Search results for "LOAD"
showing 10 items of 1967 documents
Kondrat'eva ligation: Diels-Alder-based irreversible reaction for bioconjugation.
2014
International audience; Diversification of existing chemoselective ligations is required to efficiently access complex and well-defined biomolecular assemblies with unique and valuable properties. The development and bioconjugation applications of a novel Diels-Alder-based irreversible site-specific ligation are reported. The strategy is based on a Kondrat'eva cycloaddition between bioinert and readily functionalizable 5-alkoxyoxazoles and maleimides that readily react together under mild and easily tunable reaction conditions to afford a fully stable pyridine scaffold. The potential of this novel bioconjugation is demonstrated through the preparation of fluorescent conjugates of biomolecul…
Automatic Timeline Construction and Analysis For Computer Forensics Purposes
2014
International audience; To determine the circumstances of an incident, investigators need to reconstruct events that occurred in the past. The large amount of data spread across the crime scene makes this task very tedious and complex. In particular, the analysis of the reconstructed timeline, due to the huge quantity of events that occurred on a digital system, is almost impossible and leads to cognitive overload. Therefore, it becomes more and more necessary to develop automatic tools to help or even replace investigators in some parts of the investigation. This paper introduces a multi-layered architecture designed to assist the investigative team in the extraction of information left in…
X-ray irradiation influence on prototype Er3+-optical fibers: confocal luminescence study
2010
International audience; The integration of rare-earth doped optical fibers as part of fiber-based systems in space implies the development of waveguides tolerant to the radiation levels associated with the space missions. We report the spatial distribution, the photoluminescence (PL) properties of color centers and the related changes induced by X-rays radiation at different doses (50, 500 and 1000 krad) for two different prototypes of Er-doped optical fibers. Each sample (in the version pristine, X-irradiated and H2 loaded prior to radiation exposure) was characterized by confocal microscopy luminescence (CML) measurements in Visible range with Visible (488 nm) or UV (325 nm) laser light e…
Burden of HIV and hepatitis C co-infection: the changing epidemiology of hepatitis C in HIV-infected patients in France.
2015
Équipe UB/CHU (EA) Pôle MERS CT3 Hors Enjeu; International audience; Background & AimsTo better evaluate the HIV-HCV co-infection burden in the context of new effective HCV treatment. MethodsWe reviewed all the epidemiological data available on HCV-related disease in HIV-infected patients in France. Sources of data have been selected using the following criteria: (i) prospective cohorts or cross-sectional surveys; (ii) conducted at a national level; (iii) in the HIV-infected population; (iv) able to identify HCV co-infection and chronic active hepatitis C (HCV RNA positive); and (v) conducted during the period 2003-2012. ResultsThe overall prevalence of HIV-HCV co-infection has decreased fr…
Loss in microbial diversity affects nitrogen cycling in soil
2013
International audience; Microbial communities have a central role in ecosystem processes by driving the Earth's biogeochemical cycles. However, the importance of microbial diversity for ecosystem functioning is still debated. Here, we experimentally manipulated the soil microbial community using a dilution approach to analyze the functional consequences of diversity loss. A trait-centered approach was embraced using the denitrifiers as model guild due to their role in nitrogen cycling, a major ecosystem service. How various diversity metrics related to richness, eveness and phylogenetic diversity of the soil denitrifier community were affected by the removal experiment was assessed by 454 s…
Modular Assembly of Multimodal Imaging Agents through an Inverse Electron Demand Diels–Alder Reaction
2019
International audience; The combination of two imaging probes on a same biomolecule gives access to targeted bimodal imaging agents that can provide more accurate diagnosis, complementary information, or that may be used in different applications, such as PET imaging and fluorescence imagingassisted surgery. In this study, we demonstrate that dichlorotetrazine, a small, commercially available compound, can be used as a modular platform to easily assemble various imaging probes. Doubly-labeled tetrazines can then be conjugated to a protein through a biorthogonal IEDDA reaction. A series of difunctionalized tetrazine compounds containing various chelating agents and fluorescent dyes was synth…
Modeling and energy optimization of the operative parts of an air assisted drill
2016
In the context of sustainable farming, the optimization of the energy costs of agricultural operations allows shorter working times and high quality of the agricultural operations. This question relates particularly to the seeding. This operation one is decisive for the quality of the future harvest. The modern high capacity seed drills must be compatible with all the constraints. The main goal of this PhD thesis is thus to develop an innovative methodology, integrating the modeling tools, in order to reduce the energy consumption of the heavy seeding equipment. Thus, we explored four key aspects concerning air seed drill design: maneuverability of poly-articulated seed drills; establishmen…
MULTI AXIAL TESTING OF ADHESIVELY BONDEDJOINTS OF FIBER REINFORCED THERMOPLASTIC POLYMERS
2015
International audience; In order to predict the mechanical behaviorof adhesively bonded joints, it is necessary to develop robust numerical models.This robustness is only reached if an extensive experimental database with tensile, shear and complex combined peel and shear loads can beestablished. The purpose of this study is to present a multi axialdevice for testing adhesively bonded joints, using KS2-type specimens traditionally utilized for spot-weld characterization. The tests were conducted on a glass fiber reinforced thermoplastic polymer(PA6-6) composite adhesively bonded with a flexible polyurethane adhesive. This adhesive/substrate combination allowsshort process times and good per…
On the Impact of Heat Pumps Electric Load on the Power Consumption of Lampedusa
2020
The present paper reports the results of a simulation study regarding the impact of the adoption of heat pumps for domestic hot water production in the island of Lampedusa (Italy). In the study, it has been assumed to replace electric storage water heaters with heat pumps at every dwelling of the about four thousand domestic end-users of the island and, in addition, to control the heat pump operation in order to enhance some parameters that characterize the quality of the generation and distribution system of the island (power peak, energy losses and voltage drop). According to the results of the simulations, while the replacement of electric storage water heaters with heat pumps is able to…
Browsing the information highway while driving: three in-vehicle touch screen scrolling methods and driver distraction
2012
Distraction effects of three alternative touch screen scrolling methods for searching music tracks on a mobile device were studied in a driving simulation experiment with 24 participants. Page-bypage scrolling methods with Buttons or Swipe that better facilitate resumption of visual search following interruptions were expected to lead to more consistent in-vehicle glance durations and thus, on less severe distraction effects than Kinetic scrolling. As predicted, Kinetic scrolling induced decreased visual sampling efficiency and increased visual load compared to Swipe, increased experienced workload compared to both Buttons and Swipe, as well as decreased lane keeping accuracy compared to ba…