Search results for "LONG"
showing 10 items of 3969 documents
Could the recent zika epidemic have been predicted?
2017
AbstractGiven knowledge at the time, the recent 2015-2016 zika virus (ZIKV) epidemic probably could not have been predicted. Without the prior knowledge of ZIKV being already present in South America, and given the lack of understanding of key epidemiologic processes and long-term records of ZIKV cases in the continent, the best related prediction was for potential risk of an Aedes-borne disease epidemic. Here we use a recently published two-vector capacity model to assess the predictability of the conditions conducive to epidemics of diseases like zika, chikungunya or dengue, transmitted by the independent or concurrent presence of Aedes aegypti and Aedes albopictus. We compare the potenti…
Selective growth-inhibitory effect of 8-hydroxyquinoline towards Clostridium difficile and Bifidobacterium longum subsp. longum in co-culture analyse…
2014
The major risk factor for Clostridium difficile infection (CDI) is the use of antibiotics owing to the disruption of the equilibrium of the host gut microbiota. To preserve the beneficial resident probiotic bacteria during infection treatment, the use of molecules with selective antibacterial activity enhances the efficacy by selectively removing C. difficile. One of them is the plant alkaloid 8-hydroxyquinoline (8HQ), which has been shown to selectively inhibit clostridia without repressing bifidobacteria. Selective antimicrobial activity is generally tested by culture techniques of individual bacterial strains. However, the main limitation of these techniques is the inability to describe …
Occurrence of CTX-M Producing Escherichia coli in Soils, Cattle, and Farm Environment in France (Burgundy Region).
2012
Article en open access; International audience; CTX-M [a major type of extended-spectrum beta-lactamase (ESBU] producing Escherichia coli are increasingly involved in human infections worldwide. The aim of this study was to investigate potential reservoirs for such strains: soils, cattle, and farm environment. The prevalence of bla(CTX-M) genes was determined directly from soil DNA extracts obtained from 120 sites in Burgundy (France) using real-time PCR. bla(CTX-M) targets were found in 20% of the DNA extracts tested. Samples of cattle feces (n = 271) were collected from 182 farms in Burgundy. Thirteen ESBL-producing isolates were obtained from 12 farms and further characterized for the pr…
Landmarks for vertebral artery repositioning in bulbar compression syndrome: anatomic and microsurgical nuances
2004
Abstract OBJECTIVE: The purpose of this study was to better elucidate the anatomic relationship between the vertebral artery (VA) along with its perforating vessels and the brainstem to develop anatomic guidelines that would be helpful when decompressing medulla oblongata compressed by the VA. METHODS: Microanatomy dissection was performed in six formalin-fixed cadaveric heads. The VA, posteroinferior cerebellar artery (PICA), anteroinferior cerebellar artery (AICA), and lower brainstem perforators were examined under magnification using a surgical microscope. The outer diameters of the VA, PICA, and AICA were measured. The distance between the VA, lying within the lateral cerebellomedullar…
Sense of belonging to Latvia in Latvian- and Russian-speaking residents of Latvia
2019
This study examined the sense of belonging to Latvia in Latvian-speaking and Russianspeaking residents of Latvia. The structural model involved opportunities for the fulfillment of personal goals and views of the situation in Latvia and the community as predictors of the sense of belonging at both levels of ecological systems. The Russianspeaking subsample consisted of 202 students ranging in age from 18 to 36 (65% females). The Latvian-speaking subsample involved 438 students ranging in age from 18 to 37 (67% females). The Sense of Belonging in Social Context Questionnaire and the Future of Country Questionnaire were applied. Belonging to community predicted belonging to Latvia in both gro…
Genes, Ageing and Longevity in Humans: Problems, Advantages and Perspectives.
2006
Many epidemiological data indicate the presence of a strong familial component of longevity that is largely determined by genetics, and a number of possible associations between longevity and allelic variants of genes have been described. A breakthrough strategy to get insight into the genetics of longevity is the study of centenarians, the best example of successful ageing. We review the main results regarding nuclear genes as well as the mitochondrial genome, focusing on the investigations performed on Italian centenarians, compared to those from other countries. These studies produced interesting results on many putative "longevity genes". Nevertheless, many discrepancies are reported, l…
Fitness and life-history traits of the two major mitochondrial DNA haplotypes of Drosophila subobscura
2004
Mitochondrial DNA restriction site analyses on natural populations of Drosophila subobscura have proved the existence of two common, coexisting haplotypes (I and II), as well as a set of less frequent ones derived from them. To explain this distribution, experiments to date point practically to all possible genetic mechanisms being involved in the changes of gene frequencies (cytonuclear coadaptation, direct natural selection on mtDNA and genetic drift). In an attempt to find differences that help to understand the dynamics of these haplotypes and to detect the effect of selection, we measured certain fitness components and life-history traits (egg-larva and larva-adult viabilities and deve…
Mobilités et changements de catégories : portée et limites des données longitudinales : XIXes journées d'étude sur les données longitudinales dans l'…
2012
De nombreuses recherches ont déjà démontré l'apport des données longitudinales pour déchiffrer le passage d'un état à un autre, et signaler des états transitoires, précaires ou durables, plus ou moins réversibles, plus ou moins ajustés aux attentes et aux dispositifs, en particulier entre formation et emploi. Des catégories ont été construites à l'appui de réflexions interdisciplinaires, telles que celles de transition, de cheminement long, de parcours, de carrières et bien d'autres. Dans un contexte sociétal où tout semble changer en même temps et où il est difficile de démêler les effets structurels et conjoncturels, ces avancées incitent aujourd'hui à attaquer de front la question comple…
Les transitions professionnelles tout au long de la vie. Nouveaux regards, nouveaux sens, nouvelles temporalités ?
2016
Les XXIIIèmes journées du longitudinal (JDL) proposent cette année de porter un nouveau regard sur les transitions professionnelles. Il ne s'agit plus seulement d'une menace qu'il faut craindre mais également, sous certaines conditions, d'opportunités dans le parcours des individus, susceptibles d'ouvrir à une réorientation professionnelle ou à de nouvelles perspectives de mobilités. La problématique des transitions professionnelles tout au long de la vie se propose donc d'englober, d'une part les dynamiques à l'oeuvre dans les parcours biographiques et professionnels au-delà des seules périodes d'entrée dans la vie active et, d'autre part, les conséquences des changements structurels et in…
HEXIM1 Diffusion in the Nucleus Is Regulated by Its Interactions with Both 7SK and P-TEFb
2019
International audience; How nuclear proteins diffuse and find their targets remains a key question in the transcription field. Dynamic proteins in the nucleus are classically subdiffusive and undergo anomalous diffusion, yet the underlying physical mechanisms are still debated. In this study, we explore the contribution of interactions to the generation of anomalous diffusion by the means of fluorescence spectroscopy and simulation. Using interaction-deficient mutants, our study indicates that HEXIM1 interactions with both 7SK RNA and positive transcription elongation factor b are critical for HEXIM1 subdiffusion and thus provides evidence of the effects of protein-RNA interaction on molecu…