Search results for "LET"
showing 10 items of 23489 documents
CMC is more than a measure of corticospinal tract integrity in acute stroke patients
2021
In healthy subjects, motor cortex activity and electromyographic (EMG) signals from contracting contralateral muscle show coherence in the beta (15-30 Hz) range. Corticomuscular coherence (CMC) is considered a sign of functional coupling between muscle and brain. Based on prior studies, CMC is altered in stroke, but functional significance of this finding has remained unclear. Here, we examined CMC in acute stroke patients and correlated the results with clinical outcome measures and corticospinal tract (CST) integrity estimated with diffusion tensor imaging (DTI). During isometric contraction of the extensor carpi radialis muscle, EMG and magnetoencephalographic oscillatory signals were re…
Combined effect of AAV-U7-induced dystrophin exon skipping and soluble activin Type IIB receptor in mdx mice.
2012
Adeno-associated virus (AAV)-U7-mediated skipping of dystrophin-exon-23 restores dystrophin expression and muscle function in the mdx mouse model of Duchenne muscular dystrophy. Soluble activin receptor IIB (sActRIIB-Fc) inhibits signaling of myostatin and homologous molecules and increases muscle mass and function of wild-type and mdx mice. We hypothesized that combined treatment with AAV-U7 and sActRIIB-Fc may synergistically improve mdx muscle function. Bioactivity of sActRIIB-Fc on skeletal muscle was first demonstrated in wild-type mice. In mdx mice we show that AAV-U7-mediated dystrophin restoration improved specific muscle force and resistance to eccentric contractions when applied a…
Hüftgelenkssonographie bei Skelettdysplasien mit metaphysärer Beteiligung
1988
Skeletal dysplasias with metaphyseal involvement show radiological changes which permit their classification. There are, however, changes in the cartilage which could be demonstrated by hip sonography in two children, one with Stickler's syndrome and the other with metaphyseal chondrodysplasia. The dangers of mis-diagnosis are discussed.
Zur Diagnostik der transitorischen Osteoporose der Hüfte und deren Darstellbarkeit in der MR-Tomographie
2008
Magnetic resonance (MR) imaging may distinguish transient osteoporosis of the hip from more severe hip diseases. 12 patients with transient osteoporosis of the hip underwent MR imaging. The initial and follow-up studies included T1- and T2-weighted images in coronal, transverse or sagittal planes. There were revealed 3 stages: diffuse-, focal-, and residual stage. This syndrome is characterized by hip pain, limping, and osteoporosis of the femoral head with preservation of the joint space. The clinical symptoms and abnormalities on MR images disappeared completely within 6-10 months.
The distribution of cartilage thickness in the knee-joints of old-aged individuals -- measurement by A-mode ultrasound.
1997
Abstract Objective. To provide data on the normal distribution of cartilage thickness in the knee joints of old-aged individuals. Design. The accuracy and reproducibility of cartilage thickness measurements were evaluated with A-mode ultrasound, and the cartilage thickness distribution was examined throughout both knee joints of nine individuals aged between 62 and 94 yr. Background. Data on the variation of cartilage thickness in the joint surfaces are relevant for the design of computer models of diathrodial joints and for surgical and arthroscopic procedures, particularly the calculation of cartilage material properties from indentation tests. Methods. A 12.5 MHz A-mode ultrasound transd…
Ultrastructure of Dural Lesions Produced in Lumbar Punctures
2014
During lumbar puncture, the insertion of a single-use, short-beveled spinal needle produces a “tent-like” effect. The dura-arachnoid lesions produced by this Quincke type of needles show a “crescent moon” shape resembling the letter “U” or “V” (similar to the lid of a can), with clean-cut edges. As the needle tip advances, the cut fragment is folded inwards, while all dural and arachnoid layers are entirely severed and the edges of the lesion are displaced inwardly. As soon as the spinal needle is withdrawn, the edges of the lesion tend to retract, owing to the viscoelastic properties of the affected dura mater.
A new tool to improve pedicle screw placement accuracy in navigated spine surgery: A monocentric study
2021
Objective Navigated instrumented spine surgery is burden by a low but significant screw mispositioning risks, respectively, for the 2D imaging system from 15 to 40% and, for the 3D imaging system, ranging from 4.1 to 11.5%. The primary objective of this study was to demonstrate the efficacy of a new "screw-like" tool in order to further decrease pedicle screws mispositioning rate during vertebral navigated spine surgery. Materials and methods Between January and June 2019 an initial case series of 18 patients were enrolled. All patients underwent a pedicle screw fixation, both in thoracic (Th10-Th12) and lumbosacral (L1-S1) spine, using O-arm (Medtronic Navigation, Louisville, Colorado) and…
The impact of multilevel surgery on functional abilities and participation in adolescents with cerebral palsy (CP)
2013
but not significant decrease in RT group. Timing of pKFSw, range of knee flexion and knee flexion velocity improved after surgery but tended to deteriorate over the years in either group. Discussionandconclusions:The results of thepresent study for the first time suggest that the influences of proximal RF release on DRFT effects on the knee joint are negligible. Two possible explanations shouldbe considered. First, thefindingsmaybe explainedby a permanent eliminationofRF functionon thekneeafterDRFT,which would be unaffected by proximal release and would underline the efficiency of DRFT. Secondly, surgery in the proximal part does not influence the distal part. This would represent a new imp…
Acupuncture in the treatment of temporomandibular disorders, facial pain, and postural neuromuscular disorders. Presentation of a clinical case
2021
Abstract Background and objectives Temporomandibular disorders have a multifactorial etiology and involve the masticatory muscles, temporomandibular joint and associated structures. Therefore, different treatments are proposed and used. The aim of this paper is the use of acupuncture to treat temporomandibular disorders and associated symptoms. This article presents a clinical case study of a 39-year-old patient who presented temporomandibular disorders and headache of muscular origin. Results After 10 acupuncture sessions, the results were highly satisfactory, with complete relief of headache pain and absence of joint disorders. These results suggest the efficacy of acupuncture in the symp…
Impaired geometric properties of tibia in older women with hip fracture history.
2007
This study evaluated side-to-side differences in tibial mineral mass and geometry in women with previous hip fracture sustained on average 3.5 years earlier. Both tibial mineral mass and geometry were found to be reduced in the fractured leg. INTRODUCTION: The purpose of this study was to evaluate side-to-side differences in tibial mineral mass and geometry after hip fracture and to assess the determinants of such differences. METHODS: Thirty-eight 60- to 85-year-old women with a previous hip fracture and 22 same-aged control women without fractures participated in the study. Bone characteristics of the distal tibia and tibial shaft of both legs were assessed using pQCT in order to compare …