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showing 10 items of 4869 documents

Spectroscopic axonal damage of the right locus coeruleus relates to selective attention impairment in early stage relapsing-remitting multiple sclero…

2003

Summary Lower levels of N-acetylaspartate (NAA), a marker of axonal damage, have been found in the normal-appearing white matter (NAWM) of relapsing-remitting multiple sclerosis (RRMS) patients with low physical disability. However, its relation to the clinical status of these patients remains unclear. We explored the association between NAA levels [normalized to creatine (Cr), NAA/Cr] and a cognitive feature that is not measured by the standard scales that address functional disability [e.g. Expanded Disability Scale Score (EDSS)] in early RRMS. Given that a considerable number of RRMS patients present attentional dysfunction early in the disease and assuming a functional-anatomical orient…

AdultMalemedicine.medical_specialtyMagnetic Resonance SpectroscopyAudiologyLateralization of brain functionDichotic Listening TestsCentral nervous system diseaseWhite matterDisability EvaluationMultiple Sclerosis Relapsing-RemittingmedicineHumansAttentionAnalysis of VarianceAspartic AcidDichotic listeningMultiple sclerosismedicine.diseaseAxonsmedicine.anatomical_structurenervous systemLinear ModelsLocus coeruleusFemaleLocus CoeruleusNeurology (clinical)Analysis of varianceCognition DisordersPsychologyNeuroscienceReticular activating systemBiomarkersBrain
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Focal therapy in localised prostate cancer: Real-world urological perspective explored in a cross-sectional European survey

2018

Introduction: The urological community's opinion over focal therapy (FT) for prostate cancer (PCa) has never been assessed. Our aim was to investigate the current opinion on FT in the European urological community. Methods: A 25 -item questionnaire was devised according to the Cherries checklist and distributed through SurveyMonkey using a web link from November 2016 to October 2017. After a pilot validation (n=40 urologists), the survey was sent through EAU and 9 other national European urological societies mailing list. Twitter was also used. Results: We received 484 replies from 51 countries. Almost half (44.8%, n=217) stated FT would represent a step forward, and 52.0% (n=252) would sug…

AdultMalemedicine.medical_specialtyMultivariate analysisUrology030232 urology & nephrologyClinical practiceClinical practice; European Association of Urology; Focal therapy; Prostate cancer; Survey; Young Academic Urologists03 medical and health sciencesProstate cancer0302 clinical medicineFocal therapySurveys and QuestionnairesmedicineHumansIn patientSurveyProstate cancerbusiness.industryProstatic NeoplasmsNegative opinionMiddle AgedUrology & NephrologyPrognosismedicine.diseaseChecklistEuropeFocal therapyClinical PracticeEuropean Association of UrologyYoung Academic UrologistsCross-Sectional StudiesOncology030220 oncology & carcinogenesisFamily medicineEAU-YAU Prostate Cancer Working Partybusiness1112 Oncology And CarcinogenesisFollow-Up StudiesUrologic Oncology: Seminars and Original Investigations
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Time expenditure in patient-related care provided by specialist palliative care nurses in a community hospice service

2004

Although the importance of specialist palliative care in home care programmes for terminally ill patients is well known, German community hospice services did not begin to employ nurses who had specialized in palliative care until the early 1990s. The general tasks of these nurses are sufficiently well defined, but no comprehensive data of their daily workload are available in Germany to date. The present article examines time expenditure in direct patient-related care at the community-based hospice service in Mainz, Germany, by analysing time registration sheets concerning 351 patients who received care from January 2000 until December 2002. Fifty-five per cent of care time spent on each …

AdultMalemedicine.medical_specialtyPalliative careAdolescentWorkloadMinor (academic)Nurse's RoleTime03 medical and health sciences0302 clinical medicineNursing030502 gerontologyGermanyIntensive caremedicineHumansIn patientSpecialist palliative careAgedAged 80 and overService (business)business.industryPalliative CarePatient contactWorkloadGeneral MedicineMiddle AgedHospice CareAnesthesiology and Pain Medicine030220 oncology & carcinogenesisFamily medicineFemaleNursing CareNurse-Patient Relations0305 other medical sciencebusinessDelivery of Health CarePalliative Medicine
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End-of-life situations in cardiology: a qualitative study of physicians' and nurses' experience in a large university hospital.

