the Universe [physics]Kuiper belt: generalOccultations[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]Techniques: photometricAstrophysics - Earth and Planetary AstrophysicsAstronomy & Astrophysics
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Àguila imperial ibèrica, Águila imperial ibérica (VER0000158)

1902

Altres noms vulgars: Adalbert's Eagle (Anglès), Aigle ibérique (Francès), Spanischer kaiseradler (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 4-2 Valencia 00/00/1902 Juvenil

AccipitridaeRapaces diurnas: águilas buitres y halconesAquila adalberti (C. L. Brehm 1861)
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Older people’s participation in political organizations: The role of generativity and its impact on well-being

2017

Aging population has increased a global concern to keep seniors active and healthy. Civic participation, in particular, has been highlighted for its social and community benefits and its impact on elders’ health and well-being. To date, however, most studies have explored volunteering; other types of civic activities, such as political participation, are largely overlooked. This study analyzes the relationship between older people’s active involvement in political organizations, generativity, and hedonic and eudaimonic well-being. We selected two samples of Spanish older people: a sample of elders actively involved in political organizations (n = 97) and a comparison group (n = 85). Measure…

Active involvementPopulation050109 social psychologySample (statistics)EudaimoniaEducationCIENCIAS SOCIALES03 medical and health sciencesPolitics030502 gerontology0501 psychology and cognitive scienceseducationeducation.field_of_studyGenerativityhedonic wellbeing05 social scienceseudaimonic wellbeingPsicologíahumanitiesgenerativityWell-beingGeriatrics and Gerontology0305 other medical scienceOlder peoplePsychologypolitical participationSocial psychologyEducational Gerontology
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Evapotranspiration from an Olive Orchard using Remote Sensing-Based Dual Crop Coefficient Approach

2013

A remote sensing-based approach to estimate actual evapotranspiration (ET) was tested in an area covered by olive trees and characterized by Mediterranean climate. The methodology is a modified version of the standard FAO-56 dual crop coefficient procedure, in which the crop potential transpiration, T p, is obtained by directly applying the Penman-Monteith (PM) equation with actual canopy characteristics (i.e., leaf area index, albedo and canopy height) derived from optical remote sensing data. Due to the minimum requirement of in-situ ancillary inputs, the methodology is suitable also for applications on large areas where the use of tabled crop coefficient values become problematic, due to…

Actual evapotranspirationCanopyEddy covarianceAlbedoPlant transpiration; Optical remote sensing; Dual crop coefficient; Actual evapotranspirationOlive treesSettore AGR/03 - Arboricoltura Generale E Coltivazioni ArboreeCrop coefficientDual crop coefficientEvapotranspirationOptical remote sensingPlant transpirationSettore AGR/08 - Idraulica Agraria E Sistemazioni Idraulico-ForestaliEnvironmental scienceLeaf area indexWater Science and TechnologyCivil and Structural EngineeringTranspirationRemote sensingWater Resources Management
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Conversazione con Adalberto Abbate

2011

Adalberto Abbate
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Design and Implementation of a Data Acquisition System for R Peak Detection in Electrocardiograms

2018

This paper presents a data acquisition system for the R peak detection in electrocardiograms. R wave is one of the most important sections of the QRS complex, which has an essential role in diagnosis of heart rhythm irregularities. This paper employs Hilbert transform and adaptive threshold technique for the detection of R-peak. The performance of the system was tested using standard ECG waveform records from the MIT-BIH arrhythmia database. In addition, tests were carried out using the sensors Single Lead Heart Rate Monitor for real-time data processing Design and Implementation of a Data Acquisition System for R Peak Detection in Electrocardiograms | Request PDF. Available from: https://w…

Adaptive ThresholdHilbert TransformElectrocardiogram
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