Search results for "LLC"
showing 10 items of 21 documents
Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production of Interleukin-4
2007
A novel paradigm in tumor biology suggests that cancer growth is driven by stem-like cells within a tumor. Here, we describe the identification and characterization of such cells from colon carcinomas using the stem cell marker CD133 that accounts around 2% of the cells in human colon cancer. The CD133(+) cells grow in vitro as undifferentiated tumor spheroids, and they are both necessary and sufficient to initiate tumor growth in immunodeficient mice. Xenografts resemble the original human tumor maintaining the rare subpopulation of tumorigenic CD133(+) cells. Further analysis revealed that the CD133(+) cells produce and utilize IL-4 to protect themselves from apoptosis. Consistently, trea…
Telomere length and physical performance at older ages:an individual participant meta-analysis
2013
<p>Background: Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence for such an association is lacking. The purpose of this study was to examine whether change in telomere length is associated with physical performance.</p>\ud \ud <p>Methods: Using data from four UK adult cohorts (ages 53–80 years at baseline), we undertook cross-sectional and longitudinal analyses. We analysed each study separately and then used meta-analytic methods to pool the results. Physical performance was measured us…
Integrative genomic and proteomic analyses identify targets for Lkb1 deficient metastatic lung tumors
2010
SummaryIn mice, Lkb1 deletion and activation of KrasG12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and metastatic de novo lung cancers with integrated genomic and proteomic profiles, and have identified gene and phosphoprotein signatures associated with Lkb1 loss and progression to invasive and metastatic lung tumors. These studies revealed that SRC is activated in Lkb1-deficient primary and metastatic lung tumors, and that the combined inhibition of SRC, PI3K, and MEK1/2 resulted in synergistic tumor regression. These studies demonstrate that integrated genomic and proteomic analyses can be used to identify signaling pathw…
Energy Efficient Resource Allocation for Wireless Powered UAV Wireless Communication System with Short Packet
2023
The unmanned aerial vehicle (UAV), which is prominent in its flexibility and low cost, is considered to be fully utilized in the future wireless communication system to provide flexible services and improve connectivities. In this paper, we investigate the resource allocation problem in a wireless powered UAV communication system. In this considered system, The UAV acts as hybrid access point (HAP), which can first perform wireless power transfer in the downlink and charge the Internet of Thing (IoT) user devices (UDs). The UDs can use the harvested energy to deliver the data to the UAV. In the uplink, we explicitly consider short packet communication (SPC) as the transmission feature, whic…
Mismatch brain response to speech sound changes in rats
2011
Understanding speech is based on neural representations of individual speech sounds. In humans, such representations are capable of supporting an automatic and memory-based mechanism for auditory change detection, as reflected by the mismatch negativity of event-related potentials. There are also findings of neural representations of speech sounds in animals, but it is not known whether these representations can support the change detection mechanism analogous to that underlying the mismatch negativity in humans. To this end, we presented synthesized spoken syllables to urethane-anesthetized rats while local field potentials were epidurally recorded above their primary auditory cortex. In a…
Assessment of MOSFET switching losses in an LLC converter by a calorimetric method
2023
The present work aims to implement a calorimetric method to measure the power dissipated during MOSFET switching in a high efficiency LLC resonant converter. The power dissipated from switching can significantly impact the total power dissipated by the device and consequent efficiency, so correct quantification is fundamental for optimizing the devices and increasing the efficiency of the converters. In LLC converters, this type of dissipated power cannot be measured with standard methods such as measurement with oscilloscopes as some of the energy that is recovered and not dissipated. The calorimetric method requires reasonably accurate measurement of thermal resistance and the temperature…
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype
2006
In neuroblastoma specimens, HIF-2alpha but not HIF-1alpha is strongly expressed in well-vascularized areas. In vitro, HIF-2alpha protein was stabilized at 5% O2 (resembling end capillary oxygen conditions) and, in contrast to the low HIF-1alpha activity at this oxygen level, actively transcribed genes like VEGF. Under hypoxia (1% O2), HIF-1alpha was transiently stabilized and primarily mediated acute responses, whereas HIF-2alpha protein gradually accumulated and governed prolonged hypoxic gene activation. Knockdown of HIF-2alpha reduced growth of neuroblastoma tumors in athymic mice. Furthermore, high HIF-2alpha protein levels were correlated with advanced clinical stage and high VEGF expr…
SIA "BALTREISS" finanšu situācijas vērtējums un attīstības perspektīvas
2018
Diplomdarba darba mērķis ir, pamatojoties uz veikto SIA BALTREISS finansiālo analīzi, secināt, kādas ir uzņēmuma attīstības perspektīvas, un izstrādāt priekšlikumus SIA BALTREISS darbības pilnveidošanai. Diplomdarbs sastāv no četrām nodaļām - pirmajā nodaļā aplūkoti finanšu analīzes teorētiskie aspekti, otrajā nodaļā sniegts transporta nozares un SIA “BALTREISS” raksturojums. Trešajā nodaļā analizēti SIA “BALTREISS” finanšu rādītāji un finanšu analīzes koeficienti, savukārt ceturtajā nodaļā, iegūtie rezultāti salīdzināti ar transporta nozares un konkurenta SIA “SCHENKER” rādītājiem. Diplomdarba apjoms ir 66 lpp. un tas ietver 20 attēlus, 13 tabulas 35 izmantotās literatūras avotus un 7 piel…
Enseigner la phonologie en option LLCER anglais
2019
National audience
Somatosensory mismatch response in young and elderly adults
2014
Aging is associated with cognitive decline and alterations in early perceptual processes. Studies in the auditory and visual sensory modalities have shown that the mismatch negativity [or the mismatch response (MMR)], an event-related potential (ERP) elicited by a deviant stimulus in a background of homogenous events, diminishes with aging and cognitive decline. However, the effects of aging on the somatosensory MMR (sMMR) are not known. In the current study, we recorded ERPs to electrical pulses to different fingers of the left hand in a passive oddball experiment in young (22–36 years) and elderly (66– 95 years) adults engaged in a visual task. The MMR was found to deviants as compared to…