Search results for "LEPTOGENESIS"

Role(s) of the 5-HT2C receptor in the development of maximal dentate activation in the hippocampus of anesthetized rats.

2014

Aims: Substantial evidence indicates that 5-HT2C receptors are involved in the control of neuronal network excitability and in seizure pathophysiology. Here, we have addressed the relatively unexplored relationship between temporal lobe epilepsy (TLE), the most frequent type of intractable epilepsy, and 5-HT2CRs. Methods: In this study, we investigated this issue using a model of partial complex (limbic) seizures in urethane-anesthetized rat, based on the phenomenon of maximal dentate activation (MDA) using 5-HT2C compounds, electrophysiology, immunohistochemistry, and western blotting techniques. Results: The 5-HT2C agonists mCPP (1 mg/kg, i.p) and lorcaserin (3 mg/kg, i.p), but not RO60-0…

Leptogenesis without violation of B-L

2009

We study the possibility of generating the observed baryon asymmetry via leptogenesis in the decay of heavy Standard Model singlet fermions which carry lepton number, in a framework without Majorana masses above the electroweak scale. Such scenario does not contain any source of total lepton number violation besides the Standard Model sphalerons, and the baryon asymmetry is generated by the interplay of lepton flavour effects and the sphaleron decoupling in the decay epoch.

Leptogenesis from oscillations and dark matter

2019

An extension of the Standard Model with Majorana singlet fermions in the 1–100 GeV range can explain the light neutrino masses and give rise to a baryon asymmetry at freeze-in of the heavy states, via their CP-violating oscillations. In this paper we consider extending this scenario to also explain dark matter. We find that a very weakly coupled B−L gauge boson, an invisible QCD axion model, and the singlet majoron model can simultaneously account for dark matter and the baryon asymmetry.

Aidnogenesis via Leptogenesis and Dark Sphalerons

2010

We discuss aidnogenesis, the generation of a dark matter asymmetry via new sphaleron processes associated to an extra non-abelian gauge symmetry common to both the visible and the dark sectors. Such a theory can naturally produce an abundance of asymmetric dark matter which is of the same size as the lepton and baryon asymmetries, as suggested by the similar sizes of the observed baryonic and dark matter energy content, and provide a definite prediction for the mass of the dark matter particle. We discuss in detail a minimal realization in which the Standard Model is only extended by dark matter fermions which form "dark baryons" through an SU(3) interaction, and a (broken) horizontal symme…

Insensitivity of leptogenesis with flavour effects to low energy leptonic CP violation

2007

If the baryon asymmetry of the Universe is produced by leptogenesis, CP violation is required in the lepton sector. In the seesaw extension of the standard model with three hierarchical right-handed neutrinos, we show that the baryon asymmetry is insensitive to the Pontecorvo-Maki-Nagakawa-Sakata phases: thermal leptogenesis can work for any value of the observable phases. This result was well known when there were no flavor effects in leptogenesis; we show that it remains true when flavor effects are included.

Thermal leptogenesis in extended supersymmetric seesaw model

2006

We consider an extended supersymmetric SO(10) seesaw model with only doublet Higgs scalars, in which neutrino masses are suppressed by the scale of D-parity violation. Leptogenesis can occur at the TeV scale through the decay of a singlet Sigma, thereby avoiding the gravitino crisis. Washout of the asymmetry can be effectively suppressed by the absence of direct couplings of Sigma to leptons.

Soft leptogenesis in the inverse seesaw model

2006

We consider leptogenesis induced by soft supersymmetry breaking terms ("soft leptogenesis"), in the context of the inverse seesaw mechanism. In this model there are lepton number (L) conserving and L-violating soft supersymmetry-breaking B-terms involving the singlet sneutrinos which, together with the -- generically small-- L-violating parameter responsible of the neutrino mass, give a small mass splitting between the four singlet sneutrino states of a single generation. In combination with the trilinear soft supersymmetry breaking terms they also provide new CP violating phases needed to generate a lepton asymmetry in the singlet sneutrino decays. We obtain that in this scenario the lepto…

Falsifying High-Scale Leptogenesis at the LHC

2013

Measuring a non-zero value for the cross section of any lepton number violating (LNV) process would put a strong lower limit on the washout factor for the effective lepton number density in the early universe at times close to the electroweak phase transition and thus would lead to important constraints on any high-scale model for the generation of the observed baryon asymmetry based on LNV. In particular, for leptogenesis models with masses of the right-handed neutrinos heavier than the mass scale observed at the LHC, the implied large washout factors would lead to a violation of the out-of-equilibrium condition and exponentially suppress the net lepton number produced in such leptogenesis…

2015

Objective Dopamine is an endogenous neuromodulator in cortical circuits and the basal ganglia. In animal models of temporal lobe epilepsy (TLE), seizure threshold is modulated to some extent by dopamine, with D1-receptors having a pro- and D2-receptors an anticonvulsant effect. We aimed to extend our previously reported results on decreased D2/D3 receptor binding in the lateral epileptogenic temporal lobe and to correlate them with demographic and seizure variables to gain a more comprehensive understanding of the underlying involvement of the dopaminergic system in the epileptogenesis of TLE. Methods To quantify D2/D3 receptor binding, we studied 21 patients with TLE and hippocampal sclero…

HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond

2018

International audience; Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control neuronal excitability and their dysfunction has been linked to epileptogenesis but few individuals with neurological disorders related to variants altering HCN channels have been reported so far. In 2014, we described five individuals with epileptic encephalopathy due to de novo HCN1 variants. To delineate HCN1-related disorders and investigate genotype-phenotype correlations further, we assembled a cohort of 33 unpublished patients with novel pathogenic or likely pathogenic variants: 19 probands carrying 14 different de novo mutations and four families with dominantly inherited variants segre…