Search results for "LEEP"
showing 10 items of 985 documents
Is APOE ε4 associated with cognitive performance in early MS?
2020
ObjectiveTo assess the impact of APOE polymorphisms on cognitive performance in patients newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS).MethodsThis multicenter cohort study included 552 untreated patients recently diagnosed with CIS or RRMS according to the 2005 revised McDonald criteria. The single nucleotide polymorphisms rs429358 (ε4) and rs7412 (ε2) of the APOE haplotype were assessed by allelic discrimination assays. Cognitive performance was evaluated using the 3-second paced auditory serial addition test and the Multiple Sclerosis Inventory Cognition (MUSIC). Sum scores were calculated to approximate the overall cognitive performance and memo…
Behavioural sensitization to repeated sleep deprivation in a mice model of mania.
2008
Sensitization to the effect of stress has been hypothesized as a mechanism to explain episode recurrence and cycle acceleration in bipolar disorder. Naturalistic observations and experimental work in human patients suggested that sleep deprivation can trigger manic episodes of illness. In rats sleep deprivation (SD) with the platform method caused mania-like behaviours thus providing an animal model of mania with face, construct, and predictive validity. In the present study we administered SD or control stress to male CD1 mice following a dose-response protocol based on time of exposure to the experimental conditions (6, 12 or 24 h) and repetition of treatment (three times). SD, but not st…
Treatment of snoring disorder with a non-ablactive Er:YAG laser dual mode protocol. An interventional study
2020
Background Snoring disorder is a common problem among world population. Treatment modalities may involve surgical and non-surgical procedures. As main objective we proposed to evaluate the efficacy of non-ablative Er:YAG laser in the treatment of snoring disorder. Material and Methods We performed an interventional study in 30 patients with snoring disorders. Three sessions were performed with Er:YAG laser 2940nm in long pulse mode (2J/cm2) and smooth mode (10-8J/cm2) in oropharynx region. We analyzed the efficacy of this protocol using questionnaires for snoring intensity, snoring related characteristics of quality of life (including the Epworth sleepness scale and OHIP-14), the satisfacti…
Where do you live? North versus Central-South differences in relation to Italian patients with oral lichen planus: a cross-sectional study from the S…
2022
Abstract Background Oral lichen planus (OLP) is an immune-mediated inflammatory chronic disease of the oral mucosa, with different patterns of clinical manifestations which range from keratotic manifestations (K-OLP) to predominantly non-keratotic lesions (nK-OLP). The aim of the study was to analyze the differences in the clinical, psychological profile and symptoms between Italian patients of the North and Central-South with K-OLP and nK-OLP. Methods 270 K-OLP and 270 nK-OLP patients were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A), Pittsburgh Sleep Quality In…
Assessment of sleep disturbance in oral lichen planus and validation of PSQI: A case-control multicenter study from the SIPMO (Italian Society of Ora…
2021
Background: The wellbeing of oral lichen planus patients (OLPs) may be strongly influenced by a poor quality of sleep (QoS) and psychological impairment. The aims were to analyze the prevalence of sleep disturbance, anxiety, and depression in OLPs and to validate the Pittsburgh Sleep Quality Index (PSQI) in OLPs. Methods: Three hundred keratotic OLPs (K-OLPs), 300 with predominant non-keratotic OLP (nK-OLPs), and 300 controls were recruited in 15 Italian universities. The PSQI, Epworth Sleepiness Scale (ESS), Hamilton Rating Scales for Depression and Anxiety (HAM-D and HAM-A), Numeric Rating Scale (NRS), and Total Pain Rating Index (T-PRI) were administered. Results: Oral lichen planus pati…
Three-Way Interactions Among Interruptions/Multitasking Demands, Occupational Age, and Alertness: A Diary Study
2015
In this study, we examined the within-person relationships between workday “cognitive” stressors (multitasking demands and workflow interruptions) and strain (situational well-being throughout the day and irritation in the evening). We hypothesized that occupational age, in terms of job tenure and an indicator of functional age (alertness), would moderate these relationships in that employees with low experience and low alertness would suffer most from the stressors. We conducted a 5-day diary study in a sample of 123 nurses, with 4 measurements per day (3 taken during the work shift and 1 taken in the evening), and 1 survey (occupational age) and computer-based cognitive performance test b…
Testing cross-lagged relationships between work-related rumination and well-being at work in a three-wave longitudinal study across 1 and 2 years
2019
The aim of this three-wave longitudinal study conducted among 664 Finnish employees was to examine the cross-lagged relationships between various work-related ruminative thoughts (affective rumination, problem-solving pondering, lack of detachment from work) during off-job time and employee well-being (exhaustion, vigour). We tested normal, reversed, and reciprocal temporal relationships across 1 and 2 years using structural equation modelling. The analyses lent most support to the reversed temporal relationships, showing first that high exhaustion predicted low problem-solving pondering 2 years later and second, that high vigour predicted low affective rumination both 1 and 2 years later. …
Being mindful at work and at home
2018
In this daily diary study, we examined the moderating role of employee domain‐specific mindfulness within the stressor–detachment model (Sonnentag & Fritz, 2015, Journal of Organizational Behavior, 36, 72). According to the stressor–detachment model, emotional and quantitative demands should be associated with decreased psychological detachment after work, which in turn is associated with decreased well‐being (i.e., low positive affect and high negative affect) at bedtime. Moreover, we proposed that both mindfulness at work and home should buffer the relations between job demands and psychological detachment and between psychological detachment and well‐being. Sixty‐five employees compl…
The Moderating Role of Work-Related Rumination in Nurses’ Sleep Quality Trajectory During Morning Shift Work
2020
Abstract. This diary study investigated nurses’ recovery after transitioning to morning shift work (i.e., their short-term adaptation to shift work) by examining the change trajectory of sleep quality over the course of five consecutive morning shifts. Results of latent growth analyses ( N = 132) showed that nurses’ sleep quality started at low levels and increased rapidly in the beginning until it stabilized toward the end of the shift work period. Moreover, work-related rumination moderated the sleep quality trajectory. When rumination was low, nurses’ sleep quality showed a quadratic trajectory, whereas when rumination was high, sleep quality showed a flatter and linear trajectory, sugg…
Craniofacial Signs, Symptoms and Orthodontic Objectives of Paediatric Obstructive Sleep Apnoea
2019
The study of craniofacial growth and development has a long history in the disciplines of Paediatric Dentistry and Orthodontics. Unbalanced facial growth is known to be causative for dental misalignment and malocclusion. However, historically, little emphasis has been placed on the possible link to obstructive sleep apnoea. Through greater understanding from contemporary studies and reflections from past research, we now are bringing to light the interrelationships of all proximal structures in the many chronic issues that ail our children.