Search results for "LIFE EXPECTANCY"
showing 10 items of 179 documents
Vascular aging in rodent models: contrasting mechanisms driving the female and male vascular senescence
2021
Increasing scientific interest has been directed to sex as a biological and decisive factor on several diseases. Several different mechanisms orchestrate vascular function, as well as vascular dysfunction in cardiovascular and metabolic diseases in males and females. Certain vascular sex differences are present throughout life, while others are more evident before the menopause, suggesting two important and correlated drivers: genetic and hormonal factors. With the increasing life expectancy and aging population, studies on aging-related diseases and aging-related physiological changes have steeply grown and, with them, the use of aging animal models. Mouse and rat models of aging, the most…
Palermo-2010 conference on biogerontology
2011
We, as the guest editors, are pleased to introduce this special issue of Biogerontology, which is the outcome from the 7th European Congress of Biogerontology, held from 14th to 17th October, 2010 in Palermo, Italy. The thematic aim of the Palermo-conference was to get an overview of the present state of research in the development of effective therapies to postpone or treat human ageing, focusing on predictive medicine and prevention of age-related diseases, immunosenescence, longevity, model systems, ageing and wellness, and vaccination in the elderly. Understanding the determinants of ageing in humans in relation to the living environment and the individual life history was the additiona…
Phenotypic Aspects of Longevity
2019
Centenarians are individuals who live over the average life span characteristic of their population. The growing number of old people worldwide makes it necessary to identify a good strategy to reach healthy ageing and avoid or delay age-related diseases. The longevity phenotype is the result of a positive combination between genetic, epigenetic, stochastic and lifestyle factors. So, the analysis of all the known parameters that can influence these single elements or their interaction can give new possible elements to delineate a sort of longevity signature. Starting from the easiest biomarkers as the haematochemical values and reaching the study of molecular and cellular components, as the…
Personal Savings and Investments in the Financial Market
2021
After 1998, CEE countries underwent an extensive reform process toward compliance with the new political, economic, and sociodemographic conditions. Reduced birth rate, increased life expectancy, and migration are challenges for PAYG public pension systems, which are directly dependent on the labor market and funding based on social security contributions paid by all earners and other wage earners. This chapter aims to give a socioeconomic perspective regarding personal saving, through various instruments offered by the banking and capital market, to supplement the financial resources of the elderly during retirement.
Temporal evolution of some mortality indicators: Application to Spanish data
2012
[EN] In Spain, as in other developed countries, significant changes in mortality patterns have occurred during the 20th and 21st centuries. One reflection of these changes is life expectancy, which has improved in this period, although the robustness of this indicator prevents these changes from being of the same order as those for the probability of death. If, moreover, we bear in mind that life expectancy offers no information as to whether this improvement is the same for different age groups, it is important and necessary to turn to other mortality indicators whose past and future evolution in Spain we are going to study. These indicators are applied to Spanish mortality data for the pe…
Converting retirement benefit into a life care annuity with graded benefits
2016
AbstractThis paper deals with life care annuities, i.e. bundled products comprising a life annuity and long-term care insurance. It aims to assess the cost of converting retirement benefit into a life care annuity with graded benefits using a pre-existing public pay-as-you-go pension scheme. With this objective in mind, we present an actuarial method based on array calculus for valuing this type of life care annuity. The health dynamics of the annuitant rely on a reversible illness-death multistate framework. The paper contains a numerical example in which mortality and disability assumptions are based on data from the USA and Australia, although this should be viewed simply as an illustrat…
Enhancing Joined-Up Government and Outcome-Based Performance Management through System Dynamics Modelling to Deal with Wicked Problems: the Case of S…
2015
The paper by Auping et al. (2015) focuses on the topic of societal ‘ageing’, that is, ‘a population process, caused by declining fertility and mortality rates, which manifests itself in the growing number of older persons in society’ (Huber, 2005). A broader definition frames societal ageing as a ‘demographic, structural, cultural and economic transformation resultant from the increase in the number and proportion of “older” people within society’ (Victor, 2005, p. 5). ‘Double societal ageing’ today characterizes most developed countries, which experience both an increase in the percentage of older people and in their life expectancy. In terms of public policy and finance, the relevance of …
Demographic aspects of aging
2021
Population aging is occurring in almost all developed countries, albeit with differences in timing and intensity. This unprecedented phenomenon is evident not only in the change in the population age structure, but also in the impressive increase in the average length of life. After describing past, current, and future population trends, this contribution presents theories explaining the reasons for this long-term process that is completely reshaping the age structure of the population. It also describes the inequalities in aging (focusing in particular on the differences by gender, education, and cause of death), and introduces some measures of the individual health and economic consequenc…
The Challenges in Moving from Ageing to Successful Longevity
2014
During the last decades survival has significantly improved and centenarians are becoming a fast-growing group of the population. Human life span is mainly dependent on environmental and genetic factors. Favourable modifications of lifestyle factors (e.g. physical activity, diet and not smoking) and healthcare (e.g. effective vascular disease prevention) have also increased human life span. Genetic factors contribute to the variation of human life span by around 25%, which is believed to be more profound after 85 years of age. It is likely that multiple factors influence life span and we need answers to questions such as: 1) What does it take to reach 100?, 2) Do centenarians have better he…
Do epigenetic clocks provide explanations for sex differences in lifespan? A cross-sectional twin study
2021
ABSTRACTBackgroundThe sex gap in life expectancy has been narrowing in Finland over the past four to five decades; however, on average, women still live longer than men. Epigenetic clocks are markers for biological aging that predict lifespan. In this study, we examined the mediating role of lifestyle factors on the association between sex and biological aging in younger and older adults.MethodsOur sample included same-sex younger and older twins (21-42-y, n = 1110; 50-76-y, n = 763) and younger opposite-sex twins (21-30-y, n = 302). Blood-based DNA methylation (DNAm) was used to compute epigenetic age acceleration by four epigenetic clocks as a measure of biological aging. Path modelling w…