Search results for "LK"
showing 10 items of 8438 documents
Coordination abilities of N-methyl alkylaminomethane-1,1-diphosphonic acids towards zinc(II), magnesium(II) and calcium(II) metal ions. Equilibrium s…
2017
Abstract Complex-formation abilities of a series of N-methyl alkylaminomethane-1,1-diphosphonic acids (1–7) with a common tertiary nitrogen atom (CH3−N−R) bearing linear or branched alkyl, cycloheptyl or phenylalkyl R substituents towards zinc(II), magnesium(II) and calcium(II) in aqueous solution have been studied by means of pH-potentiometry, ESI-MS spectrometry, 1H NMR and 31P NMR methods. The obtained results indicate that in the all presented systems mononuclear protonated equimolar and bis complexes are formed. In acidic and neutral solution, the formation of the protonated dinuclear species has been confirmed. The comparative analysis of the potentiometric and NMR data reveal that th…
Supercritical CO2 extraction of oil, fatty acids and flavonolignans from milk thistle seeds: Evaluation of their antioxidant and cytotoxic activities…
2015
International audience; The optimal conditions of supercritical carbon dioxide (SC-CO2) (160-220 bars, 40-80 degrees C) technology combined with co-solvent (ethanol), to recover oil, flavonolignans (silychristin, silydianin and silybinin) and fatty acids from milk thistle seeds, to be used as food additives and/or nutraceuticals, were studied. Moreover, the antioxidant and cytotoxic activities of the SC-CO2 oil seeds extracts were evaluated in Caco-2 carcinoma cells. Pressure and temperature had a significant effect on oil and flavonolignans recovery, although there was not observed a clear trend. SC-CO2 with co-solvent extraction at 220 bars, 40 degrees C was the optimum treatment to recov…
Velka on totaalinen sosiaalinen fakta
2015
Maailmantaloudessa kriisistä on tullut uusi normaalitila. 1990-luvun lopun Aasian ja Etelä-Amerikan taantumien logiikka toistuu 2000-luvulla Yhdysvalloissa ja vanhalla mantereella. Nämä kaikki kriisit ovat kehkeytyneet finanssitalouden keskeisimmän elementin, velan, logiikan mukaan. Velka ei ole kuitenkaan yksinomaan taloudellinen ilmiö. Pikemminkin se on valtasuhde, joka selittää esimerkiksi julkista keskustelua sosiaaliturvasta ja jäsentää ihmisten ajallisuutta. nonPeerReviewed
The carbon footprint of a knowledge organization and emission scenarios for a post-COVID-19 world
2021
Publisher Copyright: © 2021 The looming climate crisis requires an immediate response, in which organizations, as major contributors, should play a central role. However, these organizations need appropriate tools to measure and mitigate their climate impacts. One commonly applied method is carbon footprint analysis. Carbon footprint analyses have been conducted for various types of organizations, but knowledge organizations, such as universities and research institutes, have received far less attention, because their carbon footprint is often less visible and can be easily underestimated. This study is based on the carbon footprint analysis of one multinational knowledge organization. This…
SYNTHESIS AND ANTITUMOR ACTIVITY OF 2,5-BIS(3'-INDOLYL)-FURANS AND 3,5-BIS(3'-INDOLIY)-ISOXAZOLES, NORTOPSENTIN ANALOGUES
2010
Abstract A series of novel 2,5-bis(3′-indolyl)furans and 3,5-bis(3′-indolyl)isoxazoles were synthesized as antitumor agents. The antiproliferative activity was evaluated in vitro toward diverse human tumor cell lines. Initially 5 isoxazoles and 3 furan derivatives were tested against a panel of 10 human tumor cell lines and the most active derivatives 3c and 4a were selected to be evaluated in an extended panel of 29 cell lines. By exhibiting mean IC50 values of 17.4 μg/mL (3a) and 20.5 μg/mL (4c), in particular 4c showed a high level of tumor selectivity toward the 29 cell lines.
Pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine-4(3H)-ones, a new class of temozolomide heteroanalogues
2009
Twelve derivatives of new ring system pyrido[2’,3’:4,5]pyrrolo[2,1-d][1,2,3,5]tetrazine were prepared in good yields by reaction of 2-diazo-3-ethoxycarbonyl-pyrrolo[3,2-b]pyridine with alkyl- or aryl-isocyanates. Nine derivatives, screened by the National Cancer Institute (Bethesda, MD) for the in vitro one dose primary anticancer assay against a panel of about 60 human tumor cell lines, showed no significant activity.
Diastereoselective synthesis of 6-functionalized 4-aryl-1,3-oxazinan-2-ones and their application in the synthesis of 3-aryl-1,3-aminoalcohols and 6-…
2010
Abstract Halocyclocarbamation of benzyl N -(1-phenyl-3-butenyl)carbamates afforded 6-functionalized 4-aryl-1,3-oxazinan-2-ones with moderate to excellent diastereoselectivity depending on the N -substituent. Importantly, in contrast to reported cyclocarbamations of homoallylic carbamates, which are generally trans -diastereoselective, cyclization of N -unsubstituted Cbz-protected homoallylamines led to cis -1,3-oxazinan-2-ones, predominantly. The use of N -benzylated and in situ prepared N -silylated derivatives resulted however in trans -selectivity. Transition states are proposed to explain the stereochemical influence of the N -substituent on the cyclocarbamations. The functionalized 1,3…
Alkoholinkäytön aiheuttama liikennekuoleman riski Suomessa
2023
Tässä tutkimuksessa analysoidaan juopumuksen asteen vaikutusta kuolemaan johtavan liikenneonnettomuuden riskiin moderneilla tilastollisilla menetelmillä. Tutkimuksen pääaineistona ovat vuosina 2005–2014 Suomessa tapahtuneet kuolemaan johtaneet moottoriajoneuvo-onnettomuudet, joissa oli mukana henkilöauto aiheuttajana tai muuna osallisena. Pääaineistoa täydennetään ratsiatutkimuksista julkaistuilla tilastoilla. Keskeisiä käytettyjä mittareita ovat riskisuhde sekä vakioitu riskisuhde, josta on poistettu sekoittavien muuttujien vaikutusta. Tutkimuksen ensimmäisenä tavoitteena on selvittää, miten pieni veren alkoholipitoisuus alkaa lisätä liikenneonnettomuuden riskiä, ja toisena tavoitteena on …
Entre l’État et la chefferie simple : le complexe aristocratique de Vix/le mont Lassois
2021
International audience
Smiltsērkšķu marafivīrusa kodēto proteīnu klonēšana, ekspresija un raksturošana
2022
Smiltsērķšu marafivīruss (SBuMV) ir iepriekš neraksturots, smiltsērkšķus inficējošs vīruss. Tam ir divas atklātās translācijas fāzes (ORF), kur ORF1 kodē poliproteīnu, kas satur četrus proteīnu domēnus, bet ORF2 kodē apvalka proteīnu (CP). Šajā darbā tika izveidotas ekspresijas plazmīdas SBuMV kodētajiem proteīniem, taču E. coli sistēmā izdevās ekspresēt un attīrīt tikai abas CP formas un proteāzes (PRO) domēnu. Tika pārbaudīta PRO aktivitāte, PRO šķelšanas saits un verificēta PRO deubikvitināzes (DUB) aktivitāte. SBuMV mažorais CP E. coli spēj pašsavākties vīrusam līdzīgajās daļinās (VLP), bet minorais CP veido agregātus. Koekspresijas rezultātā, ja abas CP formas ekspresē no vienas plazmī…