Search results for "LOAD"
showing 10 items of 1967 documents
MRI-Visible Poly(ε-caprolactone) with Controlled Contrast Agent Ratios for Enhanced Visualization in Temporary Imaging Applications
2013
International audience; Hydrophobic macromolecular contrast agents (MMCAs) are highly desirable to provide safe and efficient magnetic resonance (MR) visibility to implantable medical devices. In this study, we report on the synthesis and evaluation of novel biodegradable poly(ε-caprolactone)-based MMCAs. Poly(α-propargyl-ε-caprolactone-co-ε-caprolactone)s containing 2, 5, and 10 mol % of propargyl groups have been prepared by ring-opening copolymerization of ε-caprolactone and the corresponding propargylated lactone. In parallel, a diazido derivative of the clinically used diethylenetriaminepentaacetic acid (DTPA)/Gd3+ complex has been synthesized. Finally, MRI-visible poly(ε-caprolactone)…
Kinetics of cytomegalovirus (CMV) pp65 and IE-1-specific IFNgamma CD8+ and CD4+ T cells during episodes of viral DNAemia in allogeneic stem cell tran…
2010
The dynamics of CMV pp65 and IE-1-specific IFNgamma-producing CD8(+) (IFNgamma CD8(+)) and CD4(+) (IFNgamma CD4(+)) T cells and CMV DNAemia were assessed in 19 pre-emptively treated episodes of active CMV infection. Peripheral counts of IFNgamma CD8(+) and IFNgamma CD4(+) T cells inversely correlated with CMV DNAemia levels (P = <0.001 and P = 0.003, respectively). A threshold value of 1.3 cells/microl predicting CMV DNAemia clearance was established for IFNgamma CD8(+) T cells (PPV, 100%; NPV, 93%) and for IFNgamma CD4(+) T cells (PPV, 100%; NPV, 75%). Undetectable T-cell responses were usually observed at the time of initiation of pre-emptive therapy. Either a rapid (within 7 days) or a d…
DI-032 Study of effectiveness and safety of foscarnet in cytomegalovirus treatment in haematopoietic stem cell transplantation recipients
2016
Background Cytomegalovirus disease is an important cause of morbidity and mortality in haematopoietic stem cell transplantation (HSCT) recipients. Foscarnet, an intravenous drug active against cytomegalovirus, represents an increasingly widespread alternative when there is resistance or intolerance to conventional treatments (ganciclovir/valganciclovir, acyclovir). More data about its use, effectiveness and safety in the clinical practice are necessary. Purpose To analyse the effectiveness and safety of the use of foscarnet against cytomegalovirus in HSCT recipients, and its adaptation to clinical practice guidelines and expert recommendations in order to optimise future treatment strategie…
Immunological insights into the pathogenesis of active CMV infection in non-immunosuppressed critically ill patients.
2011
Dissociation of cytomegalovirus (CMV) DNA loads between the lower respiratory tract and blood, with high levels in the former compartment and low or undetectable levels in the latter, commonly occurs during active CMV infection in critically ill patients despite the presence of high frequencies of CMV-specific IFN-γ-producing CD8+ and CD4+ T cells in blood. Data presented in this case report suggest that inter-compartmental differences in interleukin-10 (IL-10) levels may, in part, explain the pathobiology of this phenomenon. In the absence of ganciclovir treatment, a significant correlation was observed between IL-10 levels and CMV DNA loads in lower respiratory tract specimens (P = 0.016)…
Unifying prospective and retrospective interval-time estimation: A fading-Gaussian activation-based model of interval-timing
2014
International audience; Hass and Hermann (2012) have shown that only variance-based processes will lead to the scalar growth of error that is characteristic of human time judgments. Secondly, a major meta-review of over one hundred studies (Block et al., 2010) reveals a striking interaction between the way in which temporal judgments are queried and cognitive load on participants’ judgments of interval duration. For retrospective time judgments, estimates under high cognitive load are longer than under low cognitive load. For prospective judgments, the reverse pattern holds, with increased cognitive load leading to shorter estimates. We describe GAMIT, a Gaussian spreading-activation model,…
Human Heart-Related Indexes Behavior Study for Aircraft Pilots Allowable Workload Level Assessment
2022
This study aimed to evaluate workload by detecting Heart Rate Variability (HRV) indexes in a sample of 34 pilots (with a mean age of 33 years) while performing simulated flight exercises. A one-way ANOVA with repeated measures was performed to assess the changes of the physiological measures in five standard maneuvers associated with different workload levels. The results show that all the indexes, but the Low Frequency to High Frequency ratio index (LF/HF), have a well-defined trend between the baseline and the en-route phase and with the three phases takeoff, steady turn, and landing. This study, as main findings, provides evidence of a differentiation among low, medium, and high workload…
Energy Efficient Scheduling in Content Distribution Collaborative Mobile Clusters
2020
Most of the existing literatures on green communications aimed to improve the energy efficiency at the base station or data server. However, in order to fully experience high rate broadband multimedia services, prolonging the battery life of user equipment is also critical for the mobile terminals, especially for the smartphone users. In this work, we investigate the problem of designing a content distribution mobile platform named collaborative mobile clusters (CMC) via user cooperation to reduce the energy consumption at the terminal side. Specifically, given numbers of users interested in downloading a common content from the operator, both centralized and distributed user grouping and s…
Unveiling the Chemistry of Higher-Order Cycloaddition Reactions within the Molecular Electron Density Theory
2022
The higher-order cycloaddition (HOCA) reaction of tropone with cyclopentadiene (Cp) has been studied within the Molecular Electron Density Theory. The Electron Localization Function (ELF) analysis of the electronic structure of tropone and Cp characterizes the structural behaviors of the two conjugated unsaturated systems, while the conceptual DFT reactivity indices classify tropone as a strong electrophile and Cp as a strong nucleophile participating in polar cycloaddition reactions of reverse electron density flux. Eight competitive reaction paths have been characterized for this cycloaddition reaction. The most favorable one allowing the formation of the formal out [6 + 4] cycloadduct ha…
Inventory record inaccuracy in supply chains: the role of workers' behavior
2014
Purpose – The purpose of this paper is to explore the effect of inventory record inaccuracy due to behavioral aspects of workers on the order and inventory variance amplification. Design/methodology/approach – The authors adopt a continuous-time analytical approach to describe the effect of inbound throughput on the inventory and order variance amplification due to the workload pressure and arousal of workers. The model is numerically solved through simulation and results are analyzed with statistical general linear model. Findings – Inventory management policies that usually dampen variance amplification are not effective when inaccuracy is generated due to workers’ behavioral aspects. Sp…
On the moving multi-loads problem in discontinuous beam structures with interlayer slip
2017
Abstract This contribution proposes an efficient approach to the moving multi-loads problem on two-layer beams with interlayer slip and elastic translational supports. The Euler-Bernoulli hypothesis is assumed to hold for each layer separately, and a linear constitutive relation between the horizontal slip and the interlaminar shear force is considered. It is shown that, using the theory of generalized functions to treat the discontinuous response variables, exact eigenfunctions can be derived from a characteristic equation built as determinant of a 6 x 6 matrix. Building pertinent orthogonality conditions for the deflection eigenfunctions, a closed-form analytical response is established i…