Search results for "LIOP"
showing 10 items of 1268 documents
2021
Primary cilia are sensory organelles vital for developmental and physiological processes. Their dysfunction causes a range of phenotypes including retinopathies. Although primary cilia have been described in the retinal pigment epithelium (RPE), little is known about their contribution to biological processes within this tissue. Ciliary proteins are increasingly being identified in non-ciliary locations and might carry out additional functions, disruption of which possibly contributes to pathology. The RPE is essential for maintaining photoreceptor cells and visual function. We demonstrate that upon loss of Bbs8, predominantly thought to be a ciliary gene, the RPE shows changes in gene and …
Effect of two prophylaxis methods on adherence of Streptococcus mutans to microfilled composite resin and giomer surfaces
2010
Objectives: Surface attributes of a restoration play an important role in adherence of plaque bacteria. Prophylaxis methods may be involved in modification of or damaging the restoration surface. The aim of the present study was to evaluate the effect of two prophylaxis methods on adherence of Streptococcus mutans to the surface of two restorative materials. Study design: A total of 60 specimens were prepared from each material; a microfilled composite resin (HelioProgress) and a giomer (Beautifil II). For each material, the specimens were randomly divided into three groups (n=20). Group 1: no prophylaxis treatment (control); Group 2: prophylaxis with pumice and rubber cup; Group 3: prophyl…
Usher Syndrome Protein Network Functions in the Retina and their Relation to Other Retinal Ciliopathies
2014
The human Usher syndrome (USH) is the most frequent cause of combined hereditary deaf-blindness. USH is genetically and clinically heterogeneous: 15 chromosomal loci assigned to 3 clinical types, USH1-3. All USH1 and 2 proteins are organized into protein networks by the scaffold proteins harmonin (USH1C), whirlin (USH2D) and SANS (USH1G). This has contributed essentially to our current understanding of the USH protein function in the eye and the ear and explains why defects in proteins of different families cause very similar phenotypes. Ongoing in depth analyses of USH protein networks in the eye indicated cytoskeletal functions as well as roles in molecular transport processes and ciliary…
Gene-based treatment options for Usher type 1C by translational read-through of a nonsense mutation
2012
The Usher syndrome (USH) is the most frequent cause of inherited combined deaf-blindness. The ciliopathy is clinically and genetically heterogeneous, assigned to three clinical USH types of which the most severe type is USH1. The USH1C gene encodes the PDZ containing scaffold protein harmonin which is expressed in form of numerous alternatively spliced variants. Hamonin binds directly to all USH1/2 proteins and is a key organizer of USH protein networks in photoreceptor cells. So far no effective treatment for the ophthalmic component of USH exists. Translational read-through was introduced as an innovative therapy option for several non-ocular diseases caused by nonsense mutations leading …
Suomessa asuvien yläkouluikäisten maahanmuuttajanuorten seksuaaliterveystiedot
2011
Opinnäytetyön tarkoituksena on selvittää millainen seksuaaliterveystietämys yläkouluikäisillä maahanmuuttajanuorilla on. Tutkimuksessa tarkastellaan iän, sukupuolen, luokka-asteen, maassaoloajan ja kouluvuosien yhteyttä seksuaaliterveystietoihin. Tutkimuksessa selvitetään myös millaista seksuaaliterveystietoa maahanmuuttajanuoret kokevat tarvitsevansa ja miten tämä on suhteessa heidän menestykseensä tietokysymyksissä. Lisäksi selvitetään maahanmuuttajanuorten kokemuksia koulun seksuaaliopetuksesta. Tutkimuksen aineisto kerättiin kyselylomakkeella, joka perustui suomalaisnuorille aiemmin tehdyn seksuaaliterveystietokyselyn kysymyksiin. Tutkimukseen osallistui viisi yläkoulua eri puolilta Suo…
Lessons learned from a community engagement initiative within Irish higher education
2018
This paper focuses on a community–university partnership built around a programme of study co-created by residents of a disadvantaged community and situated, for the most part, within that community. The aim of this paper is to share lessons learned from this community engagement initiative, as identified through a research study which ran concurrent to the programme. The study involved 41 interviews (18 individual interviews and 23 focus groups) over a two-year period with 28 participants. Participants included students, lecturers and community and university stakeholders. The finding section focuses on the characteristics of the initiative which allowed it to positively impact those invol…
Orobanche australis Moris ex Bertol. the correct name for O. thapsoides Lojac. (Orobanchaceae)
2022
The taxonomic relationships between Orobanche australis and O. thapsoides are analyzed through the study of the original material. These species are also compared with other morphologically similar ones occurring in the Mediterranean (O. canescens, O. pubescens, O. palaestina, O. amethystea). The lectotype of O. palaestina is designated. From the comparison of these taxa it is evident that O. australis and O. thapsoides refer to the same taxon, to which the name O. australis must be given by priority. The distribution of this species includes Sardinia, Sicily, Peninsular Italy and Southern France. It grows on pastures from the sea level to about 1000 m of altitude, host of Asteraceae. An id…
New records of the genus Orobanche L. (Orobanchaceae) to the Tunisian flora with lectotypification of the name O. rapum-genistae Thuill.
2023
Based on several field surveys and on the study of original material, we have identified three new species of Orobanche L. s.s. (Orobanchaceae) new to the flora of Tunisia. Orobanche alba Willd., O. calendulae Pomel, and O. gracilis Sm. are reported as new for the country, and the occurrence of O. rapum-genistae Thuill. is confirmed. The lectotypification of O. rapum-genistae is here proposed with a specimen housed in Genève (G). The geographical distribution of the four taxa in Tunisia is given, and details of habitats and hosts are provided. Altogether, the genus Orobanche in Tunisia now includes 18 species; a dichotomous key is proposed to facilitate the identification of these taxa.
Searching for the competitive ability of the alien seagrass Halophila stipulacea with the autochthonous species Cymodocea nodosa
2023
The tropical seagrass Halophila stipulacea (Forsskål) Ascherson, 1867 entered in the Mediterranean Sea through the Suez Canal more than 100 years ago. In coastal-marine ecosystems the spatial niche of H. stipulacea is often overlapped with that of native Mediterranean Sea seagrasses and therefore it might out-compete them. Aiming to better understand its invasiveness potential, we monitored a Southern Mediterranean shallow coastal-marine water habitat from August 2010 to August 2011, where H. stipulacea co-occurred with the native seagrass Cymodocea nodosa (Ucria) Ascherson, 1870. Besides, the year-round dynamics of H. stipulacea was also monitored in four periods. To test the hypothesis th…