Search results for "LOCUS"
showing 10 items of 632 documents
Pest Plant Score of Alien Robinia Pseudoacacia in Rīga (Latvia) and Kaunas (Lithuania) / Svešzemju Sugas Robinia Pseudoacacia Invazitātes Novērtējums…
2015
Abstract Robinia pseudoacacia is an alien tree species that has wide distribution in green areas of Rīga and Kaunas. In recent years, the spread and invasion of this species was observed. The aim of this study was to determine the relative importance of invasiveness of R. pseudoacacia in Rīga and Kaunas. The degree of species invasion was estimated by applying the Pest Plant Prioritization Process, which is based on the Analytic Hierarchy Process method. The results showed that the invasive degree of R. pseudoacacia was near medium (0.4); the present compared to potential distribution rating was medium (0.57) and the social, environmental and economic impact score was very low (0.17). The F…
IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci
2010
A recent meta-analysis identified seven single-nucleotide polymorphisms (SNPs) with suggestive evidence of association with multiple sclerosis (MS). We report an analysis of these polymorphisms in a replication study that includes 8,085 cases and 7,777 controls. A meta-analysis across the replication collections and a joint analysis with the discovery data set were performed. The possible functional consequences of the validated susceptibility loci were explored using RNA expression data. For all of the tested SNPs, the effect observed in the replication phase involved the same allele and the same direction of effect observed in the discovery phase. Three loci exceeded genome-wide significa…
Environmental Public Law: NGOs’ locus standi in Italian Case Law
2021
The paper focuses on NGOs’ locus standi in Italian Case Law
Adolescenti affetti da insufficienza renale cronica: impatto dei fattori psicologici e relazionali intervenienti sulla gestione delle cure e sulla qa…
2008
L'insufficienza renale (I.R.C.) è la perdita permanente della funzione renale, causata dalla progressione di una nefropatia ad andamento cronico, o da un danno irreversibile. Questa ricerca intende valutare il ruolo di alcuni elementi centrali nella gestione della patologia, quali: precezione del supporto socio-familiare, locus of control interno/esterno, compliance. metodologia edi ricerca di tipo cross-sectional correlazionale. I risultati evidenziano (tramite R di Pearson) correlazione positiva tra la scala "medici£ del test sul locus of control e la compliance al trattamento. Dallo studio emerge il forte valore dato dai soggetti alle indicazioni dei medici, al supporto dei familiari,ris…
Neuronal Nicotinic Receptors in the Locust Locusta migratoria
1998
We have identified five cDNA clones that encode nicotinic acetylcholine receptor (nAChR) subunits expressed in the nervous system of the locust Locusta migratoria. Four of the subunits are ligand-binding α subunits, and the other is a structural β subunit. The existence of at least one more nAChR gene, probably encoding a β subunit, is indicated. Based on Northern analysis and in situ hybridization, the five subunit genes are expressed. locα1, locα3, andlocβ1 are the most abundant subunits and are expressed in similar areas of the head ganglia and retina of the adult locust. Because Locα3 binds α-bungarotoxin with high affinity, it may form a homomeric nAChR subtype such as the mammalian α7…
A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol
2011
Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene–environment interactions for circulating lipids has been reported. We screened for variants that modify the relationship between known epidemiological risk factors and circulating lipid levels in a meta-analysis of genome-wide association (GWA) data from 18 population-based cohorts with European ancestry (maximum N = 32,225). We collected 8 further cohorts (N = 17,102) for replication, and rs6448771 on 4p15 demonstrated genome-wide significant interaction with waist-to-hip-ratio (WHR) on …
Genetic architecture of circulating lipid levels
2011
Serum concentrations of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and total cholesterol (TC) are important heritable risk factors for cardiovascular disease. Although genome-wide association studies (GWASs) of circulating lipid levels have identified numerous loci, a substantial portion of the heritability of these traits remains unexplained. Evidence of unexplained genetic variance can be detected by combining multiple independent markers into additive genetic risk scores. Such polygenic scores, constructed using results from the ENGAGE Consortium GWAS on serum lipids, were applied to predict lipid levels in an independen…
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumpti…
2011
Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in autism susceptibility candidate 2 gene ( AUTS2 ) was associated with alcohol consumption at genome-wide significance ( P = 4 × 10 −8 to P = 4 × 10 −9 ). We found a genotype-specific expression of AUTS2 in 9…
Localization of the giant axonal neuropathy gene to chromosome 16q24
1998
Giant axonal neuropathy (GAN) is a degenerative disorder of the peripheral nerves that is inherited as an autosomal recessive trait, presenting in early childhood and progressing to death, usually by late adolescence. Diagnosis is made by peripheral nerve biopsy, in which a striking pathological finding is seen--fibers distorted by giant axonal swellings filled with densely packed bundles of neurofilaments (the primary intermediate filament in neurons), with segregation of other axoplasmic organelles. In addition to disorganized neurofilaments in nerve, disorganization of other members of the intermediate filament family of proteins is seen in other tissues; this implies that the underlying…
Neuronal populations mediating the effects of endocannabinoids on stress and emotionality
2011
An adequate emotional response to stress is essential for survival and requires the fine-tuned regulation of several distinct neuronal circuits. Therefore, a precise control of these circuits is necessary to prevent behavioral imbalances. During the last decade, numerous investigations have evidenced that the endocannabinoid (eCB) system is able to crucially control stress coping. Its central component, the cannabinoid type 1 receptor (CB1 receptor), is located at the presynapse, where it is able to attenuate neurotransmitter release after its activation by postsynaptically produced and released eCBs. To date, the eCB system has been found to control the neurotransmitter release from severa…