Search results for "LIST"

A knowledge-based master model approach exemplified with jet engine structural design

2017

Successful product development requires the consideration of multiple engineering disciplines and the quantification of tradeoffs among conflicting objectives from the very early design phases. The single-largest challenge to do so is the lack of detailed design information. A possible remedy of this issue is knowledge-based engineering. This paper presents a knowledge-based master model approach that enables the management of concurrent design and analysis models within different engineering disciplines in relation to the same governing product definition. The approach is exemplified on an early phase structural design of a turbo-fan jet engine. The model allows geometric-, structural mech…

The probabilistic pickup-and-delivery travelling salesman problem

2019

Abstract Transportation problems are essential in commercial logistics and have been widely studied in the literature during the last decades. Many of them consist in designing routes for vehicles to move commodities between locations. This article approaches a pickup-and-delivery single-vehicle routing problem where there is susceptibility to uncertainty in customer requests. The probability distributions of the requests are assumed to be known, and the objective is to design an a priori route with minimum expected length. The problem has already been approached in the literature, but through a heuristic method. This article proposes the first exact approach to the problem. Two mathematica…

Graph-theoretical derivation of brain structural connectivity

2020

Brain connectivity at the single neuron level can provide fundamental insights into how information is integrated and propagated within and between brain regions. However, it is almost impossible to adequately study this problem experimentally and, despite intense efforts in the field, no mathematical description has been obtained so far. Here, we present a mathematical framework based on a graph-theoretical approach that, starting from experimental data obtained from a few small subsets of neurons, can quantitatively explain and predict the corresponding full network properties. This model also changes the paradigm with which large-scale model networks can be built, from using probabilisti…

Identification of Objects Based on Generalized Amplitude-Phase Images Statistical Models

2017

The article presents the dynamical objects identification technology based on statistical models of amplitude-phase images (APIm) – multidimensional data arrays (semantic models) and statistical correlation analysis methods using the generalized discrete Hilbert transforms (DHT) – 2D Hilbert (Foucault) isotropic (HTI), anisotropic (HTA) and total transforms – AP-analysis (APA) to calculate the APIm. The identified objects are modeled with 3D airplanes templates rotated in space around the center of Cartesian coordinate system. The DHT domain system of coordinates displaying the plane projections (2D flat images) remains to be space-invariant. That causes the anisotropic properties of APIm a…

El obispo Vicente Roca de la Serna y su sepulcro en san Juan de la Ribera, obra del maestro marmolista Juan Bautista Semería

2016

Análisis de la siniestralidad en ciclistas 2008-2013

2016

[ES] Los accidentes con víctimas ciclistas han sufrido un continuo ascenso en los últimos años. A fin de conocer cuáles son las características tanto del ciclista implicado en un accidente, como de las circunstancias en las que éste se ha producido, se ha realizado un estudio en el que se analiza la siniestralidad de los ciclistas registrada en España en el período comprendido entre 2008 a 2013. La investigación se ha realizado a partir de la base de datos de accidentes oficial de la Dirección General de Tráfico (base ARENA). En total se han analizado 25.439 accidentes con ciclistas implicados y 24.520 víctimas ciclistas. Los principales resultados de este estudio muestran que el número de …

Anti-Listeria activity of lactic acid bacteria in two traditional Sicilian cheeses

2017

<em>Listeria monocytogenes</em> is a pathogen frequently found in dairy products, and its growth is difficult to control. Bacteriocinlike inhibitory substances (BLIS), produced by lactic acid bacteria (LAB), having proven <em>in vitro</em> anti-<em>Listeria</em> activity, could provide an innovative approach to control <em>L. monocytogenes</em>; however, this application needs to be evaluated <em>in vivo</em>. In this study, twenty LAB strains isolated from different Sicilian dairy environments were tested for control of growth of <em>L. monocytogenes</em> in three different experimental trials. First, raw and UHT milk …

Environmental radiation alters the gut microbiome of the bank vole Myodes glareolus.

2018

International audience; Gut microbiota composition depends on many factors, although the impact of environmental pollution is largely unknown. We used amplicon sequencing of bacterial 16S rRNA genes to quantify whether anthropogenic radionuclides at Chernobyl (Ukraine) impact the gut microbiome of the bank vole Myodes glareolus. Exposure to elevated levels of environmental radionuclides had no detectable effect on the gut community richness but was associated with an almost twofold increase in the Firmicutes:Bacteroidetes ratio. Animals inhabiting uncontaminated areas had remarkably similar gut communities irrespective of their proximity to the nuclear power plant. Hence, samples could be c…

Indicaxanthin from Opuntia Ficus Indica (L. Mill) impairs melanoma cell proliferation, invasiveness, and tumor progression.

2018

Abstract Background: A strong, reciprocal crosstalk between inflammation and melanoma has rigorously been demonstrated in recent years, showing how crucial is a pro-inflammatory microenvironment to drive therapy resistance and metastasis. Purpose: We investigated on the effects of Indicaxanthin, a novel, anti-inflammatory and bioavailable phytochemical from Opuntia Ficus Indica fruits, against human melanoma both in vitro and in vivo. Study Design and Methods: The effects of indicaxanthin were evaluated against the proliferation of A375 human melanoma cell line and in a mice model of cutaneous melanoma. Cell proliferation was assessed by MTT assay, apoptosis by Annexin V-Fluorescein Isothio…

Anakinra drug retention rate and predictive factors of long-term response in systemic juvenile idiopathic arthritis and adult onset still disease

2019

Background and Objective: Only a few studies have reported long-term efficacy of interleukin (IL)-1 inhibition in systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still disease (AOSD). Herein we report on the effectiveness of anakinra (ANA), expressed in terms of drug retention rate (DRR), and evaluate the predictive factors of drug survival in a cohort of patients with sJIA and AOSD. Patients and Methods: This is a multicenter study reviewing retrospectively the medical records from 61 patients with sJIA and 76 with AOSD, all treated with ANA in 25 Italian tertiary referral centers. Results: The cumulative retention rate of ANA at 12-, 24-, 48-, and 60-month of follow-up was 7…