2018

IF 2.335 (2-year Impact Factor); International audience; Background: rofessional societies call for integration of end-of-life discussions early in the trajectory of heart failure, yet it remains unclear where current practices stand in relation to these recommendations. We sought to describe the perceptions and attitudes of caregivers in cardiology regarding end-of-life situations.Methods: e performed a qualitative study using semi-directive interviews in the cardiology department of a university teaching hospital in France. Physicians, nurses and nurses’ aides working full-time in the department at the time of the study were eligible. Participants were asked to describe how they experienc…

AdultMalemedicine.medical_specialtyPalliative careAttitude of Health Personnellcsh:Special situations and conditionsClinical Decision-MakingPsychological interventionCardiologyContext (language use)Legislation030204 cardiovascular system & hematologyNursing Staff Hospital03 medical and health sciences0302 clinical medicine[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemProfessional-Family RelationsInternal medicinemedicineHumans030212 general & internal medicineQualitative ResearchHeart FailureTerminal Carelcsh:RC952-1245Palliative CareGeneral MedicineProfessional-Patient RelationsMiddle Aged[SDV.ETH] Life Sciences [q-bio]/Ethics[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system[SDV.ETH]Life Sciences [q-bio]/Ethics3. Good healthDistressHospitalistsCardiologyDisease ProgressionProfessional associationFemaleInterdisciplinary CommunicationCardiology Service HospitalFranceThematic analysisPsychologyAdvance DirectivesQualitative researchResearch ArticleEnd-of-lifeBMC palliative care
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The Applicability of a Checklist for the Diagnosis and Treatment of Exocrine Pancreatic Insufficiency: Results of the Italian Exocrine Pancreatic Ins…

2020

Objective To evaluate a rapid checklist capable of identifying exocrine pancreatic insufficiency in outpatients. Methods Prospective observational study of a multicenter cohort. Results One hundred and two patients were enrolled; 61.8% of the patients had medically-treated benign or malignant pancreatic disease, and 38.2% had a pancreatic resection. Visual examination of the feces was evaluated in 84 patients and it was related to steatorrhea in 51 patients (50.0%). Receiver operating characteristic curves were evaluated for each symptom or clinical sign and four of them (ie, increase in daily bowel movements, number of bowel movements, fatty stools, >10% weight loss) had a satisfactory …

AdultMalemedicine.medical_specialtyPancreatic diseaseSettore MED/09 - Medicina InternaEndocrinology Diabetes and MetabolismPancreatic Extractsmedicine.medical_treatmentGastroenterology03 medical and health sciences0302 clinical medicineEndocrinologyWeight lossInternal medicineOutpatientsInternal MedicinemedicineHumansEnzyme Replacement TherapyProspective StudiesRegistriesExocrine pancreatic insufficiencyPancreas enzymeAgedHepatologybusiness.industrydigestive oral and skin physiologyFeces analysisexocrine pancreatic insufficiency fecal elastase-1 maldigestion pancreatic diseases steatorrhea.Middle Agedmedicine.diseaseChecklistSteatorrheaPancreatic Function TestsItalyROC Curve030220 oncology & carcinogenesisPancreatectomyExocrine Pancreatic InsufficiencyFemale030211 gastroenterology & hepatologymedicine.symptombusiness
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Soluble CD14 monocyte antigen in suction blister fluid and serum of patients with psoriasis.

1993

The purpose of this study was to measure soluble CD14 (sCD14) molecules in the skin and in serum of patients with psoriasis. CD14 is a newly discovered cell surface marker on monocytes that is shed after cell activation. The following procedures were used: suction blisters were raised over the abdominal skin of 9 healthy control individuals and 8 patients with psoriasis. Serum of 17 healthy controls and 17 patients with psoriasis was collected. sCD14 was determined in suction blister fluid and serum by the ELISA technique. The clinical status of psoriasis was rated by the psoriasis area and severity index (PASI score). We found that sCD14 levels in suction blisters of healthy skin (1,050 +/…

AdultMalemedicine.medical_specialtyPathologyAdolescentLipopolysaccharide ReceptorsAntigens Differentiation MyelomonocyticDermatologySuctionGastroenterologySeverity of Illness IndexMonocytesBlisterAntigenPsoriasis Area and Severity IndexAntigens CDPsoriasisImmunopathologyInternal medicinemedicineHumansPsoriasisAgedintegumentary systembusiness.industryMonocyteBlistersMiddle Agedmedicine.diseaseSuction blisterBody Fluidsmedicine.anatomical_structureFemalemedicine.symptomCell activationbusinessDermatology (Basel, Switzerland)
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Clinically atypical spitzoid lesions: semi-quantitative histologic index correlation with dermoscopic scores (ABCD rule, 7-point checklist and patter…

2014

Background The distinction of Spitz and Reed nevi with atypical features from melanoma may be a difficult task. In these cases, the dermoscopic scores could bring variable results and not always correlate with the histologic diagnosis. Objective The aim of this study was to compare the histopathologic and dermoscopic findings in a cohort of clinically atypical Spitz and Reed nevi. Methods We retrospectively reviewed 19 cases of atypical Spitz and Reed nevi from our files. We constructed a new semi-quantitative histologic index (HI) based on the reproducible microscopic features, and correlated it with two dermoscopic scores: ABCD and 7-point checklist, as well as with the predominant dermos…

