Search results for "LONG"
showing 10 items of 3969 documents
Bed-side inferior vena cava diameter and mean arterial pressure predict long-term mortality in hospitalized patients with heart failure: 36 months of…
2015
In discharged patients with heart failure (HF), diverse conditions can intervene to worsen outcome. We would investigate whether such factors present on hospital admission can affect long-term mortality in subjects hospitalized for acute HF.One hundred twenty-three consecutive patients hospitalized for acute HF (mean age 74.8 years; 57% female) were recruited and followed for 36 months after hospitalization.At multivariate Cox model, only inferior vena cava (IVC) diameter and mean arterial pressure (MAP) registered bed-side on admission, resulted, after correction for all confounders factors, the sole factors significantly associated with a higher risk of all-cause mortality in long-term (H…
Obesity and reduction of the response rate to anti-tumor necrosis factor α in rheumatoid arthritis: an approach to a personalized medicine.
2013
Objective Obesity is a mild, long-lasting inflammatory disease and, as such, could increase the inflammatory burden of rheumatoid arthritis (RA). The study aim was to determine whether obesity represents a risk factor for a poor remission rate in RA patients requiring anti–tumor necrosis factor α (anti-TNFα) therapy for progressive and active disease despite treatment with methotrexate or other disease-modifying antirheumatic drugs. Methods Patients were identified from 15 outpatient clinics of university hospitals and hospitals in Italy taking part in the Gruppo Italiano di Studio sulle Early Arthritis network. Disease Activity Score in 28 joints (DAS28), body mass index (BMI; categorized …
A comparison of efficacy and safety of an ezetimibe/simvastatin combination compared with other intensified lipid-lowering treatment strategies in di…
2013
The low-density lipoprotein cholesterol (LDL-C) lowering efficacy of switching to ezetimibe/simvastatin (EZ/S) 10/20 mg versus doubling the run-in statin dose (to simvastatin 40 mg or atorvastatin 20 mg) or switching to rosuvastatin 10 mg in subjects with cardiovascular disease (CVD) and diabetes was assessed. Endpoints included percentage change in LDL-C and percentage of patients achieving LDL-C <70 mg/dL. Significantly greater reductions in LDL-C occurred when switching to EZ/S versus statin doubling in the overall population and in subjects treated with simvastatin 20 mg or atorvastatin 10 mg (all p < 0.001). The LDL-C reduction was numerically greater when switching to EZ/S vers…
La gestión de casos como metodología para la conexión de los sistemas sanitario y social en España
2015
ResumenObjetivoEl objetivo de este artículo es presentar la evaluación de un proyecto de gestión de casos con pacientes crónicos en Valencia para la integración de la atención social y sanitaria. Este proyecto está vinculado con el «Modelo sociosanitario sostenible».EmplazamientoDepartamento de Salud 6, Comunidad Valenciana.ParticipantesPacientes con patologías crónicas de 65 o más años.IntervencionesEstudio comparativo con un grupo control y otro de intervención, no aleatorizado ni ciego. La intervención consistió en la creación de un equipo interdisciplinar de gestión de casos, el uso de una cartera común de recursos y su aplicación a una muestra piloto. Duración de la intervención: 6-9 m…
Linguistic and spatial skills predict early arithmetic development via counting sequence knowledge
2013
Utilizing a longitudinal sample of Finnish children (ages 6-10), two studies examined how early linguistic (spoken vs. written) and spatial skills predict later development of arithmetic, and whether counting sequence knowledge mediates these associations. In Study 1 (N = 1,880), letter knowledge and spatial visualization, measured in kindergarten, predicted the level of arithmetic in first grade, and later growth through third grade. Study 2 (n = 378) further showed that these associations were mediated by counting sequence knowledge measured in first grade. These studies add to the literature by demonstrating the importance of written language for arithmetic development. The findings are …
Validating rationale of group-level component analysis based on estimating number of sources in EEG through model order selection
2012
This study addresses how to validate the rationale of group component analysis (CA) for blind source separation through estimating the number of sources in each individual EEG dataset via model order selection. Control children, typically reading children with risk for reading disability (RD), and children with RD participated in the experiment. Passive oddball paradigm was used for eliciting mismatch negativity during EEG data collection. Data were cleaned by two digital filters with pass bands of 1-30 Hz and 1-15 Hz and a wavelet filter with the pass band narrower than 1-12 Hz. Three model order selection methods were used to estimate the number of sources in each filtered EEG dataset. Un…
Effects of different unstable supports on EMG activity and balance
2013
This study analysed the equilibrium strategies and EMG activity during postural equilibrium in four different unstable surfaces. Thirteen team sport males were tested on a FLAT surface and on three different wobble boards (JAKOBS(®) with easy multidirectional displacements, FREEMAN with strong multidirectional displacements and LATERAL with unidirectional lateral displacements). They had to maintain single-limb stance during 5s for each condition. The right foot centre of pressure (COP) position and its variability with concomitant EMG activity of soleus (SOL), tibialis anterior (TA), peroneus longus (PL) and extensor digitorum longus (EXD) muscles were recorded. Subjects maintained balance…
The antidepressant-like effect of tDCS in mice: A behavioral and neurobiological characterization
2017
Abtract Background Transcranial direct current stimulation (tDCS) is a non-invasive method increasingly popular for the treatment of several brain disorders, such as major depression. Despite great enthusiasm and promising results, some studies report discrepant findings and no consensus exists for the clinical use of tDCS. Objective The present study aims to (i) determine the most effective stimulation parameters to optimize antidepressant-like effect of tDCS in the forced-swim test in mice and (ii) identify brain regions recruited by tDCS and possibly involved in its behavioral effect using Fos immunohistochemistry. Results We reported that tDCS induced long-lasting antidepressant-like ef…
Temporal Trends in the Incidence of Ischemic Stroke in Young Adults: Dijon Stroke Registry
2021
<b><i>Introduction:</i></b> Stroke is associated with major consequences in terms of socioeconomic impact and lost disability-adjusted life in young victims, thus justifying a careful surveillance of epidemiological trends. This study aimed to assess changes in the incidence of ischemic stroke in young adults over a long period. <b><i>Methods:</i></b> All cases of first-ever ischemic stroke that occurred among adults aged 18–55 years were prospectively recorded using the population-based Dijon Stroke Registry, from 1985 to 2017. Sex-specific annual incidence rates were calculated and were presented according to 6 time periods. Incidence rate r…
The development and predictive relations of play and language across the second year
1999
The play and language development of 171 toddlers was examined at 14 and 18 months by observing their activities on the Symbolic Play Test and by assessing their language skills using the MacArthur Communicative Development Inventories (MCDI) and the Reynell Developmental Language Scales. Additionally, data from the Bayley Scales of Infant Development and the MCDI were obtained at 24 months, in order to investigate how play and language measures taken at 14 and 18 months predict children's development at the age of 2 years. The results showed that the vocabulary production and symbolic play of the 14-month-old toddlers made a unique contribution to their language and cognitive skills at the…