Search results for "LPI"

Alteraciones del ritmo del sueño en modelos animales de encefalopatia hepática

2016

Introducción: La encefalopatía hepática (EH) es un síndrome neuropsiquiátrico presente en pacientes con enfermedades hepáticas que conduce a diferentes alteraciones neurológicas que pueden llevar al coma y la muerte. Dentro de las manifestaciones neurológicas precoces de la enfermedad, están las alteraciones del sueño con una prevalencia casi del 50% en pacientes con cirrosis hepática sin evidencia clínica. En la actualidad, varios grupos de investigación han demostrado que el deterioro cognitivo y motor de los pacientes con enfermedades hepáticas se reproduce en modelos animales con EH e hiperamonémia sin fallo hepático, así que del mismo modo, estos deben reproducir las alteraciones del s…

GABAA-receptor Subtypes: Clinical Efficacy and Selectivity of Benzodiazepine Site Ligands

1997

The main inhibitory neurotransmitter receptor of the brain, the gamma-aminobutyric acid type A receptor (GABA[A]), mediates the actions of several classes of clinically important drugs, such as benzodiazepines, barbiturates and general anaesthetics. This review summarizes the current knowledge on how classical benzodiazepines and novel nonbenzodiazepine compounds act on the benzodiazepine site of GABA(A) receptors and on their clinical pharmacology related to anxiolytic, sedative, hypnotic and cognitive effects or side-effects. Partial agonism, receptor subtype selectivity and novel binding sites are discussed as possible strategies to develop new drugs with fewer adverse effects than are s…

Zaleplon displays a selectivity to recombinant GABAA receptors different from zolipdem, zopiclone and benzodiazepines

1999

A chemically heterogeneous group of compounds acts at the benzodiazepine (BZ) recognition site of the γ-aminobutyric acid type A (GABAA) receptor complex. Whereas most 1,4-BZs recognize all GABAA/BZ receptors with similar affinity, other compounds differentiate between the large number of native GABAA receptors which assemble from the more than 14 known subunits. Here we describe the in vitro binding properties of the BZs lorazepam and Ro 15-4513 plus the three hypnotics zaleplon, zolpidem and zopiclone to eight receptors subtypes. Lorazepam fits well into the general shceme for other 1,4-BZs with respect to its receptor subtype selectivity in spite of its clinically different use. Zaleplon…

Evaluation of cropping systems for management of herbicide-resistant populations of blackgrass (Alopecurus myosuroides Huds.)

2001

Abstract Simplification of cropping systems often leads to an increase in weed populations which require an intensive use of herbicides to maintain populations at an acceptable level. Due to a heavy reliance on herbicides and a lack of cultural control measures, herbicide-resistant blackgrass (Alopecurus myosuroides Huds.) biotypes appeared recently in France. An experiment was conducted to evaluate the effects of different cropping systems on a population of herbicide-resistant blackgrass. Two crop rotations, one consisting exclusively of winter crops and another including spring crops, were assessed over a three-year period. Crop rotation was combined with different cultural practices (mo…

Et si une impasse de désherbage en agriculture de conservation des sols vous poussait à retravailler le sol ? Quelle intervention choisiriez-vous ?

2019

National audience; En Agriculture de Conservation des Sols (ACS), la perturbation minimale du sol est l’un des trois prin-cipes. Si l’impasse se fait sentir mieux vaut repenser le système que de laisser le mur se rapprocher à grands pas. Trois types de gestion d’interculture (Labour, travail superficiel (TCS) et semis direct avec glyphosate (SD)) ont été comparés sur des parcelles conduites sans labour depuis 17 ans dont les 7 dernières années en ACS sur le domaine de l’INRA de Dijon avant implantation d’un blé, sur un dispo-sitif en bandes répétées sur quatre parcelles. Des relevés de flore adventice, rendement et compo-sante de rendement ont été faite. Les densités moyennes sont faibles p…

Effect of environmental conditions on Alopecurus myosuroides germination - I : Effect of temperature and light

2002

International audience

Abundance of NARG, NIRK and NOSZ genes of denirifying bacteria during primary successions of a glacier foreland

2007

Assessing non-chemical weeding strategies through mechanistic modelling of blackgrass (Alopecurus myosuroides Huds.) dynamics

2010

 ; Because of environmental and health safety issues, it is necessary to develop strategies that do not rely on herbicides to manage weeds. Introducing temporary grassland into annual crop rotations and mechanical weeding are the two main features that are frequently used in integrated and organic cropping systems for this purpose. To evaluate the contribution of these two factors in interaction with other cropping system components and environmental conditions, the present study updated an existing biophysical model (i.e. AlomySys) that quantifies the effects of cropping system on weed dynamics. Based on previous experiments, new sub-models were built to describe the effects on plant survi…

Developmental pattern of leaves and tillers in a black grass population (Alopecurus myosuroides Huds.)

2000

International audience

Effect of intra-specific competition on development and growth of Alopecurus myosuroides Hudson

2005

International audience