Search results for "LOCI"

Analyzing the electrophysiological effects of local epicardial temperature in experimental studies with isolated hearts

2008

As a result of their modulating effects upon myocardial electrophysiology, both hypo- and hyperthermia can be used to study the mechanisms that generate or sustain cardiac arrhythmias. The present study describes an original electrode developed with thick-film technology and capable of controlling regional temperature variations in the epicardium while simultaneously registering its electrical activity. In this way, it is possible to measure electrophysiological parameters of the heart at different temperatures. The results obtained with this device in a study with isolated and perfused rabbit hearts are reported. An exploration has been made of the effects of local temperature changes upon…

Association Between Previously Identified Disease Loci At Chr12q15 and Chr1p36 and UC in Italian Population

2009

Probing the low-temperature chemistry of ethanol via the addition of dimethyl ether

2018

Considering the importance of ethanol (EtOH) as an engine fuel and a key component of surrogate fuels, the further understanding of its auto-ignition and oxidation characteristics at engine-relevant conditions (high pressures and low temperatures) is still necessary. However, it remains difficult to measure ignition delay times for ethanol at temperatures below 850 K with currently available facilities including shock tube and rapid compression machine due to its low reactivity. Considering the success of our recent study of toluene oxidation under similar conditions [38], dimethyl ether (DME) has been selected as a radical initiator to explore the low-temperature reactivity of ethanol. In …

An Analysis of the Time-Varying Behavior of the Equilibrium Velocity of Money in the Euro Area

2020

Recent developments in inflation and M3 velocity in the euro area have raised serious doubts about the reliability of M3 growth as a pillar of the ECB’s monetary policy strategy. We develop a very flexible and comprehensive state-space framework for modeling the velocity of circulation. Our specification allows for the estimation of different autoregressive alternatives and includes control instruments, whose coefficients can be set up either common or idiosyncratic. This is particularly useful to detect asymmetries in the reaction among countries to common shocks. Our findings first suggest that the downward trend of M3 velocity is mainly explained by the evolution of permanent income, pro…

L’infrastruttura scomparsa. Il nuovo suolo della stazione Alta Velocità La Sagrera a Barcellona

2017

L’enorme progetto appena completato a Barcellona per il nuovo polo ferroviario della stazione Sagrera si caratterizza soprattutto per il legame fra la nuova stazione dell’Alta Velocità (AVE) e il vasto parco lineare, progetto opera di West 8, che copre la lunga trincea un tempo determinata nel tessuto urbano dai binari preesistenti. Ricostruendo il quadro di uno dei più grandi e ambiziosi progetti di rigenerazione urbana legati all’infrastruttura ferroviaria oggi in Europa, questo articolo si concentra sulla subordinazione della stazione al parco. Non si tratta di una semplice condizione di posizione (la stazione è letteralmente sotto il parco), ma di una nuova e sempre più diffusa condizio…

Infrastructure as interface. Thinking the urban and the high -speed station: italian case-studies.

2011

This presentation will document some results of an ongoing research focusing on the role of infrastructure in contemporary design practice. The methodology is based on critical design theory and combines theoretical aspects with a case-study approach, at the junction of infrastructure, urban design and architecture. It is already well documented that 19th and 20th century infrastructure have deeply affected their programs in order to face new challenges over the last 30 decades. Railway stations are leading examples in this fields: they have gradually implemented their design, that already integrated commercial spaces and facilities, until involving in public space transformation. Instead, …

Détour topologique Les opérations TAV italiennes et la redéfinition architecturale des gares

2010

Aujourd’hui convoquées en Europe comme catalyseurs de transformations urbaines, les gares se posent comme condition pour fabriquer la ville dans des opérations reliant la modernisation du réseau ferré et l’introduction des la Grande Vitesse à d’importantes opérations de réaménagement de leurs contextes. La mise en perspective des scénarios liés aux projets des gares TAV italiennes lancés en 2001révèle que le bâtiment devient enjeu pour concevoir la ville grâce à une profonde redéfinition de ses caractères principaux, soutenue par l’émergence de la dimension topologique au détriment de celle typologique, essentielle pour les gares du siècle dernier. La conception de l’édifice rejette toute f…

The Gaia-ESO Survey: membership and initial mass function of the. Velorum cluster

2016

Understanding the properties of young open clusters, such as the Initial Mass Function (IMF), star formation history and dynamic evolution, is crucial to obtain reliable theoretical predictions of the mechanisms involved in the star formation process. We want to obtain a list, as complete as possible, of confirmed members of the young open cluster Gamma Velorum, with the aim of deriving general cluster properties such as the IMF. We used all available spectroscopic membership indicators within the Gaia-ESO public archive together with literature photometry and X-ray data and, for each method, we derived the most complete list of candidate cluster members. Then, we considered photometry, gra…

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

2010

Combined analyses of gene networks and DNA sequence variation can provide new insights into the aetiology of common diseases that may not be apparent from genome-wide association studies alone. Recent advances in rat genomics are facilitating systems-genetics approaches. Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF7)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epst…

Physiological responses of running intermittent exercises

2012

The aims of the present work were to analyze the physiological responses during intermittent exercise and to determine; i) an field test to assess the maximal aerobic velocity (MAV) for intermittent exercise; ii) the type of intermittent exercise could elicit maximal oxygen uptake (VO2max); iii) the physiological and neuromuscular factors that could limit intermittent exercise duration.The first study demonstrated that the MAV (MAV45-15) reached at the end of an incremental intermittent (45s run/ 15s rest) field test (45-15FIT) was relevant to elicit a high percentage of VO2max during a 30s-30s intermittent training session. The second and third studies demonstrated that intermittent exerci…