Search results for "LIOP"
showing 10 items of 1268 documents
Oppimisen laatu ja opiskelun joustavuus: ohjauksellisen pedagogiikan ydin
2009
Blended learning Jyväskylän yliopiston avoimessa yliopistossa kuvataan blended learningin ajatusta käsitteellä ohjauksellinen pedagogiikka. Se edustaa pedagogisia ratkaisuja, jotka tukevat opiskelijan aktiivista ja yksilöllistä oppimista sekä tarjoavat joustavia opiskelumahdollisuuksia. Toisaalta sillä ymmärretään opettajan pedagogista taitoa organisoida opetus siten, että opiskelijan oppimispolku olisi eheä, mielekäs ja tuottaisi hyviä oppimistuloksia.
Oulun yliopiston arviointia – Kotkan silmästä siiville
2005
Yliopistojen arviointiin ja laadunvarmistukseen on viime vuosikymmeninä kiinnitetty runsaasti huomiota eurooppalaisessa korkeakoulupolitiikassa. Varsinkin Bolognan prosessi on kiihdyttänyt keskustelua ja saanut korkeakoulujen arvioijat miettimään keinoja yhteisten laadunvarmistusjärjestelmien löytämiseksi. Myös kriittisiä ääniä uudistusvaatimuksia kohtaan on esitetty. Suomessa yliopistotason arvioinnit ovat yleistyneet 1990-luvun alusta lähtien. Jokaisessa suomalaisessa yliopistossa on toteutettu kokonaisarviointi, jonka keskeisenä osana on usein ollut yliopiston itsearviointi. Aikuiskasvatuksen teemanumero käsittelee Oulun yliopiston opetuksen arviointityötä ”Kotkan silmässä” kahdesta eri …
A high-throughput genome-wide siRNA screen for ciliogenesis identifies new ciliary functional components and ciliopathy genes.
2015
Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe the first whole genome siRNA-based reverse genetics screen for defects in biogenesis and/or maintenance of the primary cilium, obtaining a global resource for investigation and interventions into the processes that are critical for the ciliary system. In total, we identified 83 candidate ciliogenesis and ciliopathy genes, including 15 components of the ubiquitin-proteasome system. The validated hits also include 12 encoding G-protein-coupled receptors, and three encoding pre-mRNA processing factors (PRPF6, PRPF8 and PRPF31) mutated in autosomal dominant retinitis pigmentosa. Com…
Novel mutations including deletions of the entire OFD1 gene in 30 families with type 1 orofaciodigital syndrome : a study of the extensive clinical v…
2012
OFD1, now recognized as a ciliopathy, is characterized by malformations of the face, oral cavity and digits, and is transmitted as an X-linked condition with lethality in males. Mutations in OFD1 also cause X-linked Joubert syndrome (JBTS10) and Simpson-Golabi-Behmel syndrome type 2 (SGBS2). We have studied 55 sporadic and six familial cases of suspected OFD1. Comprehensive mutation analysis in OFD1 revealed mutations in 37 female patients from 30 families; 22 mutations have not been previously described including two heterozygous deletions spanning OFD1 and neighbouring genes. Analysis of clinical findings in patients with mutations revealed that oral features are the most reliable diagnos…
Identification of novel interaction partners for Vlgr1b/GPR98 - a key component of the periciliary Usher syndrome protein network in photoreceptor ce…
2012
The human Usher syndrome (USH) is the most common form of combined hereditary deaf-blindness. Three clinical subtypes (USH1-3) are differentiated based on severity, age of onset and progression of the symptoms. Mutations in the GPR98 gene encoding the USH2C protein Vlgr1b or GPR98 cause USH2, the most common form of USH. The G-protein coupled receptor Vlgr1b was previously identified as a component of the periciliary USH protein network, crucial for ciliary cargo transport in photoreceptors. Nonetheless, the exact role of Vlgr1b in this and other cellular processes remains to be elucidated. To learn more about its involvement in cellular functions we searched for novel interaction partners …
A mobile game as a support tool for children with severe difficulties in reading and spelling
2020
We used a randomized controlled trial to investigate if a mobile game, GraphoLearn (GL), could effectively support the learning of first graders (N = 70), who have severe difficulties in reading and spelling. We studied the effects of two versions of the game: GL Reading, which focused on training letter-sound correspondence and word reading; and GL Spelling, which included additional training in phonological skills and spelling. During the spring of first grade, the children trained with tablet computers which they could carry with them during the six-week intervention. The average exposure time to training was 5 hr 44 min. The results revealed no differences in the development of reading …