Search results for "LENI"

Tumor cell specific toxicity of Inula helenium extracts.

2006

The aim of the research program was to identify botanical extracts with antineoplastic activity. In this respect extracts prepared from Inula helenium roots showed a remarkable activity. As evidenced by the MTT assay, the Inula helenium extract revealed a highly selective toxicity toward four different tumor cell lines (HT-29, MCF-7, Capan-2 and G1), but a much lower toxicity against healthy human peripheral blood lymphocytes (PBLs) from two donors. The extract-induced death of tumor cells was studied extensively by electron microscopy. There was a remarkable similarity of morphological alterations observed in the four cell lines: patchy chromatin condensations, cytoplasmic vesiculation, sw…

A Synthetic Route to 3-(Heteroaryl)-7-hydroxycoumarins Designed for Biosensing Applications

2014

A straightforward method to synthesize 3-(2-benzimidazolyl)-7-hydroxycoumarins, based on the condensation reaction of 7-acetoxy-3-formylcoumarin with various C- and/or N-substituted ortho-phenylenediamine derivatives is presented. This unusual approach proved particularly effective for introducing different hydrophilic groups (carboxylic or sulfonic acids or trimethylalkylammonium moieties) onto the heteroaryl scaffold, leading to cyan-green emitting coumarins that were both water-soluble and strongly fluorescent under physiological conditions. The further extension of this condensation reaction to bis(2-aminophenyl)diselenide enabled the first synthesis of 3-(2-benzoselenazolyl)-7-hydroxyc…

Self-care and total care: the twofold return of care in twentieth-century thought

2020

The paper studies two fundamentally different forms in which the concept of care makes its comeback in twentieth-century thought. We make use of a distinction made by Peter Sloterdijk, who argues that the ancient and medieval ‘ascetic’ ideal of self-enhancement through practice has re-emerged in the nineteenth and twentieth centuries, particularly in the form of a rehabilitation of the Hellenistic notion of self-care (epimeleia heautou) in Michel Foucault’s late ethics. Sloterdijk contrasts this return of self-care with Martin Heidegger’s concept of being-in-the-world as ‘total care’ (Sorge), an utterly ‘secularized’ understanding of the human being as irreducibly world-embedded that reject…

Hypoxia-induced dysfunction of rat diaphragm

2004

Contains fulltext : 47331.pdf (Publisher’s version ) (Closed access) Oxidants may play a role in hypoxia-induced respiratory muscle dysfunction. In the present study we hypothesized that hypoxia-induced impairment in diaphragm contractility is associated with elevated peroxynitrite generation. In addition, we hypothesized that strenuous contractility of the diaphragm increases peroxynitrite formation. In vitro force-frequency relationship, isotonic fatigability, and nitrotyrosine levels were assessed under hypoxic (Po(2) approximately 6.5 kPa) and hyperoxic (Po(2) approximately 88.2 kPa) control conditions and also in the presence of authentic peroxynitrite (60 min), ebselen (60 min), and t…

Observaciones sobre los dinoflagelados (Pyrrhophyta) de las costas de Castellón (España)

1991

espanolEn este trabajo se presentan 27 especies de dinoflagelados (Pyrrhophyta), procedentes de muestreos realizados durante el otono de 1989, en la zona neritica del Mediterraneo frente al puerto de Castellon (U.T.M. 31S BE451293). Se comentan algunas caracteristicas morfometricas de especies pertenecientes a los generos: Prorocentrum, Amphisolenia, Dinophisis,Ornithocercus, Peridinium,Ceratocorys y Ceratium. La especie Dinophisis schuetti Murray et Whitting, 1899, se cita por primera vez para esta costa. EnglishIn the present work, 27 species of dinoflagellates (Pyrrhophyta) were determinated. The samples were taken in the 1989 autumn in the Mediterranean neritic zone near the harbour of …

Antioxidants: Role in the prevention and treatment of bronchopulmonary dysplasia

2022

Bronchopulmonary dysplasia (BPD) is one of the major causes of chronic respiratory diseases among infants. Both pharmacological and nonpharmacological approaches have been proposed for its management. Since oxidative stress is known to play a pivotal role in the pathogenesis of BPD, it is reasonable to consider the potential of antioxidant strategies in the prevention and treatment of this condition. Indeed, antioxidants can prevent or inhibit substrate oxidation. Some studies have evaluated the efficacy of the exogenous administration of vitamins and micronutrients in reducing the propagation of free radicals through their scavenging capacity. Nonetheless, encouraging preclinical results d…

Structural transformations in amorphous selenium as studied by the differential thermal analysis and exoelectron emission technique

2007

The parameters (temperature, activation energy) of the surface and volume glass transition (retrification process) in amorphous selenium produced by rapid quenching of the liquid phase have been determined using the EEE and DTA techniques. EEE is a surface effect connected with structural transformations in the surface layer whereas the DTA measurements give the information about the transformations occurring in the volume of the sample. It has been found that the surface retrification of selenium occurs with activation energy smaller than the volume retrification, both observed in the first heating run. The value of activation energy for the volume retrification measured in the second DTA …

Tectono-biosedimentary recordings at the Lias-Dogger transition: example of the Quercy carbonate platform (Aquitaine Basin, France).

2007

AbstractOn the eastern edge of the Aquitaine Basin, the Lias-Dogger transition and the events, which occurred during this time interval are studied in the Quercy sedimentary basin. Stratigraphic correlations are proposed using a biochronological calibration based on the determination of numerous ammonites and brachiopods. Facies analyses using statistical processing integrate the presence of faults and tectonic compartments and lead to reconstruction of palaeoenvironments in space and time. The paper includes the description of system tracts following Haq et al. [1987] and Vail et al. [1991], and twelve palaeogeographic maps of the area studied. The objectives are to distinguish the various…

Lo nuestro es lo de todos

2008

Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids

2005

Dietary vegetable oils and fish oils rich in PUFA (polyunsaturated fatty acids) exert hypocholesterolaemic and hypotriglyceridaemic effects in rodents. The plasma cholesterol-lowering properties of PUFA are due partly to a diminution of cholesterol synthesis and of the activity of the rate-limiting enzyme HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase). To better understand the mechanisms involved, we examined how tuna fish oil and individual n−3 and n−6 PUFA affect the expression of hepatic FPP synthase (farnesyl diphosphate synthase), a SREBP (sterol regulatory element-binding protein) target enzyme that is subject to negative-feedback regulation by sterols, in co-ordination …