Search results for "LIST"

The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8 + T cells

2013

Robust cytotoxic CD8 + T-cell response is important for immunity to intracellular pathogens. Here, we show that the transcription factor IFN Regulatory Factor 4 (IRF4) is crucial for the protective CD8 + T-cell response to the intracellular bacterium Listeria monocytogenes . IRF4-deficient ( Irf4 −/− ) mice could not clear L. monocytogenes infection and generated decreased numbers of L. monocytogenes -specific CD8 + T cells with impaired effector phenotype and function. Transfer of wild-type CD8 + T cells into Irf4 −/− mice improved bacterial clearance, suggesting an intrinsic defect of CD8 + T cells in Irf4 −/− mice. Following transfer into wild-type recipients, Irf4 −/− CD8 + T cells bec…

Geopolitical aspects of prudery, or Stalin as the breeches maker: political censorship and puritan censorship in the USSR

2015

Due leggi recentemente discusse al parlamento russo, tese a punire le oscenità anche nelle opere letterarie e l'uso “ingiustificato” di parole straniere, sono un'occasione per indagare il rapporto tra censura politica e censura moralistica, di cui è ben nota l'importanza nel periodo stalinista e poststalinista, ma il cui legame è stato raramente considerato.Se per quanto riguarda la censura politica non resta molto da scoprire, lo straordinario moralismo del regime sovietico a partire dagli anni Trenta contiene elementi di contraddizione tanto con tensioni verso la liberazione dei costumi presenti nel discorso bolscevico del periodo precedente quanto con la retorica dell'”uomo nuovo” che si…

Il realismo socialista e il GULag: estetica normativa e censura

2009

La censura sovietica (come dimostrato dall'analisi delle due versioni del Secondo giorno di Erenburg) temeva i nomi più che i concetti. Allo stesso modo, la sorte del volume sul Belomorkanal dimostra che a imporre l'estetica del realismo socialista contro le avanguardie possono essere state ragioni censorie.

The Process-inducing Activity of Transmembrane Agrin Requires Follistatin-like Domains

2009

Clustering or overexpression of the transmembrane form of the extracellular matrix proteoglycan agrin in neurons results in the formation of numerous highly motile filopodia-like processes extending from axons and dendrites. Here we show that similar processes can be induced by overexpression of transmembrane-agrin in several non-neuronal cell lines. Mapping of the process-inducing activity in neurons and non-neuronal cells demonstrates that the cytoplasmic part of transmembrane agrin is dispensable and that the extracellular region is necessary for process formation. Site-directed mutagenesis reveals an essential role for the loop between beta-sheets 3 and 4 within the Kazal subdomain of t…

El centro, coartada de la confusión

2003

Lissencephalic syndromes: brain and beyond

2009

Lissencephaly has been long maintained a malformation involving only the brain. Classic lissencephaly includes agyria and pachygyria and it is the most severe form of malformations derived from abnormal neuronal migration. It is defined as a smooth or nearly smooth cerebral surface with absence of normal sulci and gyria. It encompasses a group of syndromes which show many different clinical conditions. Four groups are actually distinguished: classic lissencephaly variants, other lissencephalies including forms with unknown pathogenesis, microlissencephaly spectrum and Cobblestone cortical malformations. Several genes and proteins are involved in this syndromic spectrum and each year new mol…

A method for the probabilistic analysis of nonlinear systems

1995

Abstract The probabilistic description of the response of a nonlinear system driven by stochastic processes is usually treated by means of evaluation of statistical moments and cumulants of the response. A different kind of approach, by means of new quantities here called Taylor moments, is proposed. The latter are the coefficients of the Taylor expansion of the probability density function and the moments of the characteristic function too. Dual quantities with respect to the statistical cumulants, here called Taylor cumulants, are also introduced. Along with the basic scheme of the method some illustrative examples are analysed in detail. The examples show that the proposed method is an a…

The contribution of the E+M / PESI Projects to the vascular flora of the Mediterranean islands

2011

Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics

2018

Abstract Multidrug-resistant bacterial infections are a global health threat. Nanoparticles are thus investigated as novel antibacterial agents for clinical practice, including wound dressings and implants. We report that nanoparticles' bactericidal activity strongly depends on their physical binding to pathogens, including multidrug-resistant primary clinical isolates, such as Staphylococcus aureus , Klebsiella pneumoniae or Enterococcus faecalis . Using controllable nanoparticle models, we found that nanoparticle-pathogen complex formation was enhanced by small nanoparticle size rather than material or charge, and was prevented by 'stealth' modifications. Nanoparticles seem to preferentia…

Combination of phenolic acids and essential oils against Listeria monocytogenes

2015

Abstract Listeria monocytogenes is a psychrotrophic pathogen widely distributed in meat processing plants. Listeriosis presents very low morbidity, but very high mortality rates. Several outbreaks involving this bacterium have been reported due to the consumption of refrigerated meat and dairy products. The objective of the present study was to evaluate the in vitro antimicrobial activity of 10 phenolic acids (PAs) and 4 essential oil compounds (EOCs) as natural alternatives to control L. monocytogenes growth. The minimum inhibitory concentration (MIC) of all natural compounds was determined at pH 5, 6 and 7. The 4 most potent PAs (ρ-hydroxybenzoic acid, ferulic acid, o-coumaric acid and sy…