Search results for "LEPTOGENESIS"
showing 10 items of 57 documents
Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry.
2017
Epilepsy is a highly common chronic neurological disorder, manifested in many different types, affecting ~1% of the worldwide human population. The molecular mechanisms of epileptogenesis have not yet been clarified, and pharmacoresistance exhibited by 30-40% of epilepsy patients remains a major obstacle in medical care. Growing evidence indicates a role of lipid signalling pathways in epileptogenesis, thus lipid signals emerge as potential biomarkers for the onset and evolving course of the epileptic disorder, as well as potential therapeutic agents and targets. For this purpose, we applied a lipidomic strategy to unravel lipid alterations in brain regions, periphery tissues and plasma tha…
Microtubule Dynamics and Neuronal Excitability: Advances on Cytoskeletal Components Implicated in Epileptic Phenomena
2020
AbstractExtensive researches have deepened knowledge on the role of synaptic components in epileptogenesis, but limited attention has been devoted to the potential implication of the cytoskeleton. The study of the development of epilepsy and hyperexcitability states involves molecular, synaptic, and structural alterations of neuronal bioelectric activity. In this paper we aim to explore the neurobiological targets involved in microtubule functioning and cytoskeletal transport, i.e. how dynamic scaffolding of microtubules can influence neuronal morphology and excitability, in order to suggest a potential role for microtubule dynamics in the processes turning a normal neuronal network in a hy…
Flavour mixing transport theory and resonant leptogenesis
2021
We derive non-equilibrium quantum transport equations for flavour-mixing fermions. We develop the formalism mostly in the context of resonant leptogenesis with two mixing Majorana fermions and one lepton flavour, but our master equations are valid more generally in homogeneous and isotropic systems. We give a hierarchy of quantum kinetic equations, valid at different approximations, that can accommodate helicity and arbitrary mass differences. In the mass-degenerate limit the equations take the familiar form of density matrix equations. We also derive the semiclassical Boltzmann limit of our equations, including the CP-violating source, whose regulator corresponds to the flavour coherence d…
Leptogenesis with small violation of B-L
2012
We analyze leptogenesis in the context of seesaw models with almost conserved lepton number, focusing on the L-conserving contribution to the flavoured CP asymmetries. We find that, contrary to previous claims, successful leptogenesis is feasible for masses of the lightest heavy neutrino as low as M1 ~ 10^6 GeV, without resorting to the resonant enhancement of the CP asymmetry for strongly degenerate heavy neutrinos. This lower limit renders thermal leptogenesis compatible with the gravitino bound in supersymmetric scenarios.
R parity violation assisted thermal leptogenesis in the seesaw mechanism.
2005
Successful leptogenesis within the simplest type I supersymmetric seesaw mechanism requires the lightest of the three right-handed neutrino supermultiplets to be heavier than $\sim10^9$ GeV. Thermal production of such (s)neutrinos requires very high reheating temperatures which result in an overproduction of gravitinos with catastrophic consequences for the evolution of the universe. In this letter, we let R-parity be violated through a $\lambda_i \hat{N}_i \hat{H}_u \hat{H}_d$ term in the superpotential, where $\hat{N}_i$ are right-handed neutrino supermultiplets. We show that in the presence of this term, the produced lepton-antilepton asymmetry can be enhanced. As a result, even for $\ha…
MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus
2018
Prolonged seizures (status epilepticus, SE) may drive hippocampal dysfunction and epileptogenesis, at least partly, through an elevation in neurogenesis, dysregulation of migration and aberrant dendritic arborization of newly-formed neurons. MicroRNA-22 was recently found to protect against the development of epileptic foci, but the mechanisms remain incompletely understood. Here, we investigated the contribution of microRNA-22 to SE-induced aberrant adult neurogenesis. SE was induced by intraamygdala microinjection of kainic acid (KA) to model unilateral hippocampal neuropathology in mice. MicroRNA-22 expression was suppressed using specific oligonucleotide inhibitors (antagomir-22) and ne…
Mass bounds for baryogenesis from particle decays and the inert doublet model
2014
In models for thermal baryogenesis from particle decays, the mass of the decaying particle is typically many orders of magnitude above the TeV scale. We will discuss different ways to lower the energy scale of baryogenesis and present the corresponding lower bounds on the particle's mass. This is done specifically for the inert doublet model with heavy Majorana neutrinos and then we indicate how to extrapolate the results to other scenarios. We also revisit the question of whether or not dark matter, neutrino masses, and the cosmic baryon asymmetry can be explained simultaneously at low energies in the inert doublet model.
Leptogenesis with a dynamical seesaw scale
2014
In the simplest type-I seesaw leptogenesis scenario right-handed neutrino annihilation processes are absent. However, in the presence of new interactions these processes are possible and can affect the resulting $B-L$ asymmetry in an important way. A prominent example is provided by models with spontaneous lepton number violation, where the existence of new dynamical degrees of freedom can play a crucial role. In this context, we provide a model-independent discussion of the effects of right-handed neutrino annihilations. We show that in the weak washout regime, as long as the scattering processes remain slow compared with the Hubble expansion rate throughout the relevant temperature range,…
Baryogenesis from mixed particle decays
1996
We consider the $CP$ violating asymmetries produced in the decay of heavy particles, studying the effects of heavy particle mixing for arbitrary mass splittings. A considerable enhancement of the asymmetries is achieved when the masses of the mixed states are comparable, and the enhancement is maximal for mass splittings of the order of the widths of the decaying particles. We apply the results to the particular case of heavy scalar neutrino decays relevant for leptogenesis scenarios.
On the full Boltzmann equations for leptogenesis
2009
We consider the full Boltzmann equations for standard and soft leptogenesis, instead of the usual integrated Boltzmann equations which assume kinetic equilibrium for all species. Decays and inverse decays may be inefficient for thermalising the heavy-(s)neutrino distribution function, leading to significant deviations from kinetic equilibrium. We analyse the impact of using the full kinetic equations in the case of a previously generated lepton asymmetry, and find that the washout of this initial asymmetry due to the interactions of the right-handed neutrino is larger than when calculated via the integrated equations. We also solve the full Boltzmann equations for soft leptogenesis, where t…