Search results for "LEEP"

Are long-haul truck drivers unusually alert? A comparison with long-haul airline pilots.

2020

Abstract Background Recent studies suggest heavy vehicle drivers self-estimate their sleepiness unexpectedly low during night duties. The present study compared sleepiness ratings of long-haul truck drivers with those of long-haul airline pilots during night and non-night duties. In addition, the correspondence between self-rated manifest and predicted latent sleepiness was examined in the two groups. Methods Twenty-two drivers and 33 pilots participated. Their working hours, sleep, on-duty sleepiness, and use of sleepiness countermeasures were measured in naturalistic conditions. Predictions of latent sleepiness were based on the measurements of working hours and sleep using the Sleep/Wake…

The self-reported causes of sleepiness in shift-working tram and truck drivers

2021

Identifying the causes of sleepiness in various safety-critical work environments is neces-sary for implementing more efficient fatigue management strategies. In transportation, little is known about drivers' own perceptions of these causes. Therefore, we instructed shift-working tram (n = 23) and long-haul truck drivers (n = 52) to report at the end of their shifts what made them sleepy if they felt so. These self-reports, measured on-duty sleepiness, and sleep amounts were recorded on every shift over a period of 2-3 weeks per driver. The causes of sleepiness were queried with smartphone applications and sleep logs. Sleepiness was measured with the Karolinska Sleepiness Scale (KSS) and sl…

Accumulation of sleep loss among shift-working truck drivers.

2021

Sleep loss is known to contribute to road traffic accidents. Professional drivers are vulnerable to curtailment of sleep due to long driving bouts and shift work. To fill in the gap in the literature related to the buildup of sleep loss in irregular shift systems, we recorded the sleep and working hours of 47 shift-working long-haul truck drivers during a two-week period. Sleep (time in bed) was verified by actigraphy and sleep logs. Sleepiness was measured using the Karolinska Sleepiness Scale (KSS). Individual sleep need was based on self-assessments. We examined the accumulated sleep versus self-reported sleep need across the study period, using midnights as points of observation, and th…

Predicting 19F NMR Chemical Shifts: A Combined Computational and Experimental Study of a Trypanosomal Oxidoreductase–Inhibitor Complex

2020

Abstract The absence of fluorine from most biomolecules renders it an excellent probe for NMR spectroscopy to monitor inhibitor–protein interactions. However, predicting the binding mode of a fluorinated ligand from a chemical shift (or vice versa) has been challenging due to the high electron density of the fluorine atom. Nonetheless, reliable 19F chemical‐shift predictions to deduce ligand‐binding modes hold great potential for in silico drug design. Herein, we present a systematic QM/MM study to predict the 19F NMR chemical shifts of a covalently bound fluorinated inhibitor to the essential oxidoreductase tryparedoxin (Tpx) from African trypanosomes, the causative agent of African sleepi…

turbinate surgery by radiofrequency for sleep-disordered breathing

2003

Blir behovet for søvn prioritert på intensiv? : - en kvantitativ undersøkelse av norske intensivavdelingers praksis rundt søvn og sedering

2014

Masteroppgave i spesialsykepleie – Universitetet i Agder 2014 Background: Patients in the intensive care units suffer from sleep disturbances. The lack of sleep may cause physical and psychological disturbances, increased morbidity and prolonged stay. The nurses evaluate patients’ sleep mainly on their own perception. No registration of sleeping and sedation practices has been conducted in intensive care units in Norway. Aim: To get insight into Norwegian intensive care nurses sleeping and sedation practices and what kind of interventions are common to conduct promoting better sleep and to explore if sedation- or sleep assessment tools, or sedation- or sleep protocols were used. Method: A s…

Sleep patterns and psychosocial health of parents of preterm and full-born infants: a prospective, comparative, longitudinal feasibility study

2022

Abstract Background The early birth and hospitalization of a preterm infant in neonatal intensive care unit can produce several emotional and behavioural responses including sleep problems for parents. Few studies have explored sleep and its associations with health and HRQoL over time in this vulnerable parent population. This purpose of this study was to evaluate the feasibility of a prospective, comparative, longitudinal study of the sleep patterns and psychosocial health of preterm and full-born infants’ parents during the first postpartum year. Methods A prospective, comparative, longitudinal feasibility study was conducted. Parents of preterm infants were compared to parents of full-b…

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review.

2021

AbstractSleep disorders are common among the general population and can generate health problems such as insomnia and anxiety. In addition to standard drugs and psychological interventions, there are different complementary plant-based therapies used to treat insomnia and anxiety. This review aimed to find and examine the most recent research on the use of herbal medicines for treating anxiety and insomnia as compiled from clinical trials, as well as to assess the safety and efficacy of these medicines and to elucidate their possible mechanisms of action. The process entailed a search of PubMed, Scopus, and the Cochrane Library databases from 2010 to 2020. The search terms included “sleep d…

Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea.

2012

Background: Intermittent hypoxia and obesity which are two pathological conditions commonly found in patients with obstructive sleep apnea (OSA), potentially enhance cancer progression. Objective: To investigate whether obesity and/or intermittent hypoxia (IH) mimicking OSA affect tumor growth. Methods: A subcutaneous melanoma was induced in 40 mice [22 obese (40–45 g) and 18 lean (20–25 g)] by injecting 106 B16F10 cells in the flank. Nineteen mice (10 obese/9 lean) were subjected to IH (6 h/day for 17 days). A group of 21 mice (12 obese/9 lean) were kept under normoxia. At day 17, tumors were excised, weighed and processed to quantify necrosis and endothelial expression of vascular endothe…

Miega kvalitātes rādītāju saistība ar vizuālās uztveres spējām

2020

Bakalaura darba pētījuma mērķis bija noskaidrot, vai cilvēkiem ar augstākiem miega kvalitātes rādītājiem ir precīzāka vizuālā uztvere. Pētījumā piedalījās 56 pieaugušie (34 sievietes; 22 vīrieši) vecumā no 18 līdz 63 gadiem (M=36,60, SD=12,90). Pētījumā tika izmantotas šādas metodes: Pitsburgas miega kvalitātes indeksa aptauja un Vizuālās uztveres tests. Pētījumā iegūtie rezultāti norāda, ka konkrētajā izlasē pastāv statistiski nozīmīgas korelācijas. Uzrādījās statistiski nozīmīga negatīva korelācija starp vizuālās uztveres testa rezultātiem un miega traucējumu apakšskalu; starp vizuālās uztveres testa rezultātiem un iemigšanas laika apakšskalu; starp vizuālās uztveres testa rezultātiem un …