AdultMalemedicine.medical_specialtyPathologySkin NeoplasmsAdolescentPattern analysisDermoscopyDermatologyDiagnosis DifferentialCorrelationYoung AdultNevus Epithelioid and Spindle CellmedicineHumansNevusChildMelanomaRetrospective Studiesbusiness.industryRetrospective cohort studymedicine.diseaseDermatologyChecklistChecklistAbcd ruleInfectious DiseasesChild PreschoolFemalebusinessSemi quantitativeJournal of the European Academy of Dermatology and Venereology
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What Predicts Outcome, Response, and Drop-out in CBT of Depressive Adults? A Naturalistic Study

2012

Background: The efficacy of CBT for unipolar depressive disorders is well established, yet not all patients improve or tolerate treatment. Aims: To identify factors associated with symptomatic outcome, response, and drop-out in depressive patients under naturalistic CBT. Method: 193 patients with major depression or dysthymia were tested. Sociodemographic and clinical variables were entered as predictors in hierarchical regression analyses. Results: A higher degree of pretreatment depression, early improvement, and completion of therapy were identified as predictors for symptomatic change and response. Drop-out was predicted by concurrent personality disorder, less positive outcome expectan…

AdultMalemedicine.medical_specialtyPatient Dropoutsgenetic structuresmedia_common.quotation_subjectCultureMEDLINEStandardized testComorbidityPersonality Disordersbehavioral disciplines and activitiesNaturalistic observationGermanyHealth caremedicineHumansPersonalityPsychiatryDepression (differential diagnoses)media_commonDepressive Disorder MajorMotivationCognitive Behavioral Therapybusiness.industryMultilevel modelProfessional-Patient RelationsGeneral MedicineMiddle AgedPrognosismedicine.diseaseComorbidityClinical PsychologyOutcome and Process Assessment Health Carenervous systemFemaleDysthymic DisorderPsychologybusinesspsychological phenomena and processesClinical psychologyBehavioural and Cognitive Psychotherapy
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Prognosis of Patients Listed for a Heart Transplant During the Pretransplant Period: Does Diabetes Matter?

2013

Whether patients with advanced heart failure and diabetes mellitus (DM) should be listed for heart transplantation (HTx) remains controversial due to conflicting findings regarding their post-HTx survival (1–3). We studied HTx candidates with and without DM during the pre-HTx period, examining multiple waiting list outcomes. Patients were enrolled in the Waiting for a New Heart Study, a multisite observational study of 318 adult (≥18 years of age) patients (aged 53 ± 11 years; 18% female) who were newly listed for HTx with Eurotransplant between April 2005 and December 2006 (4). Informed consent and ethics approval were obtained (4). Characteristics at the time of listing included age, DM, …

AdultMalemedicine.medical_specialtyPediatricsEndocrinology Diabetes and Metabolismmedicine.medical_treatmentTreatment outcomeInformed consentDiabetes mellitusDiabetes MellitusInternal MedicinemedicineHumansOnline Letters: ObservationsHeart FailureAdvanced and Specialized NursingHeart transplantationbusiness.industryMiddle AgedPrognosismedicine.diseaseSurgeryTreatment OutcomeWaiting listHeart failureHeart TransplantationFemaleObservational studybusinessDiabetes Care
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High Prevalence of Mental Disorders and Emotional Distress in Patients with Chronic Spontaneous Urticaria

2011

Quality of life, which is impaired in patients with chronic spontaneous urticaria (CSU), is influenced by comorbid mental disorders. The aim of this study was to assess the prevalence and spectrum of mental disorders and to determine levels of emotional distress in patients with CSU. One hundred patients with CSU were investigated for mental disorders (by specialized diagnostic interviews and psychometric instruments), levels of emotional distress (by the Global Severity Index of the Symptom Check List; SCL-90R GSI) and underlying causes of their urticaria (by dermatological assessment). Forty-eight percent of patients with CSU were diagnosed with one or more psychosomatic disorders; most c…

AdultMalemedicine.medical_specialtyPsychometricsUrticariaPsychometricsEmotionsComorbidityDermatologyInterviews as TopicQuality of life (healthcare)Prevalence of mental disordersPredictive Value of TestsRisk FactorsGermanyPrevalencemedicineHumansPsychiatryDepression (differential diagnoses)Phobiasbusiness.industryMental DisordersGeneral Medicinemedicine.diseaseComorbidityChecklistClinical trialChronic DiseaseQuality of LifeAnxietyFemalemedicine.symptombusinessStress PsychologicalActa Dermato Venereologica
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