Search results for "LONG"
showing 10 items of 3969 documents
Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excit…
2008
Abstract Corticotropin releasing hormone (CRH) is the central modulator of the mammalian hypothalamic–pituitary–adrenal (HPA) axis. In addition, CRH affects other processes in the brain including learning, memory, and synaptic plasticity. Moreover, CRH has been shown to play a role in nerve cell survival under apoptotic conditions and to serve as an endogenous neuroprotectant in vitro . Employing mice overexpressing murine CRH in the CNS, we observed a differential response of CRH-overexpressing mice (CRH-COE hom -Nes) to acute excitotoxic stress induced by kainate compared with controls (CRH-COE con -Nes). Interestingly, CRH-overexpression reduced the duration of epileptic seizures and pre…
The non-aromatizable androgen dihydrotestosterone (DHT) facilitates sexual behavior in ovariectomized female rats primed with estradiol
2020
Abstract It is still unclear whether Testosterone (T) increases sexual desire through a stimulation of the androgen receptor in relevant brain regions or through its conversion to estrogens. The aim of this study was to clarify the mechanisms of T facilitation of female sexual desire by assessing the effect of a non-aromatizable androgen (Dihydrotestosterone, DHT) in a validated animal model. Ovariectomized (OVX) Long-Evans rats were treated with oil (O) + O, 10 mcg Estradiol Benzoate (EB) + O, 10 mcg EB + 500 mcg Progesterone (P), O + 500 mcg DHT or 10 mcg EB + 500 mcg DHT (n = 12 per group). EB was administered 48 h, while P and DHT 4 h, prior to 4 sexual behavioral testing sessions in bi…
Sperm quality, secondary sexual characters and parasitism in roach (Rutilus rutilus L.)
2004
According to sperm competition models, a male spawning in a disfavoured role should have spermatozoa with higher velocity but shorter longevity compared with a male spawning in a favoured role. Moreover, immunosuppressive androgens are needed to produce both secondary sexual characters and sperm cells. The ‘sperm protection’ hypothesis suggests that the immunosuppressive action of androgens has evolved to protect haploid spermatozoa, which are antigenic, from autoimmune attacks. Therefore, a male with high sexual ornamentation may be more susceptible to diseases but may possess better quality ejaculate than his less ornamented rival. We studied sexual ornamentation (breeding tubercles), eja…
No uniform associations between parasite prevalence and environmental nutrients
2014
The resource quality of the host has been shown to affect parasite transmission success, prevalence, and virulence. Seasonal availability of environmental nutrients alters density and stoichiometric quality (carbon–nutrient ratios) of both producers and consumers, suggesting that nutrient availability may drive fluctuations in parasite prevalence patterns observed in nature. We examined the interactions between the population dynamics of a keystone herbivore, Daphnia, and its parasites, and their associations with water nutrient concentrations, resource quantity and quality, and other environmental variables (temperature, pH, oxygen concentration) in a small lake, using general linear model…
Alueellisen elinikäisen ohjauksen kehittäminen : viestintä ja jatkuva oppiminen
2018
Raportissa jatketaan aiemmin aloitettua elinikäisen ohjauksen alueel- lisen koordinaation tarkastelua. Empiirinen aineisto koostuu kyselyai- neistosta, johon ovat vastanneet alueelliset ryhmät. Aineiston perus- teella ELO-ryhmien toiminta näyttää kokonaisuutena vakiintuneen alueilla ja ryhmien edustajat ovat sitoutuneita alueellisen toiminnan kehittämiseen. Keskeisenä haasteena on ELO-ryhmien erilaiset toi- mintaedellytykset alueilla ja ohjaushenkilöstön täydennyskoulutuksen kansallinen koordinaatio. Haasteena on alueellisen ohjauksen yhteis- työn koordinaatio tulevan maakuntauudistuksen edetessä, ja osa ryhmistä on jo integroinut ohjauksen yhteistyön kehittämisen valmis- teilla oleviin hal…
The optimal musical pause : the effects of expectancies, musical training, and personality
2016
The musical pause is an acoustic space between musical phrases, and is an important auditory quality because it can enhance tension by delaying the expected. It has been proposed that expectancies develop from long-term schematic knowledge learned through exposure; however, the dynamic attending theory indicates that expectancies arise from localized short-term knowledge found in the stimulus. This study aims to measure the optimal duration of the pause by assessing the influence of low-level musical features, long-term familiarity, musical ability, and personality. Musical excerpts were chosen from a variety of genres to include two phrases (separable by a silence), from which participants…
Changes in Family Income around the Time of Birth of Children in Germany between 1985 and 2004
2010
Während der Verlauf und die Ursachen des Geburtenverhaltens intensiv erforscht wurden, sind die finanziellen Folgen einer Geburt empirisch kaum beachtet worden. Daher werden hier kurzfristige Wohlstandsveränderungen von Familien (hinsichtlich verfügbarem Haushaltseinkommen und Äquivalenzeinkommen) rund um die Geburt eines Kindes in längsschnittlicher Perspektive analysiert und auf ihre Ursachen untersucht. Zu diesem Zweck wurden die Daten des Sozio-oekonomischen Panels (1984-2005) mittels Fixed-Effekt-Panelregressionsmodellen analysiert. Als Ergebnis kann festgehalten werden, dass die finanziellen Folgen einer Geburt in den letzten Jahren deutlich gewachsen sind und vor allem das erste Kind…
Neljäkymmentä plus : erään ikäluokan selviytymistarina
2003
Un estudio piloto sobre el efecto diferencial de la fatiga por conducción en personas mayores
2011
Hay indicios de que la fatiga, uno de los principales efectos de la conducción prolongada, es más notable en mayores. El presente artículo recoge un estudio sobre el efecto de la conducción prolongada utilizando un simulador, en un grupo de sujetos mayores de 55 años. Los sujetos fueron evaluados médica y psicológicamente antes y después de la prueba de conducción. Se aplicaron las pruebas médicas de tensión arterial, pulso y saturación de oxígeno en sangre y como prueba psicológica, el Driver-Test. Resultados preliminares indican que existe una disminución del rendimiento después de conducir, afectando especialmente a la capacidad de toma de decisiones. Some evidences show that fatigue, th…
Tail Removal Block Validation: Implementation and Analysis
2018
In this paper a solution for the removal of long tail blocktimes in a proof-of-work blockchain is proposed, implemented and analysed. Results from the mainnet of the Bismuth blockchain demonstrate that the variances in the key variables, difficulty level and blocktime, were approximately halved after the tail removal code was enabled. Low variances in difficulty and blocktimes are desirable for timely execution of transactions in the network as well as reduction of unwanted oscillations in the feedback control problem.