Search results for "LDH"
showing 10 items of 1015 documents
The Norwegian childhood cancer biobank
2021
Background - The rapidly expanding era of “omics” research is highly dependent on the availability of quality-proven biological material, especially for rare conditions such as pediatric malignancies. Professional biobanks provide such material, focusing on standardized collection and handling procedures, distinctive quality measurements, traceability of storage conditions, and accessibility. For pediatric malignancies, traditional tumor biobanking is challenging due to the rareness and limited amount of tissue and blood samples. The higher molecular heterogeneity, lower mutation rates, and unique genomic landscapes, however, renders biobanking of this tissue even more crucial. Aim - The ai…
Systems of attention to childhood education in Latin America and The Caribbean (AL & C)
2019
El propósito de este artículo se centra en conocer cómo se estructuran los sistemas educativos de los países de América Latina y la Región de Caribe respecto al tramo de la primera infancia. Se llevó a cabo el análisis de diversos informes internacionales y documentos oficiales sobre los avances de los programas en cuanto a cobertura, inversión, regulaciones, entre otros. La naturaleza de carácter documental de este trabajo permite una aproximación comparada entre los países acerca del modo en que aborda la escolarización de la primera infancia en cada país de la región. Uno de los logros más destacados es el vinculado a la expansión del primer nivel educativo y a la cobertura alcanzada. Ca…
Clinico-Immunological Status and Neurocognitive Function of Perinatally Acquired HIV-Positive Children on cART: A Cross-Sectional Correlational Study…
2020
Despite the undisputed benefits of combination antiretroviral therapy (cART), perinatally acquired human immunodeficiency virus (PHIV) children on treatment often present with a spectrum of neurological deficits known as HIV-associated neurocognitive impairment. Even higher CD4 cell count does not seem to prevent the development of neurocognitive impairment in children with PHIV. While CD4 cell count has shown to have the greatest prognostic value, its association with neurocognitive abilities remains to be clarified. This study aimed at determining the correlation between plasma CD4+ lymphocyte and neurocognitive function in children with PHIV on cART. In total, 152 purposively recruited h…
Acute Respiratory Distress Syndrome Associated with Tumor Lysis Syndrome in a Child with Acute Lymphoblastic Leukemia
2015
Tumor lysis syndrome is a serious and dangerous complication usually associated with antiblastic treatment in some malignancies characterized by high cell turn-over. Mild or severe electrolyte abnormalities including high serum levels of uric acid, potassium, phosphorus, creatinine, bun and reduction of calcium can be responsible for multi-organ failure, involving mostly kidneys, heart and central nervous system. Renal damage can be followed by acute renal failure, weight gain, progressive liver impairment, overproduction of cytokines, and subsequent maintenance of multi-organ damage. Life-threatening acute respiratory failure associated with tumor lysis syndrome is rare. We describe a chil…
Mother's Death: A Turning Point in the Lives of Charles Dickens's David Copperfield and Lev Tolstoy's Nikolay Irtenev
2022
Although it is not possible to establish exactly when Lev Tolstoy started reading Charles Dickens, it was in the 1850s, he was reading David Copperfield, which was one of his most favourite novels by the English writer. David Copperfield is probabiy the most popular of all Dickens’s novels, and it is certainly the most autobiographical. The tendency to combine personal with general in an ambiguous generic package was also present from the beginning of Tolstoy’s career. His Childhood can be described as a pseudo-autobiography that imitates autobiography in all aspects, except one: its author and narrator are not the same person. A strong mother-son relationship is clearly visible in David Co…
Unaccompanied minors in Sicily: promoting conceptualizations of child well-being through children’s own subjective realities
2020
Understanding unaccompanied minors’ (UAMs’) individual migration journeys and aspirations and hopes helps make sense of the meaning they ascribe to their personal and social reality in their quest for integration and mobility. Although the well-being of children is considered to be of the utmost importance in contemporary times, we still lack good evidence of what children themselves regard as key facets of this, from their own life experiences. Identifying different domains and dimensions of children’s well-being and touching upon its multifaceted nature, this study presents an alternative framework, showing how the quality of the reception path is fundamental to having successful results …
Environmental factors that distinguish between clinical and healthy samples with childhood experiences of abuse and neglect
2015
<b><i>Background:</i></b> Childhood maltreatment is associated with a wide range of problems in adulthood. However, specific environmental factors (either positive or negative) influence mental health outcomes in maltreated children. The present study investigated the effect of environmental factors by comparing a group of clinical participants with experiences of abuse/neglect with a healthy group with similar patterns of experiences. Environmental factors selected were: separation from parents, financial hardship, parental psychiatric disorders, and low social involvement. <b><i>Method:</i></b> The study included 55 mixed clinical participan…
Childhood adversity and psychosis: a systematic review of bio-psycho-social mediators and moderators.
2020
AbstractThe association between childhood adversity (CA) and psychosis has been extensively investigated in recent years. An increasing body of research has also focused on the mediating or moderating role of biological and psychological mechanisms, as well as other risk factors that might account for the link between CA and psychosis. We conducted a systematic search of the PsychINFO, Embase, Ovid, and Web of Science databases for original articles investigating the role of genetic vulnerabilities, environmental factors, psychological and psychopathological mechanisms in the association between CA and psychosis up to August 2019. We included studies with individuals at different stages of …
Does Childhood Psychological Abuse Contribute to Intimate Partner Violence Victimization? An Investigation Using the Childhood Experience of Care and…
2018
International audience; Although psychological abuse is recognized as a particularly insidious form of child abuse, research on the impact of this type of abuse related to intimate partner violence (IPV) is scant. This study examined the contribution of childhood psychological abuse to IPV in female victims and non-victims. Furthermore, it investigated the role of cumulative abuse in predicting IPV. The study included 38 women victims of IPV and 40 non-IPV women. All participants were investigated using the Childhood Experience of Care and Abuse Interview (CECA); the Revised Conflict Tactics Scale (CTS2) and the IPV History Interview were used to assess IPV in the last year and lifetime, re…
Emotion regulation strategies modulate the effect of adverse childhood experiences on perceived chronic stress with implications for cognitive flexib…
2020
Exposure to early life adversity is associated with chronic stress and a range of stress-related health problems in adulthood. Since chronic stress debilitates activity in the prefrontal cortex (pFC), maladaptive regulatory strategies in response to stress have been proposed as one explanation for the impact of early life adversity on health outcomes in adulthood. We conducted a study to examine the impact of adverse childhood experiences (ACEs) on cognitive flexibility, a key executive function implicated in activity in the pFC, in a sample of adults (N = 486). Additionally, we investigated whether perceptions of chronic stress in adulthood would mediate the influence of ACEs on cognitive …